一、主持项目
1.SIRT6调控血管平滑肌细胞AP-1及其下游基质金属蛋白酶2/9抑制高血压血管重塑的机制研究。第一负责人, 国家自然科学基金青年项目,2018.01-2020.12,81700229。
2. 柴胡皂苷D活化PI3K-Akt通路抑制阿霉素心肌损伤的分子机制研究。第一负责人,重庆市科研机构绩效激励引导专项,2020.01-2021.12,cstc2018jxjl130026。
3. 基于动态模型预测血管内皮因子抑制剂心血管不良反应风险的研究。第一负责人,重庆市科卫联合医学科研项目,2024.01-2025.12,2024QNXM016。
5. 基于机器学习的免疫性心肌炎风险预测模型构建及应用,2024.05-2026.05.吴阶平医学基金,320.6750.2024-6-46.
6. CXCL14基因单核苷酸多态性与伊马替尼相关皮疹发生的关联性分析及其机制研究。第一负责人,神经与肿瘤药物研发全国重点实验室开放研究课题,2025.01-2026.12,SKLSIM-2024079.
二、发表文章
1. A pharmacovigilance study of thromboembolism events associated with vascular endothelial growth factor receptor tyrosine kinase inhibitors based on FAERS database. Sci Rep. 2025;15(1):25120.
2. Prevention and treatment of anthracycline-induced cardiotoxicity:
a systematic review and network meta-analysis of randomized controlled trials. Cardiooncology. 2025; 11(1):66.
Assessing hemorrhagic risks in combination therapy: implications of angiogenesis inhibitors and immune checkpoint inhibitors.Front Immunol.2025; 10(16): 1-13.
4. Predicting survival benefits of immune checkpoint inhibitor therapy in lung cancer patients: a machine learning approach using real-world data. Int J Clin Pharm. 2025;47(4):981-989.
5. Cardiovascular adverse events associated with antibody-drug conjugates (ADCs): a pharmacovigilance study based on the FAERS database. Front Pharmacol. 2024;15:1-8.
6. Saikosaponin D Alleviates DOX-induced Cardiac Injury In Vivo and In Vitro. J Cardiovasc Pharmacol. 2022;79:558–567.
7. Irisin ameliorates angiotensin II‐induced cardiomyocyte apoptosis through autophagy. J Cell Physiol. 2019;234:17578–17588.
8. SIRT6 protects cardiomyocytes against ischemia/reperfusion injury by augmenting FoxO3a-dependent antioxidant defense mechanisms. Basic Res Cardiol. 2016;111:13.
9. PD-L1 抑制剂致1 例免疫性肝炎病例分析及药学监护. 中国药物警戒. 2021;18: 694-696.
10. microRNA-193b和microRNA-141在脓毒血症时基因启动子区甲基化状态. 生物学杂志. 2020;37:14-17.
11. PD-1 / PD-L1 抑制剂相关心肌炎不良反应—基于三大报告系统的真实世界研究.中国新药杂志. 2019;28:1404-1408.
12. Sirtuin家族与心血管疾病相关性研究进展.四川生理科学杂志.2019:41:48-50.
13. microRNA-193b和microRNA-141在脓毒血症休克小鼠组织中的表达变化及意义.生物技术通讯. 2018,29:593-597.