孔光耀

学术兼职

中国生理学会血液生理专业委员会委员

中国病理生理学会实验血液学专业委员会委员

中国医药质量管理协会细胞治疗质量控制与研究专业委员会委员

中国医药生物技术协会科研实验室建设与管理分会常委

重庆市医学会血液学分会委员

重庆市医师学会血液科医师分会委员


学习经历

2000-2007  陕西师范大学    本硕

2008-2011  南开大学      博士


工作经历


2011-2016  美国威斯康星大学麦迪逊分校  博士后

2017-2026  西安交通大学第二附属医院    教授

2024.7-至今  重庆大学附属涪陵医院     教授


研究方向

骨髓血液肿瘤精准治疗、肿瘤分子生物学


学术论文

   1. hang P, Feng K, Yu X, Yang Y, Luo S, Li Q, Zhang H, Jia Y, Fei Q, Ren X, Liu H, Li L, Yang D, Munyurangabo G, Yue J, Li Q, Zhang P, Song L, He A, Lu Z#, Zhang L#, Kong G#. The m6A methyltransferase METTL14 promotes oncogenic Kras induced juvenile myelomonocytic leukemia through dysregulating autophagy.Cell Death Differ. 2025 Aug 16. (#corresponding author)

2. Munyurangabo G, Zhang L, Zhou Y, Zhang P, Yu X, Qu D, Yang D, Ren X, Liu H, Wu Y, Kong G, Yang Y. Co-operative epigenetic remodelling by Setd2 deficiency and Kras mutation drives juvenile myelomonocytic leukaemia development and MEK inhibitor sensitivity. Br J Haematol. 2025 Oct;207(4):1289-1300. (#corresponding author)

3. Zhang L#, Yang Y, Yu X, Li G, Zhang P, Ren X, Luo S, Li L, Munyurangabo G, Jia Y, Song L, He A, Kong G#. Arachidonic acid promotes myeloid differentiation of splenic CD45- Ter119+ cells in myeloproliferative neoplasm. J Cancer. 2025 Mar 31;16(7):2289-2297. (#corresponding author)

4. Zhang Z, Lin X, Yang Y, Wang X, Wang Y, Huang X, Hong M, Gao W, He H, You MJ, Yang Y#, Kong G#. Caspase 3-specific cleavage of ubiquitin-specific peptidase 48 enhances drug-induced apoptosis in AML. Cancer Biol Ther. 2025 Dec;26(1):2459426. (#corresponding author)

5. Yang Y, Zhang L, Munyurangabo G, Zhou Y, He S, Zhang P, Yu X, Kong G#. Deficiency of the histone H3K36 methyltransferase SETD2 inhibits the proliferation and migration of hepatocellular carcinoma cells.J Cancer. 2024 Oct 21;15(20):6479-6489. (#corresponding author)

6. Zhong F, Zhang X, Wang Z, Li X, Huang B, Kong G#, Wang X#.The therapeutic and biomarker significance of ferroptosis in chronic myeloid leukemia. Front Immunol. 2024 Jul 4; 15:1402669. (#corresponding author)

7. Yin M, Liu L, Yan Y, Wang H, Li W, Dong Y, Kong G#. A targeting nanoplatform for chemo-photothermal synergistic therapy of small-cell lung cancer. Int J Cancer. 2024 Dec 1;155(11):2094-2106. (#corresponding author)

8. Liu J, Li L, He S, Zheng X, Zhu D, Kong G#, Li P#. Exploring the prognostic necroptosis-related genes and underlying mechanism in sepsis using bioinformatics. Shock. 2024 Sep 1;62(3):363-374. (#corresponding author)

9. Zhong F, He S, Guo N, Shi L, Zhang L, Jin H, Kong G#. A novel immunogenic cell death-related classification indicates the immune landscape and predicts clinical outcome and treatment response in acute myeloid leukemiaCancer Cell Int. 2024 Apr 16. 24(1):139(#corresponding author)

10. Jia Y, Liu R, Shi L, Feng Y, Zhang L, Guo N, He A, Kong G#. Integrative analysis of the prognostic value and immune microenvironment of mitophagy-related signature for multiple myeloma. BMC Cancer. 2023 Sep 12;23(1):859. (#corresponding author)

11. Jia Y, Yu X, Liu R, Shi L, Jin H, Yang D, Zhang X, Shen Y, Feng Y, Zhang P, Yang Y, Zhang L, Zhang P, Li Z#, He A#, Kong G#. PRMT1 methylation of WTAP promotes multiple myeloma tumorigenesis by activating oxidative phosphorylation via m6A modification of NDUFS6. Cell Death & Disease,2023 Aug 9;14(8):512. (#corresponding author)

12. Li Z, He Z, Wang J,Kong G#. RNA splicing factors in normal hematopoiesis and hematologic malignancies: novel therapeutic targets and strategies. J Leukoc Biol, 2023 Feb 1;113(2):149-163. (#corresponding author)

13. Zhongqiang Zheng, Huan Wang, Liang Li, Shaoying Zhang, Chunyan Zhang, Hailong Zhang, Fanpu Ji, Xi Liu, Kai Zhu, Guangyao Kong#, Zongfang Li#. Splenectomy enhances the Ly6Clow phenotype in hepatic macrophages by activating the ERK1/2 pathway during liver fibrosis. Int Immunopharmacol. 2020 (#corresponding author)

14. Li J, Li R, Jiang W, Sun J, Li J, Guo Y, Zhu K, Zhang C, Kong G#, Li Z#. Splenic serum from portal hypertensive patients enhances liver stem cell proliferation and self-renewal via the IGF-II/ERK signaling pathway. Dig Liver Dis. 2020 (#corresponding author)

15. Zhang H, Zhang S, Zhang J, Zhou R, Nie Y, Ren S, Li J, Feng K, Ji F, Kong G#, Li Z#. Improvement of human platelet aggregation post-splenectomy with paraesophagogastric devascularization in chronic hepatitis B patients with cirrhotic hypersplenism. Platelets. 2019 (#corresponding author)

16. Zhu K, Li J, Li J, Sun J, Guo Y, Tian H, Li L, Zhang C, Shi M, Kong G#, Li Z#. Ring1 promotes the transformation of hepatic progenitor cells into cancer stem cells through the Wnt/β-catenin signaling pathway. J Cell Biochem. 2019 (#corresponding author)

17. Sun J, Guo Y, Bie B, Zhu M, Tian H, Tian J, Li J, Yang Y, Ji F, Kong G#, Li Z#. Silencing of long noncoding RNA HOXD-AS1 inhibits proliferation, cell cycle progression, migration and invasion of hepatocellular carcinoma cells through MEK/ERK pathway. J Cell Biochem. 2019 (#corresponding author)

18. You X, Wen Z, Chang YI, Ranheim EA, Zhou Y, Zhou L, Kong G#, Zhang J#. Systemic Notch downregulation promotes KrasG12D -induced myeloproliferative neoplasm. Br J Haematol. 2019 (#corresponding author)

19. Kong G*#, You X*, Wen Z, Chang YI, Qian S, Ranheim EA, Letson C, Zhang X, Zhou Y, Liu Y, Rajagopalan A, Zhang J, Stieglitz E, Loh M, Hofmann I, Yang D, Zhong X, Padron E, Zhou L, Pear WS, Zhang J.#. Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. Leukemia. 2019 (#corresponding author)

20. Lu Z*, Hong CC*, Kong G*, Assumpção ALFV#, Ong IM, Bresnick EH, Zhang J, Pan X. Polycomb Group Protein YY1 Is an Essential Regulator of Hematopoietic Stem Cell Quiescence. Cell Rep. 22(6):1545-1559. 2018(*equal contribution)

21. Li Y, Jiang W, Li ZZ, Zhang C, Huang C, Yang J, Kong GY#, Li ZF#. Repetitive restraint stress changes spleen immune cell subsets through glucocorticoid receptor or β-adrenergic receptor in a stage dependent manner. Biochem Biophys Res Commun. 2018 (#corresponding author)

22. Wang P, Li Z, Ren S, Li J, Yang J, Kong G#, Jiang A#, Li Z#.Spleen Regulates Hematopoietic Stem/Progenitor Cell Functions Through Regulation of EGF in Cirrhotic Hypersplenism.Dig Dis Sci.2018 (#corresponding author)

23. Jiang W, Li Y, Sun J, Li L, Li JW, Zhang C, Huang C, Yang J, Kong GY#, Li ZF#. Spleen contributes to restraint stress induced changes in blood leukocytes distribution. Sci Rep. 2017 (#corresponding author)

24. Zhang J*, Kong G*, Rajagopalan A, Lu L, Song J, Hussaini M, Zhang X, Ranheim EA, Liu Y, Wang J, Gao X, Chang YI, Johnson KD, Zhou Y, Yang D, Bhatnagar B, Lucas DM, Bresnick EH, Zhong X, Padron E, Zhang J. p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia. Blood. 2017 (*equal contribution)

25. Kong G, Chang YI, You X, Ranheim EA, Zhou Y, Burd CE, Zhang J. The ability of endogenous Nras oncogenes to initiate leukemia is codon-dependent. Leukemia. 2016

26. Kong G*, Chang Y-I*, Damnernsawad A*, You X*, Du J, Ranheim E, Lee W, Ryu M, Zhou Y, Xing Y, Chang Q, Burd C, Zhang J. Loss of wild-type Kras promotes activation of all Ras isoforms in oncogenic Kras-induced leukemogenesis. Leukemia. 2016 (*equal contribution)

27. Johnson, K. D.*, Kong, G*, Gao, X., Chang, Y-I., Hewitt, K. J., Sanalkumar, R., Sanalkumar, P., Ranheim, R. A., Dewey, C. N., Zhang, J., and Bresnick, E. H. Cis-regulatory Mechanisms Governing Stem and Progenitor Cell Transitions. Science Advances. Science Advances 2015 (*equal contribution)

28. Kong G, Wunderlich M, Yang D, Ranheim EA, Young KH, Wang J, Chang YI, Du J, Liu Y, Tey SR, Zhang X, Juckett M, Mattison R, Damnernsawad A, Zhang J, Mulloy JC, Zhang J. Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm. The Journal of Clinical Investigation. 2014

29. Wang J*, Kong G*, Liu Y, Du J, Chang YI, Tey SR, Zhang X, Ranheim EA, Saba-El-Leil MK, Meloche S, Damnernsawad A, Zhang J, Zhang J. NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions. Blood. 2013 (*equal contribution)

30. Kong G*, Du J*, Liu Y, Meline B, Chang YI, Ranheim EA, Wang J, Zhang J. Notch1 mutations target Kras G12D CD8+ cells and contribute to their leukemogenic transformation. J Biol Chem. 2013 (*equal contribution)


承担和参与的科学研究项目

82370146 在幼年型粒单核细胞白血病中鉴定CD69作为其白血病干细胞新表面标记的实验研究 国家自然科学基金面上项目 主持

82170140 基于造血干祖细胞异质性研究幼年型粒单核细胞白血病对MEK抑制剂耐药的新机制 国家自然科学基金面上项目 主持

81922003 骨髓异常增生/骨髓增殖性肿瘤  国家自然科学基金优秀青年科学基金项目主持

2019YFA0801804 跨器官通讯影响病理状态下造血稳态的作用和机理 国家重点研发计划课题 课题负责人

81770127 Runx1在慢性粒单核细胞白血病中的作用及其机制研究 国家自然科学基金面上项目 主持

81600100 Notch信号通路在幼年型粒单核细胞白血病中细胞自主性和非细胞自主性作用的研究 国家自然科学基金青年项目 主持


奖励与荣誉

国家自然科学基金委优青

重庆市医学领航人才

陕西省百人特聘专家