学术兼职

重庆市医学会医学伦理分会委员，重庆市高等教育委员会医学教育专委会委员，重庆市医学会流行病学和循证医学分会青年学组副组长

学习经历

南开大学博士，美国威斯康星大学博士后

研究方向

造血干细胞发育，骨髓血液肿瘤的发病机制及精准诊疗

学术论文

[1] Zhang P, Feng K, Yu X, Yang Y, Luo S, Li Q, Zhang H, Jia Y, Fei Q, Ren X, Liu H, Li L, Yang D, Munyurangabo G, Yue J, Li Q, Zhang P, Song L, He A, Lu Z#, Zhang L#, Kong G#. The m6A methyltransferase METTL14 promotes oncogenic Kras induced juvenile myelomonocytic leukemia through dysregulating autophagy. Cell Death Differ, 2025; Aug 16.

[2] Saka S*, Lu Z*, Wang Y, Liu P, Singh DK, Lee JP, Palii CG, Alvarez TR, F V Assumpção AL, You X, Zhang J, Brand M, Atchison ML, Pan X. Chromatin factor YY1 controls fetal hematopoietic stem cell migration and engraftment in mice. J Clin Invest, 2025; Jul 29: e188140.

[3] Long Y, Zhang Q, Ling L, Zhang Y, Wei X, Huang H, Lu Z, Huang Y, Chen X, Ye Y, Feng X, Zhang H, Huang B, Huang Y, Liang Y, Fang M, Makamura Y, Lin B, Zhang X, Lu D, Jin X, Xu X. Mutations in AMBRA1 aggravate β-thalassemia by impairing autophagy-mediated clearance of free α-globin. Blood, 2025; 145(10): 1074-1088.

[4] Lu Z, Wang Y, Assumpção ALFV, Liu P, Kopp A, Saka S, Mcilwain SJ, Viny AD, Brand M, Pan X. Yin Yang 1 regulates cohesin complex protein SMC3 in mouse hematopoietic stem cells. Blood Advances, 2024; 8(12):3076-3091.

[5] Lu Z, Hong CC, Kong G, Assumpção ALFV, Ong IM, Bresnick EH, Zhang J, Pan X. Polycomb group protein YY1 is an essential regulator of hematopoietic stem cell quiescence. Cell Reports, 2018; 22: 1545-1559.

[6] Lu Z, Xiao Z, Yang Z, Li J, Feng G, Chen F, Li Y, Feng J, Gao Y, Ye L, Zhang X. Hepatitis B virus X protein modulates sphingosine kinase 1 via up-regulating transcription factor AP2α in promotion of hepatoma cell growth. Acta Pharmacologica Sinica, 2015; 36:1228-36.

[7] Lu Z, Hong CC, Jark PC, Assumpção ALFV, Bollig N, Kong G, Pan X. JAK1/2 inhibitors AZD1480 and CYT387 inhibit canine B-cell lymphoma growth by increasing apoptosis and disrupting cell proliferation. J Vet Intern Med. 2017; 31: 1804-1815.

承担和参与的科学研究项目

2020.1-2022.12       国家自然科学基金青年项目（81900194）“超保守RNA uc.131-134基因簇在B细胞淋巴瘤中的表达调控和作用机制研究”，20万，主持。

2025.1-2029.12       重庆大学附属涪陵医院科研启动金，100万，主持。

2026.1-2027.12      神经与肿瘤药物研发全国重点实验室开放课题“SETD2通过表观遗传修饰调控DUSP1/MAPK/ERK信号通路抑制幼年型粒单核细胞白血病的作用机制研究”，5万，主持。