Huang B, Ren J, Ma Q, Yang F, Pan X, Zhang Y, Liu Y, Wang C, Zhang D, Wei L, Ran L, Zhao H, Liang C, Wang X, Wang S, Li H, Ning H, Ran A, Li W*(并列通讯), Wang Y*, Xiao B*. A novel peptide PDHK1-241aa encoded by circPDHK1 promotes ccRCC progression via interacting with PPP1CA to inhibit AKT dephosphorylation and activate the AKT-mTOR signaling pathway. Mol Cancer. 2024;23(1):34. (IF=37.3,中科院1区)
Yang F#, Ma Q#, Huang B, Wang X, Pan X, Yu T, Ran L, Jiang S, Li H, Chen Y, Liu Y, Liang C, Ren J, Zhang Y, Wang S, Li W*(并列通讯), Xiao B*. CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability. J Transl Med. 2023 Jun 20;21(1):402. (IF=7.4,中科院2区)
Pan X, Huang B, Ma Q, Ren J, Liu Y, Wang C, Zhang D, Fu J, Ran L, Yu T, Li H, Wang X, Yang F, Liang C, Zhang Y, Wang S, Ren J, Li W*(并列通讯), Wang Y*, Xiao B*. Circular RNA circ-TNPO3 inhibits clear cell renal cell carcinoma metastasis by binding to IGF2BP2 and destabilizing SERPINH1 mRNA. Clin Transl Med. 2022 Jul;12(7):e994. (IF=10.6,中科院1区)
Li W, Ma Q, Wang X, Tang M, Lin J*, Xiao B*. The Characteristics of Two Patients Co-Infected With SARS-CoV-2 and HIV in Wuhan, China. J Med Virol. 2021, 93(1): 85-88. (IF= 20.693)
Ran L#, Li W#(并列第一), Zhang H#, Lin J, Zhu L, Long H, Xiang L, Chen L, Li Q, Hu Y, Gong M, Zhao H, Xiao B. Identification of Plasma hsa_circ_0001230 and hsa_circ_0023879 as Potential Novel Biomarkers for Focal Segmental Glomerulosclerosis and circRNA-miRNA-mRNA network analysis. 2024 Apr 22. doi: 10.1159/000538825. (IF=2.8)
Targeted delivery of circPDHK1 siRNA via aptamer functionalized lipid nanoparticles inhibits ccRCC growth and migration[J].International Journal of Pharmaceutics, 2025, 677.DOI:10.1016/j.ijpharm.2025.125666. (IF=5.8)
CircABCA1 promotes ccRCC by reprogramming cholesterol metabolism and facilitating M2 macrophage polarization through IGF2BP3-mediated stabilization of SCARB1 mRNA[J].Molecular Cancer, 2025,24(1).DOI:10.1186/s 12943-025-02398-4. (IF=33.9)
二、承担和参与的科学研究项目
(1)重庆市科技局, 2026年重庆市科卫联合医学科研项目“原创新型核酸药物 AS1411-LNP/si-circPDHK1的构建及靶向治疗肾癌的临床前研究”,2026-01 至 2027-12, 10万元, 在研, 主持
(2)重庆市科技局,2026年重庆市自然科学基金“CircPFKFB3 编码新蛋白通过糖酵解-乳酸化修饰轴促进肾透明细胞癌恶性进展的分子机制研究”,2026-01 至 2028-12, 10万元, 在研, 主持
(3) 重庆市科技局, 重庆市科研机构绩效激励引导专项项目,cstc2022jxjl120012,hsa_circ_ 0001741通过结合IGF2BP2蛋白及靶mRNA形成三元复合物抑制ccRCC增殖的作用机制研究, 2023-01 至 2024-12, 20万元, 结题, 主持
(4) 重庆市科技局, 重庆市自然科学基金面上项目, cstc2020jcyj-msxmX0337, 新发现的环状RNA circ-DDX17作为蛋白诱饵竞争结合ELAVL1蛋白促进足细胞损伤及其在FSGS发病中的作用机制研究, 2020-07 至 2023-06, 10万元, 结题, 主持