张坤

学历:博士研究生

职称:副研究员

职务:附属三峡医院老年疾病临床医学研究中心

研究方向:智能仿生纳米药物递送系统构建与应用

学术任职

European Cells & Materials青年编委

Interdisciplinary Medicine青年编委

《检验医学与临床》青年编委


学习经历

1. 2017.09–2021.12,重庆大学,生物医学工程专业,博士

2. 2014.09–2017.06,重庆大学,生物学专业,硕士

3. 2010.09–2014.07,临沂大学,生物技术专业,学士


工作经历

2022.01-今 重庆大学附属三峡医院,副研究员


研究方向

智能仿生纳米药物递送系统构建与应用


成果

发表论文:

[1] Zhang Kun; Liang Yi; Chen Qiao; Zhang Shirong; Liu Yanbing; Wu Wei; Zhu Li; Qu Kai; Qin Xian; Chen Yidan; Sun Da; Qiu Xu; Ye Minjun; Li Jiawei; Yan Fei; Lang Chunhui; Xu Lixin; Xiao Bo; Liu Jinyao; Wu Wei, Orchestrating Gut Disorders by Oral Delivery of a Living-Synthetic Hybrid Hydrogel, ACS Nano, 2025, 19(30): 2782527844.Q1IF16

[2] Zhang Kun; Zhu Li; Zhong Yuan; Xu Lixin; Lang Chunhui; Chen Jian; Yan Fei; Li Jiawei; Qiu Juhui; Chen Yidan; Sun Da; Wang Guixue; Qu Kai; Qin Xian; Wu Wei, Prodrug Integrated Envelope on Probiotics to Enhance Target Therapy for Ulcerative Colitis, Advanced Science, 2023, 10(4): 22054222205435.Q1IF14.1

[3] Zhang Kun; Wang Shunxi; Qu Kai; Zhao Yi; Feng Qian; Wu Wei; Qin Xian, pH triggered hierarchical responsive release of RVT to promote diabetic wound healing, Chemical Engineering Journal, 2026, 528: 172650172663.Q1IF13.2

[4] Zhang Kun; Qin Xian; Qiu Juhui; Sun Tong; Qu Kai; Din Ahmad Ud; Yan Wenhua; Li Tianhan; Chen Yidan; Gu Wei; Rao Xiancai; Wang Guixue, Desulfovibrio desulfuricans aggravates atherosclerosis by enhancing intestinal permeability and endothelial TLR4/NF-κB pathway in Apoe mice, Genes & Diseases, 2021, 10(1): 239253.Q1IF9.4

[5] Qin Xian; Zhang Kun; Qiu Juhui; Wang Nan; Qu Kai; Cui Yuliang; Huang Junli; Luo Li; Zhong Yuan; Tian Tian; Wu Wei; Wang Yi; Wang Guixue, Uptake of oxidative stress-mediated extracellular vesicles by vascular endothelial cells under low magnitude shear stress, Bioactive Materials, 2022, 6(9): 397410.Q1IF20.3

[6] Qin Xian; Zhu Li; Zhong Yuan; Wang Yi; Wu Guicheng; Qiu Juhui; Wang Guixue; Qu Kai; Zhang Kun*; Wu Wei*, Spontaneously Right-Side-Out-Orientated Coupling-Driven ROS-Sensitive Nanoparticles on Cell Membrane Inner Leaflet for Efficient Renovation in Vascular Endothelial Injury, Advanced Science, 2023, 10(6): 22050932205107.Q1IF14.1

[7] Qin Xian; Zhu Li; Zhong Yuan; Wang Yi; Luo Xiaoshan; Li Jiawei; Yan Fei; Wu Guicheng; Qiu Juhui; Wang Guixue; Qu Kai; Zhang Kun*; Wu Wei*, Universal cell membrane camouflaged nano-prodrugs with right-side-out orientation adapting for positive pathological vascular remodeling in atherosclerosis, Chemical Science, 2024, 15(20): 75247544.Q1IF7.4

[8] Chen Qiao; Duan Xinmei; Yu Yao; Ni Rongrong; Song Guojing; Yang Xu; Zhu Li; Zhong Yuan; Zhang Kun*; Qu Kai*; Qin Xian*; Wu Wei*, Target Functionalized Carbon Dot Nanozymes with Dual-Model Photoacoustic and Fluorescence Imaging for Visual Therapy in Atherosclerosis, Advanced Science, 2023, 11(6): 23074412307458.Q1IF14.1

[9] Chen Qiao; Yang Xu; Yu Yao; Duan Xinmei; Ni Rongrong; Song Guojing; Zhu Li; Zhong Yuan; Qu Kai; Qin Xian; Zhang Kun*; Luo Yang*; Wu Wei*, Biomimetic Cerium-Assisted Supra-Carbon Dots Assembly for Reactive Oxygen Species-Activated Atherosclerosis Theranostic, Small, 2024, 21(8): 24089802408998.Q1IF12.1

[10] Qin Xian; Zhu Li; An Xuan; Zhang Cheng; Li Jiawei; Yan Fei; Zhang Wenjin; Qu Kai; Zhang Kun*; Wu Wei*; Wu Guicheng*, Hybrid cell membranes camouflaged copper-loaded nano-prodrug for tumor angiogenesis inhibition and cell cuproptosis, Chemical Engineering Journal, 2024, 493: 152323152337.Q1IF13.2


专利

1.一种基于透明质酸和碳点掺杂的响应型活菌递送水凝胶制备方法及应用,发明专利,专利号:CN202510901200.2

2.前药封装的工程化益生菌及其制备方法与应用,发明专利,专利号:CN202211403974.5

3.红细胞膜自发定向包被ROS响应的纳米前药及其应用,发明专利,专利号:CN202211361359.2

4.一种狗粪便污染检测试剂盒及其制备与应用,发明专利,专利号:201610167582.1

5.一种用于狗粪便污染检测的试剂盒及其制备与应用,发明专利,专利号201610167403.4


主持项目

1.中国博士后科学基金面上项目,工程化益生菌治疗溃疡性结肠炎的研究(课题编号:2022M720574),2023.01-2024.06,8万元,主持

2.新重庆青年创新人才项目,益生菌递送系统(课题编号:CSTB2025YITP-QCRCX0037),2025.11-2028.10,30万,主持

3.重庆市教育委员会科学技术研究项目,病灶靶向前药封装益生菌治疗溃疡性结肠炎的研究(课题编号:KJZD-K202500105),2025.07-2028.06,5万元,主持

4.重庆市万州区科卫联合重点项目,多效益生元水凝胶协同前药增强溃疡性结肠炎治疗的应用研究(课题编号:wzwjw-kw2024002),2025.01-2026.12,20万元,主持



获奖

1.2023年,中国重庆市万州区委组织部 重庆市万州区人力资源和社会保障局,万州区第五批“平湖英才”