洪慧慧

学历:博士研究生

职称:副研究员

研究方向:1.环境有害因素健康效应与机制研究 2.重金属代谢毒性特征及机制研究

学术兼职

中国毒理学会肝脏毒理专委会 委员

中国毒理学会神经毒理专委会 青年委员

中华医学会卫生毒理专委会 青年委员

重庆市预防医学会卫生毒理专委会 委员

重庆市神经科学学会 副秘书长


学习经历

2018.9-2023.6 浙江大学 劳动卫生与环境卫生学 博士

2013.9-2018.6 杭州师范大学 预防医学 学士

工作经历

2023.6-2025.8 重庆大学医学院 弘深青年教师/博士后

2025.9-至今  重庆大学医学院 副研究员


研究方向、教学课程

1.环境有害因素健康效应与机制研究

2.重金属代谢毒性特征及机制研究

科研成果:学术论文

1. Hong H#, Huang H, Li SA, Lin J, Luo K, Cao X, Cui F, Zhou Z, Ma H. Revealing Molecular Connections between Dissolved Organic Matter in Surface Water Sources and Their Cytotoxicity Influenced by Chlorination Disinfection. Environ Sci Technol. 2025 Feb 11;59(5):2754-2764. doi: 10.1021/acs.est.4c09795. Epub 2025 Jan 27. PMID: 39871532.

2. Huihui Hong#, Jia Xu, Haotian He,Xue Wang, Lingling Yang, Ping Deng, Lu Yang, Miduo Tan, Jingjing Zhang, Yudong Xug, Tong Tong, Xiqin Lin, Huifeng Pi,* Yuanqiang Lu*, Zhou Zhou*. Cadmium perturbed metabolomic signature in pancreatic beta cells correlates with disturbed metabolite profile in human urine. Environment International. 2022, 161: DOI: 10.1016/j.envint.2022.107139

3. Huihui Hong#, Yudong Xu, Jia Xu, Jingjing Zhang, Yu Xi, Huifeng Pi, Lingling Yang, Zhengping Yu, Qingqian Wu, Zhuoxian Meng, Shuzhen Xu, Yunzhao Ren, Wei-shuyi Ruan, Yuan-qiang Lu*, Zhou Zhou*. Cadmium exposure impairs pancreatic β-cell function and exaggerates diabetes by disrupting lipid metabolism. Environment International. 2021, 149: DOI: 10.1016/j.envint.2021.1064061.

4. Lin J, Li J, Liang Z, Yu H, Liu S, Zheng Q, Yu J, Du Z, Luo K, Yang X, Yang L, Deng P, Pi H, Yu Z, Zhou Z, Yuan W, Hong H*. Aflatoxin B1-induced lipid disturbance and neuroinflammation contribute to Alzheimer's disease-like neuropathology in C57BL/6J mice. Ecotoxicol Environ Saf. 2025 Nov 29;308:119495. doi: 10.1016/j.ecoenv.2025.119495. Epub ahead of print. PMID: 41319459.

5. Huihui Hong#, Xiqin Lin, Yudong Xu, Tong Tong, Jingjing Zhang, Haotian He, Lingling Yang, Yuanqiang Lu*, Zhou Zhou*. Cadmium induces ferroptosis mediated inflammation by activating Gpx4/Ager/p65 axis in pancreatic β-cells. Science of the Total Environment. 2022, 849: DOI: 10.1016/j.scitotenv.2022.157819

6. Hong H#, Li J, Tong T, Yang T, Wang H, Xu Y, Lin X, Lin J, Liu S, Luo K, Yu Z, Yuan W, Pi H, Zhou Z. Paraquat disrupts KIF5A-mediated axonal mitochondrial transport in midbrain neurons and its antagonism by melatonin. Sci Total Environ. 2024 Jul 15;934:173119. doi: 10.1016/j.scitotenv.2024.173119. Epub 2024 May 14. PMID: 38750743.

7. Hong H#, Liu S, Yang T, Lin J, Luo K, Xu Y, Li T, Xi Y, Yang L, Lu YQ, Yuan W, Zhou Z. Manganese exposure induces parkinsonism-like symptoms by Serpina3n-TFEB-v/p-ATPase signaling mediated lysosomal dysfunction. Cell Biol Toxicol. 2025 Jan 23;41(1):34. doi: 10.1007/s10565-025-09989-3. PMID: 39847159; PMCID: PMC11759460.

8. Xu Y#, Hong H#, Lin X, Tong T, Zhang J, He H, Yang L, Mao G, Hao R, Deng P, Yu Z, Pi H, Cheng Y, Zhou Z*. Chronic cadmium exposure induces Parkinson-like syndrome by eliciting sphingolipid disturbance and neuroinflammation in the midbrain of C57BL/6J mice. Environ Pollut. 2023 Sep 22;337:122606. doi: 10.1016/j.envpol.2023.122606. Epub ahead of print. PMID: 37742865.

9. Lin X, Xu Y, Tong T, Zhang J, He H, Yang L, Deng P, Yu Z, Pi H, Hong H*, Zhou Z*. Cadmium exposure disturbs myocardial lipid signature and induces inflammation in C57BL/6J mice. Ecotoxicol Environ Saf. 2023 Oct 15;265:115517. doi: 10.1016/j.ecoenv.2023.115517. Epub 2023 Sep 28. PMID: 37776818.

10. Huihui Hong#, Haotian He, Xiqin Lin, Tali Hayuehashi, Jia Xu, Jingjing Zhang, Yudong Xu, Tong Tong, Yuanqiang Lu*, Zhou Zhou*. Cadmium exposure suppresses insulin secretion through mtROS-mediated mitochondrial dysfunction and inflammatory response in pancreatic beta cells. Journal of Trace Elements in Medicine and Biology. 2022, 71: DOI: 10.1016/j.jtemb.2022.126952

11. Liu S, Deng P, Liu C, Hong H, Zheng Q, Lin J, Li J, Du Z, Yang L, Luo K, Yu H, Liang Z, Yu Z, Pi H, Zhou Z. Bisphenol S drives breast cancer metastasis by inhibiting dopamine receptor D2 to activate the Akt/GSK3β oncogenic axis. J Adv Res. 2025 Sep 23:S2090-1232(25)00744-1. doi: 10.1016/j.jare.2025.09.045. Epub ahead of print. PMID: 40998253.

12. Tong, T, Duan, WX, Xu, YD , Hong, HH, Xu, J, Fu, GY, Wang, X, Yang, LL, Deng, P, Zhang, JJ, He, HT, Mao, GF, Lu, YQ, Lin, XQ, Yu, ZP, Pi, HF, Cheng, Y*, Xu, S*C, Zhou Zhou*. Paraquat exposure induces Parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain. Environment International. 2022, 169: DOI: 10.1016/j.envint.2022.107512

13. Deng P, Li J, Lu Y, Hao R, He M, Li M, Tan M, Gao P, Wang L, Hong H, Tao J, Lu M, Chen C, Ma Q, Yue Y, Wang H, Tian L, Xie J, Chen M, Luo Y, Yu Z, Zhou Z*, Pi H*. Chronic cadmium exposure triggered ferroptosis by perturbing the STEAP3-mediated glutathione redox balance linked to altered metabolomic signatures in humans. Sci Total Environ. 2023 Sep 14;905:167039. doi: 10.1016/j.scitotenv.2023.167039. Epub ahead of print. PMID: 37716689.

14. Xi Y, Liu M, Xu S, Hong H, Chen M, Tian L, Xie J, Deng P, Zhou C, Zhang L, He M, Chen C, Lu Y, Reiter RJ, Yu Z, Pi H*, Zhou Z*. Inhibition of SERPINA3N-dependent neuroinflammation is essential for melatonin to ameliorate trimethyltin chloride-induced neurotoxicity. J Pineal Res. 2019 Oct;67(3):e12596. doi: 10.1111/jpi.12596. Epub 2019 Aug 6. PMID: 31332839.

15. He H, Lin X, Tong T, Xu Y, Hong H, Zhang J, Xu Y, Huang C*, Zhou Z*. Cadmium exposure impairs skeletal muscle function by altering lipid signature and inducing inflammation in C57BL/6J mice. Ecotoxicol Environ Saf. 2023 Jun 15;258:114986. doi: 10.1016/j.ecoenv.2023.114986. Epub 2023 May 8. PMID: 37163905.


承担和参与的科学研究项目

1. 国自然青年科学基金项目(c类,82404219;主持;30万)

2. 重庆市自然科学基金面上项目(CSTB2025NSCQ-GPX0769;主持;10万)

3. 中国博士后科学基金(2025T180205;主持;18万)

4. 国家资助博士后研究人员计划(B、C档)(GZC20233316;主持;24万)

5. 重庆市重点实验室开放课题(2025ZYBKFO1;主持;8万)

6. 教育部重点实验室开放课题 (2020DCKF001;主持;5 万)

7. 国家重点研发计划(2025YFC2511700;课题骨干;60万)

8. 国家自然科学基金面上项目 (82173468;参与;55 万)