一、文章
1.Xiang J, Ni Y, Yu J, Sun H, Gu Z, Li Z, Yang T, Feng J, Su L,Liu L,Li J,Prieto J, Avila MA, Shan J*, Zhuang N*, Qian C*. MEF2D-expressing cancer precursors reprogram tissue-resident macrophages to support liver tumorigenesis. NATURE CANCER.DEC 2025. DOI:10.1038/s43018-025-01059-1
2.Wang MZ,Zhuang N, Feng J*, Qian C*,DLD-HLNP/P@IR780 for efficient lung-parenchyma accumulation to treat idiopathic pulmonary fibrosis. VIEW. DEC 2025. Volume6 I ssue6. DOI:10.1002/VIW.20250129
3.Zhu X,Chen J,Li W,Xu Y,Shan J,Hong J,Zhao Y,Xu H,Ma J,Shen J*,QianC*.Hypoxia-Responsive CAR-T Cells Exhibit Reduced Exhaustion and Enhanced Efficacy in Solid Tumors.CANCER RESEARCH.JAN 2024.DOI:10.1158/0008-5472.CAN-23-1038
4.Li W, Zhu X, Xu Y, Chen J, Zhang H,Yang Z, Qi Y, Hong J, Li Y,Wang G, Shen J*, Qian C*.Simultaneous editing of TCR, HLA-I/II and HLA-E resulted in enhanced universal CAR-T resistance to allo-rejection. FRONTIERS IN IMMUNOLOGY.DEC 2022.DOI:10.3389/fimmu.2022.1052717
5.Xiang J, Zhang N, Sun H, Su L, Zhang C, Xu H, Feng J, Wang M, Chen J, Liu L, Shan J, Shen J, Yang Z, Wang G, Zhou H, Prieto J, Ávila MA, Liu C, Qian C*.Disruption of SIRT7 Increases the Efficacy of Checkpoint Inhibitor via MEF2D Regulation of Programmed Cell Death 1 Ligand 1 in Hepatocellular Carcinoma Cells.Gastroenterology.2020 Feb;158(3):664-678.DOI:10.1053/j.gastro.2019.10.025
6.Heng G, Jia J, Li S, Fu G, Wang M, Qin D, Li Y, Pei L, Tian X, Zhang J, Wu Y, Xiang S, Wan J, Zhu W, Zhang P, Zhang Q, Peng X, Wang L, Wang P, Wei Z, Zhang Y, Wang G, Chen X, Zhang C, Sun Y, Zhao W, Fan Y, Yang Z, Chen J*,Qian C*.Sustained Therapeutic Efficacy of Humanized Anti-CD19 Chimeric Antigen Receptor T Cells in Relapsed/Refractory Acute Lymphoblastic Leukemia. Clin Cancer Res. 2020 Apr 1;26(7):1606-1615.DOI:10.1158/1078-0432.CCR-19-1339
7.Wei Z, Jia J, Heng G, Xu H, Shan J, Wang G, Liu C, Xia J, Zhou H, Wu M, Yang Z, Wang M, Xiong Z, Huang H, Liu L*,Qian C*.Sirtuin-1/Mitochondrial Ribosomal Protein S5 Axis Enhances the Metabolic Flexibility of Liver Cancer Stem cells. Hepatology,2019 Oct;70(4):1197-1213. DOI:10.1002/hep.30622
8.Chen X,Huan H,Liu C,Luo Y,Shen J,Zhou Y,Zhang Z*,Qian C*.Deacetylation of β-catenin by SIRT1 regulates self-renewal and oncogenesis of liver cancer stem cells.Cancer Letters.463 (2019) 1–10.DOI:10.1016/j.canlet.2019.07.021
9.Liu C, Liu L, Chen X, Cheng J, Zhang H, Shen J, Shan J, Xu Y,Yang Z,Lai M,Qian C*.Sox9 Regulates Self-Renewal and Tumorigenicity by Promoting Symmetrical Cell Division of Cancer Stem Cells in Hepatocellular Carcinoma.Hepatology.2016.DOI:10.1002/hep.28509
10.Liu L,Liu C,Zhang Q,Shen J,Zhang H,Shan J,Duan G,GuoD,Chen X,Cheng,J,Xu Y,Yang Z,Yao C, Lai M,Qian C*.SIRT1-Mediated Transcriptional Regulation of SOX2 is important for Self-Renewal of Liver Cancer Stem Cells.Hepatology, 2016.DOI:10.1002/hep.28690
二、承担和参与的科学研究项目
[1]国家自然科学基金重点国际合作项目,MEF2D介导的肝脏免疫微环境重塑在炎症诱导肝癌发生中的作用及机制研究(82120108019);项目负责人(2022.1-2026.12)
[2]国家科技部重点研发计划课题,发现肿瘤新抗原并建立数据库(2022YFC13401601);课题负责人(2022.11-2027.10)
[3]国家自然科学基金重大研究计划,肿瘤去分化与肿瘤微环境相互作用的机制和可视化研究(91959206);项目负责人(2020.1-2023.12)
[4]国家自然科学基金重点国际合作项目,MEF2D在肿瘤微环境调控肝癌侵袭转移中的作用及分子机制研究(520108025);项目负责人(2016.1-2020.12)
[5]国家科技部重点研发计划,恶性肿瘤免疫治疗关键技术研究(2016YFC1303400);项目负责人(2016.9-2020.12)
[6]重庆市社会事业与民生保障科技创新专项,疾病精准生物治疗技术研发及应用(cstc2016shms-ztzx10006);项目负责人(2016.10-2019.10)
[7]国家自然科学基金重点项目,SIRT1在调控肝癌干细胞自我更新中的作用及分子机制(81330048);项目负责人(2014.1-2018.12)
[8]国家自然科学基金重大项目,结直肠癌EMT模型的建立与转移干预的研究(8190423);项目负责人(2011.1-2014.12)
[9]国家自然科学基金重点国际合作项目,CIK细胞介导溶瘤腺病毒靶向治疗肝癌的实验研究(81020108026),项目负责人(2011.1-2013.12)
三、相关奖励与荣誉
[1] 爱思唯尔2021-2024年度“中国高被引学者”
[2] 2019年获重庆市首届创新争先奖先进个人