庄娜

学历:博士

职称:副研究员

研究方向:肿瘤免疫耐药

学术任职

 重庆市医学青年拔尖人才

学习经历

1. 2013.09-2018.10清华大学生命科学学院生物学专业博士

2. 2009.09-2013.07华中农业大学生命科学技术学院生物科学专业学士

工作经历

2024.1-至今 重庆大学附属肿瘤医院 副研究员

2023.4-2023.12 重庆大学附属肿瘤医院 助理研究员

2019.7-2023.3 重庆大学附属肿瘤医院 在站博士后

2018.11-2019.4 上海艾瑞德生物科技有限公司 研发工程师

研究方向、教学课程

1.肝癌发生与进展

2.肿瘤免疫治疗与耐药机制研究

成果

一、文章

1.Junyu Xiang, Yuanli Ni, Jiajun Yu, Hui Sun, Zhiyun Gu, Ziyong Li, Tongwang Yang, Juan Feng, Li Su, Limei Liu, Jiatao Li, Jesus Prieto, Matías A. Ávila,  Juanjuan Shan, Na Zhuang & Cheng Qian. MEF2D-expressing cancer precursors reprogram tissue-resident macrophages to support liver tumorigenesis. Nature Cancer 2025,6(12):1955-1975 doi: 10.1038/s43018-025-01059-1. ( Corresponding author)

2.Zhiyun Gu#, Tongwang Yang#, Yuanli Ni, Yuanze Zhou*, Cheng Qian* and Na Zhuang*. PINK1 dysfunction in hepatocellular carcinoma fosters immune evasion and disease progression by promoting neutrophil infiltration. Journal for ImmunoTherapy of Cancer 2025,13(12):e013079 doi: 10.1136/jitc-2025-013079. (Corresponding author)

3.Tongwang Yang*, Zhiyun Gu*, Juan Feng, Juanjuan Shan, Cheng Qian and Na Zhuang. Non-parenchymal cells: key targets for modulating chronic liver diseases. Frontiers in Immunology 2025, 16:1576739 doi: 10.3389/fimmu.2025.1576739.  (Corresponding author)

4. Juan Feng*, Yongliang Liu*, Na Zhuang*, Zixuan Chai, Limei Liu, Cheng Qian, Jiatao Li, Juanjuan Shan. EDA-E7 Activated DCs Induces Cytotoxic T Lymphocyte Immune Responses against HPV Expressing Cervical Cancer in Human Setting. Vaccines 2023,11(2):320, doi: 10.3390/vaccines11020320. ( *co-first author)

5.Na Zhuang*, Zhiyun Gu*, Juan Feng*, Zixuan Chai, Juanjuan Shan, Cheng Qian. BEX1 mediates sorafenib resistance in hepatocellular carcinoma by regulating AKT signaling. Cellular Signalling 2023,108:110722, doi: 10.1016/j.cellsig.2023.110722.(First author)

6.冯娟,李佳涛,庄娜CRISPR/Cas9 敲除内源 TCR 增强 TCR-T 细胞对 HPV16 阳性宫颈癌SiHa细胞的杀伤。中国肿瘤生物治疗杂志 2023, 30(5): 373-379.(通讯作者)

7.Han Yongchao, Zhuang Na, Wang Tao. Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila.Cell reports 2021,34(12):108875 doi: 10.1016/j.celrep.2021.108875.

8.Zhuang N, Li L, Chen S, Wang T. PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control. Cell death &disease 2016, 7(12):e2501doi: 10.1038/cddis.2016.396. (First author)

9.Wu K*, Liu J*, Zhuang N*, Wang T. UCP4A protects against mitochondrial dysfunction and degeneration in  pink1/parkin models  of  Parkinson's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014,28(12):5111-21, doi: 10.1096/fj.14-255802. (*co-first author)

二、承担和参与的科学研究项目

[1].国家自然科学基金青年项目,PINK1通过调控肿瘤内中性粒细胞促进肝癌对PD-L1抗体治疗耐受的分子机制研究82101931; 项目负责人2022.1-2024.12

[2].重庆市自然科学基金面上项目,PINK1通过改变肿瘤免疫微环境调控HCC对PD-L1抗体响应的分子机制研究CSTB2024NSCQ-MSX0416);项目负责人(2024.7-2027.6

[3].重庆市自然科学基金博士后科学基金项目,BEX1失调促进HCC耐受Sorafenib治疗的机制研究cstc2020jcyj-bshX0009项目负责人(2020.9-2022.8

[4].重庆市医学科研青年拔尖人才项目YXQN2025020项目负责人(2025.8-2028.7

[5].重庆市科卫联合项目面上项目,靶向降解MLL-AF9纳米抗体的筛选优化及其在白血病治疗中的应用研究2026MSXM035);项目负责人(2026.1-2027.12

三、相关奖励与荣誉

[1] 2025年重庆市医学青年拔尖人才

[2] 2023年重庆市科协岗位创新争先行动一等奖