主持国家自然科学基金青年项目、中国博士后面上项目、重庆市博士后研究项目特别资助、重庆市自然科学基金面上项目、重庆市医学青年拔尖人才项目、教育部重点实验室研究项目、重庆市研究生科研创新项目等多项国家/省部级科研项目。以第一和通讯作者发表SCI论著(Original Research Article)11篇(其中IF>15分2篇,IF>10分3篇),论文获 H1 Connect(F1000/Faculty Opinions)推荐点评。授权国家发明专利3项、实用新型专利2项,参编专著2部。入选2024年重庆市博士后创新人才支持计划。
一、以通讯(*)/第一作者( # )(含共同)发表的SCI论著
(1)Y. Yuan#, L. H. Wang, X. X. Zhao, J. Wang, M. S. Zhang, Q. H. Ma, S. Wei, Z. X. Yan, Y. Cheng, X. Q. Chen, H. B. Zou, J. Ge, Y. Wang, X. Zhang, Y. H. Cui, T. Luo and X. W. Bian. 2022. The E3 ubiquitin ligase HUWE1 acts through the N-Myc-DLL1-NOTCH1 signaling axis to suppress glioblastoma progression. Cancer Commun (Lond) 42(9). 868-886.(IF=24.9)
(2)Ye Yuan#, Xudong Liu, Liwen Kuang, Shixue Yang, Lihong Wang, Jiao Wang, Sen Wei, Zexuan Yan, Qinghua Ma, Juan Lei, Yu Zhou, Yu Chen, Jiongming Chen, Tao Luo, Kaidi Yang, Mengsi Zhang and Yongsheng Li. 2025. Endothelial cell-derived SDF-1alpha elicits stemness traits of glioblastoma via dual-regulation of GLI1. Theranostics 15(18). 9819-9837. (IF=13.3)
(3)L.H.Wang, Y.Yuan #, J.Wang, Y.Luo, Y.Lan, J.Ge, L.Li, F. Liu, Q.Deng, Z.X.Yan, M.Liang,S. Wei,X. D.Liu, Y.Wang, Y.F. Ping, Y.Shi, S.C.Yu, X.Zhang, Y.H.Cui, X.H.Yao, H.Feng, T.Luo and X.W.Bian. 2022. ASCL2 Maintains Stemness Phenotype through ATG9B and Sensitizes Gliomas to Autophagy Inhibitor. Adv Sci (Weinh) 9(27). e2105938.(IF=15.1)
(4)Li-Hong Wang, Sen Wei, Ye Yuan #, Ming-Jun Zhong, Jiao Wang, Ze-Xuan Yan, Kai Zhou, Tao Luo, Li Liang and Xiu-Wu Bian. 2024. KPT330 promotes the sensitivity of glioblastoma to olaparib by retaining SQSTM1 in the nucleus and disrupting lysosomal function. Autophagy 20(2). 295-310. (IF=14.3)
(5)Kaidi Yang, Shihui Fu, Jingbing Liang, Lijuan Ding, Junhao You, Fang Li4, Ye Yuan*, Xiu-wu Bian.2025. Unveiling a BRAF Signature Proficient in Accurately Capturing Oncogenic Activity and Guiding Prognostic Prediction across Multiple Cancers. MedComm (2020)e75209. (IF=10.7)
(6)Ye Yuan#, Zexuan Yan, Jingya Miao, Ruili Cai, Mengsi Zhang, Yanxia Wang, Lihong Wang, Weiqi Dang, Di Wang, Dongfang Xiang, Yan Wang, Peng Zhang, Youhong Cui, Xiuwu Bian and Qinghua Ma. 2019. Autofluorescence of NADH is a new biomarker for sorting and characterizing cancer stem cells in human glioma. Stem Cell Res Ther 10(1). 330. (IF=6.8)
(7)X. Zhao, Y. Yuan#, X. Liu, F. Mao, G. Xu and Q. Liu. 2022. A Versatile Platform for Sensitive and Label-Free Identification of Biomarkers through an Exo-III-Assisted Cascade Signal Amplification Strategy. Anal Chem 94(4). 2298-2304.(IF=6.7)
(8)Yue Cheng, Shijie Li, Yongying Hou, Weijun Wan, Ke Wang, Shihui Fu, Kaidi Yang, Ye Yuan* and Xiufeng Ye. 2023. Glioma-derived small extracellular vesicles induce pericyte-phenotype transition of glioma stem cells under hypoxic conditions. Cell Signal 109(110754) (IF=4.8)
(9)Y. Yuan#, M. Zhang, G. Yan, Q. Ma, Z. Yan, L. Wang, K. Yang and D. Guo. 2021. Nanog promotes stem-like traits of glioblastoma cells. Front Biosci (Landmark Ed) 26(3). 552-565. (IF=3.1)
(10)Kang Song, Ye Yuan#, Yong Lin, Yan-Xia Wang, Jie Zhou, Qu-Jing Gai, Lin Zhang, Min Mao, Xiao-Xue Yao, Yan Qin, Hui-Min Lu, Xiang Zhang, You-Hong Cui, Xiu-Wu Bian, Xia Zhang and Yan Wang. 2018. ERBB3, IGF1R, and TGFBR2 expression correlate with PDGFR expression in glioblastoma and participate in PDGFR inhibitor resistance of glioblastoma cells. Am J Cancer Res 8(5). 792-809. (IF=4.9)
(11)X.Liu, Y.Yuan#, X.Zhao, Z.Cao, M.Zhu, T.Li and Z.Wu. 2022. Accurate detection of lung cancer-related microRNA through CRISPR/Cas9-assisted garland rolling circle amplification. J Thorac Dis 14(11). 4427-4434
二、授权专利
(1)C620-0580在制备抗胶质瘤药物中的应用,授权公告日2025-08-29,中国, ZL202211719804.8
(2)SJB2-043作为抑制胶质母细胞瘤的药物的用途,授权公告日2023-09-05,中国, ZL202210088535.3
(3)一种用于检测泛癌BRAF突变活性的特征基因集及应用,授权公告日2025-09-09,中国, ZL202510877022.4
(4)一种医院试管管理用的试管架,授权公告日2018-12-28,中国, ZL 201820532168.0
(5)一种医院用医疗垃圾处理装置,授权公告日2019-01-08,中国, ZL 201820532757.9
三、 目前承担的代表性科研项目
(1)国家自然科学基金青年项目,82403754,小分子化合物SJB2-043通过下调USP32促进EGFR泛素化降解抑制胶质母细胞瘤增殖的机制研究,30万元,2025/1-2027/12,在研,项目负责人。
(2)中国博士后科学基金面上资助,2024M753867,8万元,2024/8-2026/12,在研,项目负责人。
(3)重庆市博士后创新人才支持计划,CQBX202423,60万元,2025/1-2027/12,在研,项目负责人。
(4)重庆市自然科学基金面上项目,CSTB2024NSCQ-MSX0499,去泛素化酶USP4通过稳定EGFR蛋白维持胶质瘤干细胞干性的作用及机制研究,10万元,2024/7-2027/6,在研,项目负责人。
(5)重庆市博士后研究项目特别资助,2023CQBSHTB2034,10万元,2023/9-2026/12,在研,项目负责人。
(6)重庆市医学青年拔尖人才项目,YXQN2025082,20万元,2026/1-2028/12,在研,项目负责人。
四、相关奖励与荣誉
(1)2020年度重庆市医学会病理学分会“优秀青年论文”奖
(2)2023年度陆军军医大学优秀博士论文
(3)2023年博士研究生国家奖学金
(4)2024年度重庆市优秀博士论文
(5)2024年度重庆大学附属肿瘤医院“科技创新先进个人”一等奖
(6)2024年入选重庆市“博士后创新人才支持计划”