王志增

学历:博士研究生

职称:副教授

职务:医学院医学公共实验中心副主任

邮箱:wzhzeng@cqu.edu.cn

研究方向:诊断试剂开发、疾病快速诊断、POCT探针制备等应用基础研究

简介

重庆大学硕士生导师,河南省优秀教师,全国优秀创新创业博士后。主持国家自然科学基金面上项目、科技部重大专项子课题等省部级及以上纵向项目12项,主持横向课题2项,主持科技成果转化3项。长期从事疾病快速诊断领域的研究和研发工作,围绕纳米硒探针展开应用基础研究。

    以第一或通讯作者在Science Translational Medicine、Biomaterials、Nano Materials Science等杂志发表SCI论文21篇,其中ESI热点论文1篇、ESI高被引3篇;以第一发明人授权专利20项,已转化10项;获重庆市科技进步一等奖、第二届全国博士后创新创业大赛银奖、河南省科技进步三等奖、重庆市首届医学科技创新成果转化大赛二等奖、第一届河南省博士后创新创业大赛银奖、河南省教育厅科技成果一等奖、河南省医学科技二等奖各1项。

学习经历

1. 2009.09-2014.07 兰州大学 博士(硕博连读)

2. 2005.09-2009.07 河南科技大学 学士


工作经历

1. 2023.07-至今  重庆大学医学院,副教授

2. 2021.06-2023.06  河南大学抗体药物开发技术国家地方联合工程实验室,副教授

3. 2014.07-2021.05  河南大学基础医学院/抗体药物开发技术国家地方联合工程实验室,讲师


研究项目

1)基于SeNPs淬灭QDs的荧光传感用于NAb动态衰减规律研究82472380国家自然科学基金面上项目2025.01-2028.12主持

2纳米硒标记单抗快速检测新技术、U1504823、国家自然科学基金河南联合基金、2016.01-2018.12主持

3)分钟级多重标志物筛查和快速检测2023YFC2307402,国家重点研发计划子课题,2023.12-2026.11主持

4细胞因子在脓毒症诊疗中的临床应用研究CSTB2023TIAD-LDX0028、重庆市科技局技术创新与应用发展专项面上项目、2023.09-2024.09主持

5纳米硒法联合假病毒对新冠中和抗体抵御不同突变株的评价和机制研究232300420051河南省自然科学基金面上项目、2023.01-2024.12主持

6纳米硒法新冠病毒及相关抗原的快速检测及应用、212102310174河南省科技厅科技研发专项科技攻关项目、2021.01-2022.12主持

7纳米硒法急性心梗快速检测试剂盒的研制、182102310154、河南省科技厅科技研发专项科技攻关项目、2018.01-2019.12主持

8血流感染病原微生物DNA纳米结构耦合微流控芯片的一体化检测系统研发研究、CSTB2023TIAD-KPX0063-2、重庆市科技局技术创新与应用发展专项重点项目课题、2023.10-2026.09主持

9)纳米硒法 AFP CEA 即时检测试剂的开发及应用2024MSXM053、重庆市科卫联合医学科研面上项目、2024.01-2025.12主持

10基于拉曼材料的抗SARS-CoV-2 RBD抗体检测技术开发22A320001河南省高校重点科研项目、2022.01-2023.12主持

11)基于拉曼技术的新冠疫苗接种效果评价体系建立、SBGJ202102194、河南省卫健委省部共建重点项目、2022.01-2024.12主持

12新型冠状病毒抗原检测试剂盒研发横向课题20224102020000872022.02-2022.12主持

13纳米硒法新冠中和抗体试剂盒开发、横向课题、2022.08-2023.07主持


发表论文

(1) Chunxia Chen#, Zhan Yang#, Yangguang Ren#, Menghan Xue#, Jinbo Wu, Jianing Ji, Yan Zhao, Ruyan Meng, Yao Ma, Xiaoquan Li, Yonghong Wang, Xiaohui Chen, Ziwei Li*, Xiaogang Lin*, Zhizeng Wang*, Yang Luo*. Precision antibody orientation on gold nanoparticles via pH control enables clinic-grade lateral flow detection of acute myocardial infarction. Nano Materials Science. 2026, 4.(中科院1TOPIF:17.9,封面论文)

(2) Qianqian Wu#, Xiaohui Chen#, Sitong Wang, Xing Wang, Zhixin Cha, Hengyi Chen, Yangguang Ren, Yao Luo, Xin Cui, Yan Zhao, Yufang Zhang, Yican Li, Zhongyao Ge, Sergio Benardini, Zhizeng Wang*, Jichun Yang*, Yang Luo*. Well-defined electronic configuration cyano-bridged bimetallic nanozyme for cancer catalytic-immunotherapy. Biomaterials. 2026,18: 123868.SCI 1TopIF12.9

(3) Lanju Wang#, Jianing Ji#, Yan Zhao#, Xiaohui Chen#, Jinbo Wu, Ruyan Meng, Yangguang Ren, Ying He, Guifang Long, Chunxia Chen*, Zhizeng Wang*, Yang Luo*, Shujun Shao*. PEG-modified selenium nanoparticles dramatically increases antibody binding sites for ultra-sensitive point-of-care detection of NT-proBNP. Analytical Chemistry. 2026, 11.SCI 1TOPIF:6.7Nature Index

(4) Weiqi Xie#, Jinbo Wu#, Xiaoyi Xie#, Mengli Wu, Menghan Zhang, Mengyao Zhang, Xiaoquan Li, Li Wang, Lanju Wang, Zhigang Liu,*, Zhizeng Wang*, Chunxia Chen*. Intelligent POCT for ovarian cancer: Dual-biomarker detection combined with ROMA risk assessment using selenium nanoparticle. Analytica Chimica Acta. 2026, 1404: 345434.SCI 1TopIF6.0

(5) Chunxia Chen#, Jingjing Ma#, Shujie Duan#, Menghan Xue, Zhan Yang, Ziwei MaJianing Ji, Yuanfang Ma, Guangchao Qing, Keying Guo, Wei Wu, Tianfeng Chen, Zhizeng Wang*, YangLuo*. Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation. Biomaterials. 2025, 318 : 123119. SCI 1TopIF12.8ESI高被引论文)

(6) Haoyang Xu#, Qi Chen#, Xianzhuo Meng#, Chao Yan, Bangben Yao , Zhaoran Chen , Zhizeng Wang* , Wei Chen*. CRISPR/Cas12a-mediated cyclic signal amplification and electrochemical reporting strategy for rapid and accurate sensing of Vibrio parahaemolyticus in aquatic foods. Biosensors and Bioelectronics. 2025, 268: 117284. SCI 1TopIF10.7

(7) Yuning Zhang#, Yanbing Lv#, Xinxin Chen#, Yingli Ye, Shenping Yu, Ning Li , Hongtao Yao, Zhizeng Wang*, Qitong Feng*, Ruili Wu*, Lin Song Li*. Ultrasensitive point-of-care multiplex diagnosis for influenza virus based robust quantum dot microsphere-lateral flow immunoassay. Biosensors and Bioelectronics. 2025, 273: 117187. SCI 1TopIF10.7

(8) Zhizeng Wang#, Zhi Zheng#, Hangzhan Hu#, Qianwen Zhou, Wei Liu, Xiaoquan Li, Zhigang Liu, Yaohui Wang*, Yuanfang Ma*. A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV‐2 IgM and IgG in human serum and blood. Lab on a Chip. 2020, 20: 4255-4261. SCI 1TopIF6.799

(9) Yaohui Wang#, Hailong Zhang#, Zhizeng Wang#, Yinxiang Wei#, Mingli Wang, Meichen Liu, Xuance Wang, Yinan Jiang, Gongning Shi, Dongmei Zhao, Zhengyan Yang, Zhiguang Ren, Jing Li, Zhenkai Zhang, Zhenfeng Wang, Bei Zhang, Beibei Zong, Xueke Lou, Chengguo Liu, Zihui Wang, Hao Zhang, Ningya Tao, Xuefang Li, Xingkun Zhang, Yafei Guo, Yang Ye, Yu Qi, Hui Li, Man Wang, Rongxin Guo, Guanchang Cheng Shulian Li, Jun Zhang, Guangchao Liu, Lihui ChaiQiang Lou, Xia Li, Xiukun Cui, Erhe Gao, Zheng Dong, Yanzhong Hu, Youhai H Chen*, Yuanfang Ma*. Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats. Science Translational Medicine. 202012(540): eaaw3172. SCI 1TopIF17.956

(10) Chunxia Chen#, Shujie Duan#, Jianing Ji#, Mengli Wu, Zhan Yang, Mengyang Cai, Menghan Xue, Lanju Wang, Rui Chen, Sima Yaron, Keying Guo*, Sergio Benardini*, Zhizeng Wang*, Yang Luo*. Structured protein probes modified with selenium nanoparticle for 1-minute measurement of SARS-CoV-2 antigen. Biosensors and Bioelectronics. 2025, 268: 116878. SCI 1TopIF10.7

(11) Yi Chen#, Hengyi Chen#, Xiaohui Chen#, Yufang Zhang, Wei Tu, Jiaxi Mo, Shanshan Tian, Chenyu Sun, Zhizeng Wang*, Jichun Yang*, Yang Luo*. Precision detection of hepatocellular carcinoma-associated telomerase RNA with SA@Comb-HCR nanosystem. Biosensors and Bioelectronics. 2024, 261: 116496. SCI 1TopIF12.6

(12) Zhigang Liu#, Jiahui Liang#, Hangzhan Hu#, Mengli Wu#, Jingjing Ma, Ziwei Ma, Jianing Ji, Hengyi Chen, Xiaoquan Li, Zhizeng Wang*, Yang Luo*. Development of an effective neutralizing antibody assay for SARS-CoV-2 diagnosis. International Journal of Nanomedicine. 2023, 18: 3125-3139.SCI 2TOPIF8.0

(13) Zhizeng Wang#, Qianwen Zhou#, Yafei Guo#, Hangzhan Hu, Zhi Zheng, Shulian Li, Yaohui Wang*, Yuanfang Ma*. Rapid detection of ractopamine and salbutamol in swine urine by immunochromatography based on selenium nanoparticles. International Journal of Nanomedicine. 2021, 16: 2059-2070. SCI 2TOPIF7.033

(14) Lanju Wang#, Mengli Wu#, Jingjing Ma#, Ziwei Ma, Jiahui Liang, Ningya Tao, Yangguang Ren, Shujun Shao, Xin Qi*, Zhizeng Wang*. Development of a point-of-care test based on selenium nanoparticles for heart-type fatty acid-binding proteins in human plasma and blood. International Journal of Nanomedicine. 2022, 17: 1273-1284. SCI 2TOPIF8.0

(15) Yangyang Wang, Kaixuan Zheng, Wenhao Zhan, Luyu Huang, Yidan Liu, Tao Li, Zhihui Yang, Qi Liao, Runhua Chen, Chaosheng Zhang, Zhizeng Wang*. Highly effective stabilization of Cd and Cu in two different soils and improvement of soil properties by multiple-modified biochar. Ecotoxicology and Environmental Safety. 2021, 207: 111294 SCI 2TOPIF7.129ESI高被引论文)

(16) Chunxia Chen#, Hangzhan Hu#, Xiaoquan Li#, Zhi Zheng, Zhizeng Wang*, Xuance Wang, Peiming Zheng, Facai Cui, Gang Li, Yaohui Wang, Zhigang Liu* and Yuanfang Ma*. Rapid Detection of Anti-SARS-CoV-2 antibody Using a Selenium Nanoparticle-based Lateral Flow Immunoassay. IEEE Transactions on NanoBioscience. 2022, 21(1): 37-43. SCI 3区,IF3.9ESI热点论文、ESI高被引论文)

(17) Chunxia Chen#, Zhan Yang#, Jingjing Ma#, Weiqi Xie, Zhizeng Wang*. Recent research progress on the biological functions, synthesis and applications of selenium nanoparticles. Journal of Chromatography B. 2025, 1252: 124448 SCI 3区,IF2.8

(18) Yang Zhao#, Xinyue Niu#, Hong Yang#, Jing Yang, Zhizeng Wang* and Qilin Wang*. Substrate- directed divergent synthesis of fused indole polycycles through Rh(ii)- catalyzed cascade reactions of bis(diazo)indolin- 2- ones. Chemical Communications. 2022, 58(61): 8576-8579. SCI 2TOPIF6.065

(19)Zhizeng Wang, Dejuan Zhi, Yang Zhao, Hailong Zhang, Xin Wang, Yi Ru, Hongyu Li*. Lateral flow test-strip based on colloidal selenium immunoassay for rapid detection of melamine in milk, milk powder and animal feed. International Journal of Nanomedicine. 2014, 9(1): 1699-1707. SCI 2区,IF4.32

(20) Zhizeng Wang, Jing Jing, Yangguang Ren, Yafei Guo, Ningya Tao, Qianwen Zhou, Hailong Zhang, Yuanfang Ma*, Yaohui Wang*. Preparation and application of selenium nanoparticles in a lateral flow immunoassay for clenbuterol detection. Materials Letters. 2019, 234: 212–215.SCI 3区,IF3.204

(21) Chunxia Chen#, Jiahui Liang#, Hangzhan Hu, Xiaoquan Li, Li Wang*, Zhizeng Wang*. Research progress in methods for detecting neutralizing antibodies against SARS-CoV-2. Analytical Biochemistry. 2023, 673: 115199. SCI 4区,IF3.191

(22) 孟如妍季家宁赵妍张宇芳王星王志增*基于侧向层析的即时检测在临床中的研究进展。重庆医科大学学报。2026 DOI10.13406/j.cnki.cyxb.003945

(23) 靖静王志增*侧向层析技术标记物研究进展生物医学工程学杂志2018354 661-664

(24) 陶宁亚,张贝,任阳光*,王志增*。急性心肌梗死检测方法研究进展,东南大学学报(医学版)。2018376):1085-1088

(25) 冀梦真,周倩文,陈晨,余品倩,尚佳铭,王志增*。不同加热方式对胶体金影响的比较研究河南大学学报(医学版)。2019383):188-191

授权专利(仅列出第一发明人)

(1)一种新型冠状病毒抗体检测试剂及其制备方法、新型冠状病毒抗体检测卡。专利号:ZL 202010158081.3

(2)一种用于盐酸克伦特罗检测的胶体硒、胶体硒标记物、检测卡及其制备方法、应用。专利号:ZL 201710343657.1

3一种胶体硒标记的抗HE4抗体、试剂盒及其制备方法专利号:ZL 201810196189.4

4)一种胶体金标记的抗HE4抗体试剂盒及其制备方法。专利号:ZL 201910675948.X

5)一种快速检测HE4CA125的纳米硒试剂盒。专利号:ZL 201910675929.7

6)一种部分覆膜检测试纸条。专利号:ZL 201922094687.0

7)一种多向联合检测试纸条。专利号:ZL201922093794.1

8)一种精准判读试剂盒。专利号:ZL 202021861962.3

9)一种内置稀释液仓的试剂盒。专利号:ZL 202023058458.2

10)一种滑动式检测试剂盒。专利号:ZL 202023068897.1

11一种快速判读的免疫层析试纸条。专利号:ZL 202121061191.4

12)一种便捷判读的试剂盒。专利号:ZL 202121065900.6

13一种通用型防压迫纸尿裤。专利号:ZL 202121207886.9

14一种舒适型透气纸尿裤。专利号:ZL 202121207467.5

15)一种双指标快速检测试纸条。专利号:ZL 201921108522.8

16)包装盒(SARS-CoV-2抗原检测试剂盒),专利号:ZL 202230137169.7

17包装袋(SARS-CoV-2抗原检测试剂盒),ZL 202230136709.X

18一种联合检测的免疫层析试纸条。专利号:ZL 201921108459.8

19)一种侧向层析试剂盒。专利号:ZL 201821528166.0

20一种定时检测的按压弹盖式试剂盒。专利号:ZL 202211433924.1

科技成果转化

1纳米硒法新型冠状病毒抗体检测试剂盒制备技术,20204102020000332021410202000042主持

2抗新型冠状病毒RBD金标抗体检测试剂盒制备技术2021410202000052主持

3)纳米硒试剂盒系列专利转化,主持

获奖及荣誉

(1)河南省科技进步奖三等奖(第一完成人)

(2)重庆市科技进步奖一等奖(第五完成人)

(3)重庆市首届医学科技创新成果转化大赛二等奖(第一完成人)

(4)河南省教育厅科技成果奖一等奖(第一完成人)

4)河南省医学科技奖二等奖(第一完成人)

5)开封市科技创新人才、开封市纳米硒医学应用科技创新团队负责人

6河南省优秀教师

7)河南省创新创业训练最佳导师奖

8)第二届全国博士后创新创业大赛银奖

9)第一届河南省博士后创新创业大赛银奖

10开封市青年岗位能手

11河南大学优秀共产党员

12)河南大学优秀工会会员(2019-20202021-2022

13)河南大学优秀硕士学位论文指导教师

14河南大学疫情防控工作首批先进个人

15中国(上海)国际发明创新展览会金奖

16)河南省第五届自然科学学术论文一等奖(第一作者)

17)河南省教育厅科技成果奖优秀科技论文一等奖(第一作者,2次)

18创之声第七届中国实验医学优秀论文奖(第一作者)

19建行杯六、七届中国国际互联网+大学生创新创业大赛全国银奖

20第四届中国创翼创业创新大赛(人社部)创翼之星奖

21笫十七届 挑战杯全国大学生外学术科技作品竞赛三等奖

22)第七届创客中国创新创业大赛创客组河南省赛一等奖(第一名)