一．文章
1.Shikuan Zhang, Songmao Wang, Fang Lu, Lingzi Bie, Yongjiang Luo, Jiahe Sun, Yang Zhang, Yi Wang, Yaou Zhang#,Qing Rex Lyu#. (2024) LncRNAway: a web-based sgRNA design tool for precise and effective suppression of long noncoding RNA.Nucleic Acids Research, gkae383
2.Qing Rex Lyu#, Kailong Fu#. (2023) Tissue-specific Cre driver mice to study vascular diseases.Vascular Pharmacology,153,107241
3.Lova Kajuluri*,Qing Rex Lyu*, Ajay Kumar, Samantha Sgrizzi, Joseph Miano#, Kathleen Morgan#. (2023) Calponin 1 inhibits agonist-induced ERK activation and decreases calcium sensitization in vascular smooth muscle.Journal of Cellular and Molecular Medicine28(1):e18025
4.Qing Rex Lyu#, Shikuan Zhang, Zhe Zhang, Zhiyu Tang. (2023) Functional knockout of long noncoding RNAs with genome editing.Frontiers in Genetics, 14: 1242129
5.Shikuan Zhang*, Yue Chen*, Kunzhe Dong*, Yiwan Zhao, Yanzhi Wang, Songmao Wang, Naihan Xu, Weidong Xie, Chunyu Zeng#,Qing Rex Lyu#, Yaou Zhang#. (2023) BESST: a novel gene knockout method with minimum neighborhood perturbance.Nucleic Acids Research,gkad197
6.Xavier Rambout#, Hana Cho, Romeo Blanc,Qing Lyu, Joesph M. Miano, Joe V. Chakkalakal, Geoffrey M. Nelson, Hari K. Yalamanchili, Karen Adelman, Lynne E. Maquat#. (2023) PGC-1a senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII.Molecular Cell83(2):186-202.e11
7.Ganesh D. Warthi, Jessica L. Faulkner, Jaser Doja, Amr R. Ghanam, Pan Gao, Allison C. Yang, Orazio J. Slivano, Candee T. Barris, Taylor C. Kress, Scott D. Zawieja, Susan H. Griffin, Xiaoling Xie, Alan Ashworth, Christine K. Christie, William B. Bryant, Ajay Kumar, Michael J. Davis, Xiaochun Long, Lin Gan, Eric J. Chantemèle,Qing Rex Lyu#, Joseph M. Miano#. (2022)Generation and comparative analysis of an Itga8-CreERT2 mouse with preferential activity in vascular smooth muscle cells.NatureCardiovascular Research1(11):1084-1100
8.Junyi Yu*, Wei Wang*, Jining Yang*, Ye Zhang*, Xue Gong, Hao Luo, Nian Cao, Zaicheng Xu, Miao Tian, Peili Yang, Qiao Mei, Zhi Chen, Zhuxin Li, Chuanwei Li, Xudong Duan,Qing Rex Lyu, Chen Gao, Bing Zhang, Yibin Wang#, Gengze Wu#, Chunyu Zeng#. (2022) LncRNA PSR regulates vascular remodeling through encoding a novel protein Arteridin.Circulation Research131(9):768-787
9.Suowen Xu*#,Qing Rex Lyu*, Iqra Ilyas, Xiaoyu Tian, Jianping Weng#. (2022) Vascular homeostasis in atherosclerosis: a holistic overview.Frontiers in Immunology13:976722
10.Shuang Qu, Qiao Liao, Cheng Yu, Yue Chen, Han Luo, Xuewei Xia, Duofen He, Zaicheng Xu, Pedro A Jose, Zhuxin Li, Wei Eric Wang,Qing Rex Lyu#, Chunyu Zeng#. (2022) LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis.Bosnian Journal of Basic Medical Sciences22(5):772-783
11.Qing Lyu#, Peng Yao, Joseph M. Miano. (2021)Generating a CRISPR Knock-out Mouse through a Strong Premature Termination Codon: A Cautionary Tale.Journal of Biomedical Research35(2):174
12.Qing Rex Lyu*#, Nunu Huang*, Kunzhe Dong*, Weidong Xie, Jie He, Naihan Xu, Yaou Zhang#.(2021)The miR-378/PGC1b/mTOR axis as an alternative mechanism to promote autophagy during adipogenesis.Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids1866(6):158921
13.Pan Gao*,Qing Lyu*, Amr R Ghanam, Cicera R Lazzarotto, Gregory A Newby, Wei Zhang, Mihyun Choi, Orazio J Slivano, Kevin Holden, John A Walker, Anastasia P Kadina, Rob J Munroe, Christian M Abratte, John C Schimenti, David R Liu, Shengdar Q Tsai, Xiaochun Long, Joseph M Miano.(2021)Prime editing in mice reveals the essentiality of a single base in driving cell-specific gene expression.Genome Biology22(1):83
14.Manabu Nagao,Qing Lyu, Quanyi Zhao, Robert C Wirka, Joetsaroop Bagga, Trieu Nguyen, Paul Cheng, Juyong Brian Kim, Milos Pjanic, Joseph M Miano, Thomas Quertermous. (2020)Coronary disease-associated gene TCF21 inhibits smooth muscle cell differentiation by blocking the Myocardin-serum response factor pathway.Circulation Research126(4): 517
15.Joseph Miano, Xiaochun Long, Qing Lyu. (2019) CRISPR links to long noncoding RNA function in mice: A practical approach. Vascular Pharmacology 114:1
16.Qing Lyu*#, Suowen Xu*, Yuyan Lyu, Mihyun Choi, Christine K Christie, Orazio J Slivano, Arshad Rahman, Zheng-Gen Jin, Xiaochun Long, Yawei Xu, Joseph M Miano#.(2019)SENCR regulates vascular endothelial cells adherens junction through interacting with cytoskeletal-associated protein 4.Proceedings of the National Academy of Sciences116(2):546
17.Qing Lyu, Vidhi Dhagia, Yu Han, Bing Guo, Mary E Wines-Samuelson, Christine K Christie, Qiangzong Yin, Orazio J Slivano, Paul Herring, Xiaochun Long, Sachin A Gupte, Joseph M Miano#. (2018)CRISPR-Cas9 mediated epitope tagging provides accurate and versatile assessment of Myocardin.Arteriosclerosis, Thrombosis and Vascular Biology38(9): 2184-2190
18.Bing Guo,Qing Lyu, Orazio J Slivano, Ronald Dirkx, Christine K Christie, Jan Czyzyk, Aram F Hezel, Ali G Gharavi, Eric M Small, Joseph M Miano#. (2018)Serum response factor is essential for maintenance of podocyte structure and function.Journal of the American Society of Nephrology29(2):416-422
https://doi.org/10.1681/ASN.2017050473
19.Danny Halim, Michael P Wilson, Daniel Oliver, Erwin Brosens, Joke BGM Verheij, Yu Han, Vivek Nanda,Qing Lyu, Michael Doukas, Hans Stoop, Rutger WW Brouwer, Wilfred FJ Van Ijcken, Orazio J Slivano, Alan J Burns, Christine K Christie, Karen L de Mesy Bentley, Alice S Brooks, Dick Tibboel, Suowen Xu, Zheng Gen Jin, Tono Djuwantono, Wei Yan, Maria M Alves, Robert MW Hofstra, Joseph M Miano#.(2017) Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in human and mice.Proceedings of the National Academy of Sciences114(13): E2739-E2747
20.Qing Lyu, Fangfang Tou, Hong Su, Xiaoyong Wu, Xinyi Chen, Zhi Zheng. (2015) The natural product peiminine represses colorectal carcinoma tumor growth by inducing autophagic cell death.Biochemical and Biophysical Research Communications462(1): 38-45
21.Nunu Huang, Jiangbin Wu, Wei Qiu,Qing Lyu, JIe He, Naihan Xu, Yaou Zhang. (2015)MiR-15aandmiR-16induce autophagy and enhance chemosensitivity of Campotothecin.Cancer Biology & Therapy16(6): 941-948
22.Nunu Huang, Jiu Wang, Weidong Xie,Qing Lyu, Jiangbin Wu, Jie He, Wei Qiu, Naihan Xu, Yaou Zhang(2015)MiR-378a-3penhances adipogenesis by targeting mitogen-activated protein kinase 1.Biochemical and Biophysical Research Communications457(1): 37-42
23.Kai Cui*,Qing Lyu*, Naihan Xu, Qing Liu, Jiarong Zhang, Wei Xing, Linfu Bai, Meijian Liao, Jie He, Bo Yuan, Deheng Chen, Weidong Xie, Yaou Zhang(2014) Characterization of the microRNA pool and the factors affecting its regulatory potential.Integrative Biology6(12): 1141-1152
24.Jiangbin Wu*,Qing Lv*, Jie He, Haoxiang Zhang, Xueshuang Mei, Kai Cui, Nunu Huang, Weidong Xie, Naihan Xu, Yaou Zhang(2014)MicroRNA-188suppresses G1/S transition by targeting multiple cyclin/CDK complexes.Cell Communication and Signaling12(1): 1
25.Fengqiong Liu,Qing Lv, William W Du, Haoran Li, Xiangling Yang, Danyang Liu, Zhaoqun Deng, Wenhua Ling, Yaou Zhang, Burton B Yang(2013) Specificity ofmiR-378a-5ptargeting rodent fibronectin.BBA-Molecular Cell Research1833(12): 3272-3285
26.Can Yi, Wei-dong Xie, Fu Li,Qing Lv, Jie He, Jiangbin Wu, Dayong Gu, Naihan Xu, Yaou Zhang(2011)MiR-143enhances adipogenic differentiation of 3T3-L1 cells through targeting the coding region of mouse pleiotrophin.FEBS Letters585(20): 3303-3309
27.Jin-fang Zhang, Wei-ming Fu, Ming-liang He, Wei-dong Xie,Qing Lv, Gang Wan, Guo Li, Hua Wang, Gang Lu, Xiang Hu, Su Jiang, Jian-na Li, Marie CM Lin, Ya-ou Zhang, HsiangFu Kung(2011) MiRNA-20a promotes osteogenic differentiation of human mesenchymal stem cells by co-regulating BMP signaling.RNA Biology8(5): 829-838
28.Jie He, Jin-fang Zhang, Can Yi,Qing Lv, Wei-dong Xie, Jian-na Li, Gang Wan, Kai Cui, Hsiang-fu Kung, Jennifer Yang, Burton B. Yang, Yaou Zhang. (2010) MiRNA-mediated functional changes through co-regulating function related genes.PLoS One5(10): e13558
29.Wenbin Ye*,Qing Lv*, Chung-Kwun Amy Wong, Sean Hu, Chao Fu, Zhong Hua, Guoping Cai, Guoxi Li, Burton B. Yang, Yaou Zhang. (2008) The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation.PLoS One3(3): e1719
30.Dayong Gu, Bing Yu, Chen Zhao, Wenbin Ye,Qing Lv, Zhong Hua, Jiangan Ma, Yaou Zhang. (2007) The effect of pleiotrophin signaling on adiopogenesis.FEBS Letters581(3): 382-388
31.Zhong Hua*,Qing Lv*, Wenbin Ye*, Chung-Kwun Amy Wong, Guoping Cai, Dayong Gu, Yanhong Ji, Chen Zhao, Jifeng Wang, Burton B. Yang, Yaou Zhang. (2006) MiRNA-directed regulation ofVEGFand other angiogenic factors under hypoxia.PLoS One1(1): e116
二．承担和参与的科学研究项目
[1]国家自然科学基金面上项目，血管平滑肌异质性在胸主动脉瘤和夹层形成中的作用及机制研究（82570558）；项目负责人（2026.1-2029.12）
[2]国家自然科学基金面上项目，聚苯乙烯微塑料促进空肠脂质吸收导致肥胖的作用及机制研究（82270908）；项目负责人（2023.1-2026.12）
[3]国家自然科学基金面上项目，CKAP4促进TGF-beta1蛋白合成并抑制腹主动脉瘤形成的作用及机制研究（82070486）；项目负责人（2021.1-2024.12）
[4]美国心脏协会博士后Fellowship, U.S. (PI) (2017): #17POST33660938，项目负责人
