冯辉

 教授，Joseph S. Pagano Award获得者

 Email：huifeng2022@cqu.edu.cn。

学习经历

2008/09-2011/07 中国科学院武汉病毒研究所  博士

2004/09-2007/06 华中农业大学              硕士

2000/09-2004/06 河北农业大学              学士

科研经历

2022/05-至今 重庆大学医学院，教授

2020/04-2022/03 河北省沧州中西医结合医院，实验室主任

2014/10-2019/09 美国北卡罗来纳大学教堂山分校，博士后

2011/08-2014/09 中国科学院水生生物研究所，博士后

研究方向、教学课程

研究方向：

病毒致病及逃逸机理

研究生教学：主讲博士研究生课程《论文写作与科研绘图》、《科研伦理与学术诚信》；参与硕士研究生课程《分子生物学技术》、《分子与细胞》、《发育与遗传》、《疾病与防治》、《医学前沿进展》理论与实践教学。

成果（1.文章2.项目3.获奖）

文章

1. Zhao J-Y, Yuan X-K, Luo R-Z, Wang L-X, Gu W, Yamane D^*, Feng H^*. Phospholipase A and acyltransferase 4/retinoic acid receptor responder 3 at the intersection of tumor suppression and pathogen restriction. Frontiers in Immunology. 2023, 14:1107239.

Sun L^#, Feng H^#, Misumi I, Shirasaki T, Hensley L, González-López O, Chou WC, Ting JP, Cullen JM, Cowley DO, Whitmire JK, Lemon SM^*. Viral protease cleavage of MAVS in genetically-modified mice with hepatitis A virus infection. Journal of Hepatology. 2023, 78(2):271-280.

2. Shirasaki T^#, Feng H^#, Duyvesteyn HME, Fusco WG, McKnight KL, Xie L, Boyce M, Kumar S, Barouch-Bentov R, González-López O, McNamara R, Wang L, Hertel-Wulff A, Chen X, Einav S, Duncan JA, Kapustina M, Fry EE, Stuart DI, Lemon SM. Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX. PLoS Pathogens. 2022, 18(8):e1010543.

3. Feng H, Zhang YB, Gui JF, Lemon SM^*, Yamane D^*. Interferon regulatory factor 1 (IRF1) and antipathogen innate immune responses. PLoS Pathogens. 2021, 17(1):e1009220.

4. Feng H, Sander AL, Moreira-Soto A, Yamane D, Lemon SM^*. Hepatovirus 3ABC proteases and evolution of mitochondrial antiviral signaling protein (MAVS). Journal of Hepatology. 2019. 71(1):25-34.

5. Yamane D^*, Feng H, Rivera-Serrano EE, Selitsky SR, Hirai-Yuki A, Das A, McKnight KL, Misumi I, Hensley L, Lovell W, González-López O, Suzuki R, Matsuda M, Nakanishi H, Ohto-Nakanishi T, Hishiki T, Wauthier E, Oikawa T, Morita K, Reid LM, Sethupathy P, Kohara M, Whitmire JK, Lemon SM^*. Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses. Nature Microbiology. 2019, 4(7):1096-1104.

6. Feng H, Lenarcic EM, Yamane D, Wauthier E, Mo J, Guo H, McGivern DR, González-López O, Misumi I, Reid LM, Whitmire JK, Ting JP, Duncan JA, Moorman NJ, Lemon SM^*. NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR. Nature Immunology. 2017, 18(12):1299-1309.

7. Feng H^#, Zhang QM^#, Zhang YB^*, Li Z, Zhang J, Xiong YW, Wu M, Gui JF. Zebrafish IRF1, IRF3 and IRF7 differentially regulate IFNΦ1 and IFNΦ3 expression through assembly of homo- or heteroprotein complexes. Journal of Immunology. 2016, 197(5):1893-904.

8. Hirai-Yuki A, Hensley L, McGivern DR, González-López O, Das A, Feng H, Sun L, Wilson JE, Hu F, Feng Z, Lovell W, Misumi I, Ting JP, Montgomery S, Cullen J, Whitmire JK, Lemon SM^*. MAVS-dependent host species range and pathogenicity of human hepatitis A virus. Science. 2016, 353(6307):1541-1545.

9. Guo H^#, König R^#, Deng M, Riess M, Mo J, Zhang L, Petrucelli A, Yoh SM, Barefoot B, Samo M, Sempowski GD, Zhang A, Colberg-Poley AM, Feng H, Lemon SM, Liu Y, Zhang Y, Wen H, Zhang Z, Damania B, Tsao LC, Wang Q, Su L, Duncan JA, Chanda SK^*, Ting JP^*. NLRX1 sequesters STING to negatively regulate the interferon response, thereby facilitating the replication of HIV-1 and DNA viruses. Cell Host & Microbe. 2016, 19(4):515-528.

10. Feng H, Zhang YB^*, Zhang QM, Li Z, Zhang QY, Gui JF^*. Zebrafish IRF1 regulates IFN antiviral response through binding to IFNϕ1 and IFNϕ3 promoters downstream of MyD88 signaling. Journal of Immunology. 2015, 194(3):1225-38.

11. Drexler JF^*, Corman VM, Lukashev AN, van den Brand JM, Gmyl AP, Brünink S, Rasche A, Seggewiβ N, Feng H, Leijten LM, Vallo P, Kuiken T, Dotzauer A, Ulrich RG, Lemon SM, Drosten C; Hepatovirus Ecology Consortium. Evolutionary origins of hepatitis A virus in small mammals. Proc Natl Acad Sci U S A. 2015, 112(49):15190-5.

12. Guo M, Feng H, Zhang J, Wang W, Wang Y, Li Y, Gao C, Chen H, Feng Y, He ZG^*. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Research. 2009, 19(7):1301-8.

承担课题

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科研奖励

2017年度  Joseph S. Pagano Award

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