一、近期文章
1.Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan. Gut–Metabolome–Proteome Interactions in Age-Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi-Omics Analyses. Advanced Science. 2026.
2.Hong, Huihui., Liu, Sicheng., Yang, Ting., Lin, Jinxian., Luo, Kun.. Manganese exposure induces parkinsonism-like symptoms by Serpina3n-TFEB-v/p-ATPase signaling mediated lysosomal dysfunction. Cell biology and toxicology, 2025.
3.Jiang, X., Ke, J., Liu, Y., Luo, X., Feng, M., Mo, H., & Yuan, W. (2025). Identifying a gene signature for age-related hearing loss through machine learning and revealing the effect of the CTSS on the mice cochlea. Biogerontology, 26(3), 119.
4.Geng, G., Xu, Y., Hu, Z., Wang, H., Chen, X., Yuan, W., & Shu, Y. (2025). Viral and non-viral vectors in gene therapy: current state and clinical perspectives. EBioMedicine, 118, 105834. Advance online publication.
5.Lin, J., Hong, H., Liu, S., Liang, Z., Zheng, Q., Luo, K., Li, J., Du, Z., Yu, J., Yang, L., Deng, P., Pi, H., Yu, Z., Yuan, W., & Zhou, Z. (2025). Aflatoxin B1 exposure induces Alzheimer's disease like pathology by disrupting redox homeostasis and activating ferroptotic signals in C57BL/6 J mice.The Science of the total environment, 970, 179049.
6.Ke, J., Liu, Y., Yang, T., Zhang, J., Jiang, X., & Yuan, W. (2025). High-fat diet attenuates vestibular and auditory dysfunction in aged mice via macrophage-mediated anti-inflammatory mechanisms. Experimental gerontology, 211, 112930. Advance online publication.https://doi.org/10.1016/j.exger.2025.112930.
7.Chen, Z., Zhou, X., Yang, T., Liu, X., Zhang, J., Feng, M., Kuang, S., & Yuan, W. (2025). Characteristics and Cell Lineage Tracing of Neurod1-Cre and Neurod1-iCreER Mice Targeting Cochlear Neurons. Neuroscience bulletin, 10.1007/s12264-025-01567-1. Advance online publication.
8.Juhong Zhang,Lili Xiang,Wenfang Sun,Menglong Feng,Zhiji Chen,Hailan Mo,Haizhu Ma,Li Yang,Shaojing Kuang,Yaqin Hu,Jialin Guo1,Yijun Li1,Wei Yuan.Single cell RNA sequencing provides novel cellular transcriptional profiles and underlying pathogenesis of presbycusis.BMC Med Genomics,2024 Sep 30;17(1):237.
9.Juhong Zhang,Wenfang Sun,Shaojing Kuang,Qiang Gan,Hai Li,Haizhu Ma,Guijun Yang,Jialin Guo,Yong Tang,Wei Yuan.miR-130b-3p involved in the pathogenesis of age-related hearing loss via targeting PPARγ and autophagy.Hearing Research. 2024 Aug:449:109029.
10.Huihui Hong,Jingdian Li,Tong Tong,Ting Yang,Hui Wang,Yudong Xu,Xiqin Lin,Jinxian Lin,Sicheng Liu,Kun Luo,Zhengping Yu,Wei Yuan,Huifeng Pi,Zhou Zhou.Paraquat disrupts KIF5A-mediated axonal mitochondrial transport in midbrain neurons and its antagonism by melatonin.Science of the Total Environment .2024 Jul 15:934:173119.
11.Wu Xiaolu,Yang Congwen,Li Zhongwan,et al.Dihydroartemisinin inhibits HNSCC invasion and migration by controlling miR-195-5p expression.Heliyon.2024;10.
12.Chanyuan Zhang,Ting Yang,Xiaoqin Luo,Xiaoqing Zhou,Menglong Feng,Wei Yuan.The chromatin accessibility and transcriptomic landscape of the aging mice cochlea and the identification of potential functional super-enhancers in age-related hearing loss. Clin Epigenetics,2024 Jul 4;16(1):86.
13.Hu, Y., Luo, X., Chen, H., Ke, J., Feng, M., & Yuan, W. (2024). MiR-204-5p regulates SIRT1 to promote the endoplasmic reticulum stress-induced apoptosis of inner ear cells in C57BL/6 mice with hearing loss. PloS one, 19(11), e0309892.
14.Zhang J, Ma H, Yang G, Ke J, Sun W, Yang L, Kuang S, Li H, Yuan W. Differentially expressed miRNA profiles of serum-derived exosomes in patients with sudden sensorineural hearing loss. Front Neurol. 2023 Jun 2;14:1177988.
15.Luo X, Hu Y, Zhou X, Zhang C, Feng M, Yang T, Yuan W. Potential roles for lncRNA Mirg/Foxp1 in an ARHL model created using C57BL/6J mice. Hear Res. 2023 Oct;438:108859.
16.Feng M, Zhou X, Hu Y, Zhang J, Yang T, Chen Z, Yuan W. Comprehensive Transcriptomic Profiling of m6A Modification in Age-Related Hearing Loss. Biomolecules. 2023 Oct 18;13(10):1537.
17.Yang T, Chen HJ, Zhang CY, He D, Yuan W. Association of blood heavy metal concentrations with hearing loss: a systematic review and meta-analysis. Public Health. 2024 Feb;227:95-102.
18.Ke J, Xiong J, Zhang J, Ma H, Yuan W. Pediatric granular cell tumor of the larynx: A case report and literature review. J Cancer Res Ther. 2023 Aug;19(4):1070-1073.
19.Zhou X-Q, Zhang Q-L, Yuan W, et al. Cortical Responses Correlate with Speech Performance in Pre-lingually Deaf Cochlear Implant Children. Front Neurosci 2023, 19, 1126813.
20.Jiang X, Ke J, Jia L, An X, Ma H, Li Z, Yuan W. A novel cuproptosis-related gene signature of prognosis and immune microenvironment in head and neck squamous cell carcinoma cancer. J Cancer Res Clin Oncol. 2023 Jan;149(1):203-218.
二、发明专利
1.实用新型专利：一种气管导管扩展接头，专利号：ZL 2011 2 0093993.3
2.实用新型专利：一种可视化吸痰器，专利号：ZL 2011 2 0093991.4
3.实用新型专利：一种微型耳内成像装置，专利号：ZL 2020 2 0535562.7
4.实用新型专利：一种便携式耳显微消毒器械盒，专利号：ZL 2020 2 0534769.2
5.实用新型专利：一种耳科剥离器，专利号：ZL 202422964846.9
三、近期课题
1.国家自然基金:Gga3介导的SGN高尔基体功能异常在老年性聋中的作用机制研究(项目编号：82571321),2026年01月-2029年12月。
2.国家自然基金:lncRNA-Malat1介导miR-30b/140调节内毛细胞突触蛋白Dynamin的机制研究(项目编号：81873702),2018年08月-2022年12月。
3.国家耳鼻咽喉疾病临床医学研究中心开放课题:A1+多组学探寻老年性聋诊疗相关标志物(项目编号:2024KF008),2024.05-2027.05。
4.重庆市技术创新与应用发展重点专项项目：AI+老龄视听感知性疾病诊治体系建立及防控技术研究(项目编号：CSTB2023TIAD-KPX0059),2023.9.20-2026.9.20
5.重庆市科卫联合医学科研重大项目：听力残疾精准防控研究与应用示范（项目编号：2022DBXM006）2022.01.01-2024.12.31。
6.重庆英才包干项目：miR-130b靶向PPAR-γ/AQP7调控毛细胞线粒体自噬在老年性聋发病中的机制研究（项目编号：cstc2022ycjh-bgzxm0126）2022-2024。
7.重庆市自然科学基金：LncRNA PVT1/miR-7658靶向ENPP2调控自噬依赖性铁死亡在老年性聋发病中的机制研究（项目编号：CSTB2022NSCQ-MSX0553）2022.08.01-2025.07.31。
8.川渝科技创新合作计划项目：M2型巨噬细胞通过IGF-1/IGF-1R通路抑制“非专职”吞噬细胞促炎表型以影响分泌性中耳炎炎症进展的机制研究（项目编号：2024YFHZ0076），2024.1.1-2025.12.31。
9.科技援疆项目：老年听力衰老-代谢性疾病共病分级防治模式的创建与推广应用（项目编号：2025E02043）2025.11-2027.10。
四、获奖情况
1.2000年度军队“三等功”一次
2.2008年度重庆市科技进步三等奖
3.2013年度军队科技进步二等奖
4.2016、2020年度重庆市研究生创新创业大赛一等奖优秀指导教师
5.2021年度重庆英才
6.2022年度重庆市首席专家工作室领衔专家2023年度重庆好医生
7.2024年度第四批重庆市学术技术带头人
8.2024年度重庆市首届医学科技创新成果转化大赛二等奖
9.2025年度重庆市科技进步奖一等奖
10.2025年度新重庆杰出人才奖
