孙中义

学历:博士研究生

职称:主任医师

职务:附属仁济医院泌尿生殖医学中心主任

邮箱:sun200801@hotmail.com

研究方向:焊接生物学的基础研究和医疗设备开发;男性生殖衰老的基础与转化研究

学术兼职

中华医学会男科学分会全国委员

中国性学会私密整形与产业分会主任委员

中国健康管理协会男性健康管理分会副主任委员

中国研究型医院学会泌尿外科分会全国委员

广东省医学会男科学专委会副主任委员

广东省医学会性医学专委会 副主任委员

深圳市医学会性医学分会主任委员


学习经历

1.2015.06-2015.12 北京大学第三医院进修生殖医学、男科学

2.2014.10-2015.01 美国康奈尔大学威尔医学院泌尿外科、生殖医学中心访问学者

3.2011.10-2012.11 美国迈阿密大学整形外科博士后研究

4.2004.07-2007.06 第三军医大学临床医学泌尿男科学博士

5.2002.07-2002.11 北京大学第一医院泌尿研究所进修泌尿外科以及男科学

6.1994.09-2001.07 第三军医大学临床医学七年制硕士


工作经历

1.2025.09-至今 重庆大学附属仁济医院泌尿生殖医学中心主任 主任医师、教授

2.2020.12-2025.08 深圳大学总医院泌尿外科主任 主任医师、教授

3.2018.06-2020.12 北京大学深圳医院泌尿外科、生殖中心副主任 主任医师、副教授

4.2015.01-2018.05 第三军医大学第三附属医院泌尿外科(肾移植、普通泌尿病区负责人)副主任 副主任医师、副教授

5.2010.08-2014.12 第三军医大学第三附属医院 副主任医师、副教授

6.2007.08-2010.07 第三军医大学第三附属医院 主治医师、讲师

7.1999.08-2007.07 第三军医大学第三附属医院 医师


研究方向、教学课程

1.焊接生物学的基础研究和医疗设备开发  

2.男性生殖衰老基础与转化研究


研究成果:学术论文

1.Yongyong Wang, Qi Zhou, Cong Huang, Xiaodong Li, Haining Liu*, Zhongyi Sun*, Baoquan Han*. Colony-stimulating factor-1 as a potential therapeutic target in asthenozoospermia. Reproductive Biology and Endocrinology. 2025, 23(1):135. (中科院一区Top期刊,IF=4.7,共同通讯作者)

2.Baoquan Han#, Lei Hua#, Shuai Yu, Wei Ge, Cong Huang, Yu Tian, Chunxiao Li, Jiamao Yan, Tian Qiao, Jiachen Guo, Dongliang Lu, Bin Wang, Diya Cai, Yunqi Zhang, Shaolin Liang, Jianjuan Zhao, Qi Hou*, Wei Shen*, Zhongyi Sun*. Revealing the core suppression effects of various Di (2-ethylhexyl) phthalate exposure on early meiosis progression in postnatal male mice via single-cell RNA sequencing. Ecotoxicology and Environmental Safety. 2025. 291: 117866. (中科院一区Top期刊,IF=6.2,第一通讯作者)

3.Baoquan Han, Yongyong Wang, Wei Ge, Junjie Wang, Shuai Yu, Jiamao Yan, Lei Hua, Xiaoyuan Zhang, Zihui Yan, Lu Wang, Jinxin Zhao, Cong Huang, Bo Yang, Yan Wang, Qian Ma, Yong Zhao, Hui Jiang, Yunqi Zhang, Shaolin Liang, Jianjuan Zhao, Zhongyi Sun*, Wei Shen#, Yaoting Gui#. Changes in seminal plasma microecological dynamics and the mechanistic impact of core metabolite hexadecanamide in asthenozoospermia patients. iMeta. 2024, e166. IF23.7,共同通讯作者)

4.Yu Tian, Jiachen Guo, Lei Hua, Yinuo Jiang, Wei Ge, Xiaoyuan Zhang, Diya Cai, Dongliang Lu, Bin Wang, Wei Shen, Zhongyi Sun, Baoquan Han*. Mechanisms of imbalanced testicular homeostasis in infancy due to aberrant histone acetylation in undifferentiated spermatogonia under different concentrations of Di(2-ethylhexyl) phthalate (DEHP) exposure. Environmental Pollution. 2024. 7: 123742. (中科院二区Top期刊,IF8.9

5.Baoquan Han, Feng Yue, Xiaojun Zhang, Kun Xu, Zhiying Zhang, Zhongyi Sun*, Lu Mu, Xiaoyu Li. Genetically engineering of Saccharomyces cerevisiae for enhanced oral delivery vaccine vehicle. Fish & shellfish immunology. 2024, 146:109425. (中科院一区Top期刊,IF4.7,第一通讯作者)

6.Zihang Mai, Di Yang, Dan Wang, Jingyi Zhang, Qi Zhou, Baoquan Han*, Zhongyi Sun*. A narrative review of mitochondrial dysfunction and male infertility. Translational Andrology and Urology. 2024, 13(9):2134-2145. (中科院三区期刊,IF=1.9,第一通讯作者)

7.Fanchun Zeng, Quanfu Cao, Fengwen Fu, Bin Wang*, Zhongyi Sun*. Biological welding: a rapid and bloodless approach to circumcision. World Journal of Urology. 2024, 43(1):25. (中科院二区期刊,IF2.8,第一通讯作者)

8.Lei Hua, Yinuo Jiang, Dongliang Lu, Bin Wang, Baoquan Han*, Junqing Hou*, Zhongyi Sun*. Advancements in semen sample analysis: evaluating the efficacy and progress in human DNA removal techniques. Journal of Men's Health. 2024, 20(7):88-95. (中科院四区期刊,IF=0.6,第一通讯作者)

9.Yuan Chen, Yinuo Jiang, Xiao Li, Bin Wang, Xiaofeng Guo, Zihang Mai, Weifen Deng, Yuanchang Zhu, Baoquan Han*, Zhongyi Sun*. Penile enhancement: A comprehensive and current perspective. Current Urology. 2024. (中科院四区期刊,IF=0.9,第一通讯作者)

10.Baoquan Han, Jiachen Guo, Bo Zhou, Chunxiao Li, Tian Qiao, Lei Hua, Yinuo Jiang, Zihang Mai, Shuai Yu, Yu Tian, Xiaoyuan Zhang, Dngliang Lu, Bin Wang, Zhongyi Sun*, Lan Li*. Chestnut polysaccharide rescues the damaged spermatogenesis process of asthenozoospermia-model mice by upregulating the level of palmitic acid. Frontiers in Endocrinology. 2023, 14: 1222635. (中科院二区期刊,IF5.2,共同通讯作者)

11.Fanchun Zeng, Chunrong Zhao, Rujie Wang, Lingyan Ren, Hao Qiu, Zhi Zou, Haibin Ding, Zhongyi Sun#, Jianmei Li#, Shiwu Dong#. Antagonizing exosomal miR-18a-5p derived from prostate cancer cells ameliorates metastasis-induced osteoblastic lesions by targeting Hist1h2bc and activating Wnt/β-catenin pathway. Genes & Diseases. 2022, 10(4):1626-1640. (中科院一区,IF7.243,共同通讯作者)

12.Zhongyi Sun#, Shuai Yu#, Yu Tian#, Baoquan Han, Yong Zhao, Yaqi Li, Yan Wang, Yujiang Sun, Wei Shen*. Chestnut polysaccharides rescue impaired spermatogenesis by adjusting gut microbiota and intestinal structure. Food & Function. 2021 Nov; 10.1039/D1FO03145G. (中科院一区,IF5.396,第一作者)

13.Baoquan Han#, Zihui Yan#, Shuai Yu#, Wei Ge, Yaqi Li, Yan Wang, Bo Yang, Wei Shen*, Hui Jiang*, Zhongyi Sun*. Infertility network and hub genes for nonobstructive azoospermia utilizing integrative analysis. Aging (Albany NY). 2021 Feb; 13(5):7052-7066. (中科院二区,IF5.682,第一通讯作者)

14.Baoquan Han#, Lu Wang#, Shuai Yu#, Wei Ge, Yaqi Li, Hui Jiang*, Wei Shen*, Zhongyi Sun*. One potential biomarker for teratozoospermia identified by in-depth integrative analysis of multiple microarray data. Aging (Albany NY). 2021 Mar; 13(7):10208-10224. (中科院二区,IF5.682,第一通讯作者)

15.Shuai Yu, Yong Zhao, Fali Zhang, Yaqi Li, Wei Shen, Zhongyi Sun*. Chestnut polysaccharides benefit spermatogenesis through improvement in the expression of important genes. Aging (Albany NY). 2020 Jun, 12(12):11431-11445. (中科院二区,IF4.831,第一通讯作者)

16.Zhongyi Sun, Pan Zhang, Jun-Jie Wang, Jing-Cai Liu, Lan Li, Wei Shen, Qiu-Yue Zhai. Melatonin alleviates meiotic defects in fetal mouse oocytes induced by Di (2-ethylhexyl) phthalate. Aging (Albany NY). 2018 Dec;10(12):4175-4187.IF5.515,第一作者)

17.Peng Wang, Yao Zhang, Jun Zhang, Jun Jiang, Fengshuo Jin*, Zhongyi Sun*. IL‑23 concentration‑dependently regulates T24 cell proliferation, migration and invasion and is associated with prognosis in patients with bladder cancer. Oncology reports. 2018 Dec; 40(6):3685-3693.IF3.041,第一通讯作者)

18.B Zhou, P Wang, W-J Xu, Y-M Li, D-L Tong, J Jiang, Z-Y Sun *. Correlations of glucose metabolism, insulin resistance and inflammatory factors with symptom score of patients with benign prostatic hyperplasia. European review for medical and pharmacological sciences. 2018 Aug; 22(16):5077-5081.IF2.721,第一通讯作者)

19.Jian Pang, Qingsong Zhou, Xiaofeng Sun, Lan Li, Bo Zhou, Fanchun Zeng, Yong Zhao, Wei Shen, Zhongyi Sun*. Effect of low-dose zearalenone exposure on reproductive capacity of male mice. Toxicology and applied pharmacology. 2017 Oct; 333:60-67.IF3.616,第一通讯作者)

20.Peng Wang, Bo Yang, Bo Zhou, Jun Zhang, Shujing Li, Jun Jiang, Zhongyi Sun*, Fengshuo Jin*. Distribution and expression profiles of dendritic cell subpopulations in human bladder cancer. International Journal of Clinical and Experimental Pathology. 2016; 9(7):7180-7187.IF1.706,共同通讯作者)

21. Bo Zhou, Peng Wang, Keqin Zhang, Feng-shuo Jin, Yan-feng Li, Jun Zhang, Zhongyi Sun*. Reduction of fertility in male mice immunised with of pSG.SS.C3d3.YL.Bin1b recombinant vaccine. European Journal of Contraception and Reproductive Health Care. 2015 Jan; 20(5):372-8.IF1.236,第一通讯作者)

22.Zhongyi Sun, Varsha R. Sinha, Ezekiel E. Young, Brian Bensadigh, Carmen Ceron, Bruce R. Kava, Jennifer N. Landon, Christopher J. Salgado. The Use of Bovine Collagen and Skin Graft for Reconstruction of the Glanspenis Following Cancer Resection. Open Journal of Urology. 2012 Oct; 2(1):216-218. (第一作者)

23.Xiao-Feng Sun#, Zhong-Yi Sun#, Bo Pan, Lan Li, Wei Shen. DNA methylation of PTEN gene promoter region is not correlated with urocystic tumorigenesis. African Journal of Biotechnology. 2012 Feb; 11(16):3868-3873.

24.Xiao-Feng Sun#, Zhong-Yi Sun#, Bo Pan, Lan Li, Wei Shen. Alteration in methylation pattern of oncogene Akt1 promoter region in bladder cancer. Molecular Biology Reports. 2012 May;39(5):5631-6. (共同第一作者)

25.Zhongyi Sun, Yanfen Li, Gang Wu, Xujun Xuan, Luofu Wang, Qiansheng Li, Peihe Liang, Fengshuo Jin. High ligation of internal spermatic vein under single-portTransumbilical laparoscopy in young patients. Scientific Research and Essays. 2011 Mar; 6(6):1281-1284. (第一作者)

26.Zhongyi Sun, Fengshuo Jin, Yanfeng Li, Jun Zhang. Immunocontraceptive Effect of DNA Vaccine Targeting Fertilin bin Male Mice. American journal of reproductive immunology (New York, N.Y. : 1989). 2010 Apr 1;63(4):282-90. (第一作者)

27.Zhongyi Sun, Yiguan Zhang, Wenqiang Liao, Luofu Wang, Qiansheng Li, Shujing Li, Fengshuo Jin.  LC–MS for in Vitro Determination of a Novel Epothilone D Derivative (Epo D 7-HD) in Human Plasma. Chromatographia. 2010 May; 71(9):923-926(第一作者)

28.LL Sun#, ZY Sun#, P Zhang, XW Zhai, J Tang, QJ Pan, QH Shi, W Shen. Effect of insulin on oogenesis from mouse fetal germ cells in a serum-free 3D culture system. Reproductive biomedicine online. 2010 Jan;20(1):11-25. (第一作者)


承担和参与的科学研究项目

1.深圳市医学研究专项,基于队列人群的环境新污染物对睾丸早衰的影响及表观遗传机制研究(B2403006),2025.01-2027.12,主持。

2.深圳市科技创新委员会国际合作研究项目,人体组织器官快速焊接多功能手术机器人基础与应用研究(GJHZ20220913143006011),2023.08.25-2025.08.31,主持。

3.深圳大学医工交叉研究基金,人体组织器官多功能快速焊接手术机器人研发及生物学机制研究(2023YG018),2023.09-2026.08,主持。

4.国家自然科学基金面上项目,DEHP暴露影响丝氨酸代谢阻抑生精细胞第一次减数分裂进程的机制,82271637,2023.01-2026.12,主持。

5. 深圳科技创新委员会面上项目,DEHP暴露诱导SHMT1表达下调损害生精细胞减数分裂早期发生的机制,JCYJ20220531103004008,2022.10.28-2025.10.31,主持。

6.中国人民解放军总装备部重点课题,野战条件下生物组织快速焊接设备关键技术研究,2017.01-2018.12,主持。

7.第三军医大学科技成果转化基金项目,人体组织器官多功能焊接仪研发,2016XZH16,2017.01-2019.12,主持。

8.大坪医院,野战外科研究所第三批“1135”优秀人才项目,2016.01-2018.12,主持。

9.人力资源社会保障部2014年度留学人员科技活动择优资助项目,人体组织器官无痕快速焊接仪联合研发,SQS2014RR125,2014.04-2017.04,主持。

10.科技部重大国际合作专项课题,人体组织器官无痕快速焊接仪联合研发,2014DFR30860,2014.04-2017.04,主持。

11.国家自然基金,基于Bin1b的雄性免疫节育DNA疫苗构建及其效应研究,81100546,2012.01-2014.12,主持。

12.重庆市自然基金,C3d3介导的Bin1b疫苗构建及免疫节育效应研究,CSTC,2010BB5162,2010.10-2013.10,主持。

13.第三军医大学校级课题,睾丸内睾酮浓度、血睾酮浓度与精子发生的关系研究,2005.01-2007.12,主持。


奖励与荣誉

1.2019年深圳市地方领军人才

2.2019年广东省杰出青年医学人才

3.2023年中国临床医学奖-医疗技术创新奖

4.2024年俄罗斯工程院院士