主任/教授
学习经历
2013.12—2015.01 美国纽约大学访问学者
2003.09—2006.07 第三军医学大学医学免疫学研究生，基础医学博士1998.09—2001.07 第三军医学大学病原生物学研究生，基础医学硕士1990.09—1995.07 第三军医学大学临床医学系，医学学士
工作经历
2011.10-至今 第三(陆军)军医大学病原生物学教研室 教授、主任
2008.08-2011.09 第三军医大学病原生物学教研室 副教授、主任
2006.10-2008.07 第三军医大学病原生物学教研室 副教授、副主任
2001.10-2006.09 第三军医大学病原生物学教研室 讲师
1995.09-2001.09 第三军医大学病原生物学教研室 助教
研究方向、教学课程
研究方向：重要虫媒病疟疾等的感染与免疫，包括疟疾等疫苗研制及其保护性免疫机制，以及疟原虫的免疫逃避或抑制策略
教学课程:1.人体寄生虫学(本科生) 2.基础医学前沿(基础医学八年制)
成果
一、文章
Y. Fu, Y. Ding, Q. Wang, F. Zhu, Y. Tan, X. Lu, B. Guo, Q. Zhang, Y. Cao, T. Liu, L. Cui, W. Xu.Blood-stage malaria parasites manipulate host innate immune responses through the induction of sFGL2.Science Advances, 2020, 6, eaay9269
Fu Y, Lu X, Zhu F,Liu T, Xu, W. Improving the immunogenicity and protective efficacy of a whole‐killed malaria blood‐stage vaccine by chloroquine.Parasite Immunology. 2020;42:e12682
Zhou D, Zheng H, Liu Q, Lu X, Deng X, Jiang L,Xu, W, Dai, J. Attenuated plasmodium sporozoite expressing MAGE-A3 induces antigenspecific CD8+ T cell response against lung cancer in mice.Cancer Biol Med. 2019; 16: 288-98. (Co-corresponding author)
Liu, T,Cheng, X.Ding, Y. Zhu, F. Fu, Y. Peng, X. Xu, W. PD-1 deficiency promotes TFH cells expansion in ITV-immunized mice by upregulating cytokines secretion.Parasite & Vectors, 2018, 11(1):397
Zhu, F., T. Liu, C. Zhao, X. Lu, J. Zhang, andW. Xu. Whole-Killed Blood-Stage Vaccine-Induced Immunity Suppresses the Development of Malaria Parasites in Mosquitoes.TheJournal of Immunology 2017,198: 300-307.
Zhao, C., T. Liu, T. Zhou, Y. Fu, H. Zheng, Y. Ding, K. Zhang, andW. Xu. The rodent malaria liver stage survives in the rapamycin-induced autophagosome of infected Hepa1-6 cells.Scientific Reports 2016,6: 38170.
Lu X, Liu T, Zhu F, W. Xu.A whole-killed, blood-stage lysate vaccine protects against the malaria liver stage.Parasite Immunology. 2016 Sep 16. doi: 10.1111/pim.12386.
Zheng, H., Z. Tan, T. Zhou, F. Zhu, Y. Ding, T. Liu, Y. Wu, andW. Xu. The TLR2 is activated by sporozoites and suppresses intrahepatic rodent malaria parasite development.Scientific Reports2015,5: 18239.
Tan, Z., T. Zhou, H. Zheng, Y. Ding, andW. Xu. Malaria DNA vaccine gp96-CSP elicits both CSP-specific antibody and CD8 T cell response.Parasitology Research. 2015,Jun;114(6):2333-9
Ding, Y., Y. Qiu, L. Zou, Z. Tan, J. Dai, andW. Xu. Three conserved MyD88-recruiting TLR residues exert different effects on the human TLR4 signaling pathway.Immunological Research. 2015. Jun;62(2):213-21
Liu, T., Lu, X., Zhao, C., Fu, X., Zhao, T.,Xu, W. PD-1 deficiency Enhances Humoral Immunity of Malaria infection-treated vaccine.Infection and Immunity. 2015. May;83(5):2011-7
Zheng,H., Tan, Z.., Xu,W. Immune Evasion Strategies of Pre-Erythrocytic Malaria Parasites.Mediators of Inflammation. 2014. http://dx.doi.org/10.1155/2014/362605
Liu,T. Xu,G. Guo, B. Fu,Y. Qiu,Y. Ding, Y. Zheng,H., Fu, X., Wu, Y., Xu, W. An essential role for C5aR signaling in the optimal induction of a malaria-specific CD4+ T cell response by a whole killed blood-stage vaccine.TheJournal of Immunology.2013.191(1) 178-186.
Qiu,Y., Ding, Y., Zou, L., Tan, Z., Liu, T.,Fu, X., Xu, W. Divergent roles of amino acid residues inside and outside the BB loop affect human Toll-like receptor (TLR)2/2, TLR2/1 and TLR2/6 responsiveness.Plos one, 2013, 8(4) : e61508 .
Qi, Y., Zhu, F., Li, J., Fu, Y., Pattaradilokrat, S., Hong, L., Liu, S., Huang, F., Xu, W.,Su, X. Z. 2013. Optimized protocols for improving the likelihood of cloning recombinant progeny from Plasmodium yoelii genetic crosses.Experimental Parasitology 133:44-50. (co-corresponding author)
Fu, Y., Ding,Y., Zhou, T., Fu, X., Xu, W. Plasmodium yoelii blood-stage primes macrophage-mediated innate immune response through modulation of toll-like receptor signalling.Malaria Journal 2012,11:104.
Ding, Y., Huang, X., Liu, T.,Fu, Y., Tan, Z., Zheng, H., Zhou, T., Dai, J., Xu, W. The Plasmodium Circumsporozoite Protein, a Novel NF-kappaB Inhibitor, Suppresses the Growth of SW480. Pathol Oncol Res. 2012.18(4):895-902
Fu, Y., Ding, Y., Zhou,T., Ou, Q., Xu, W. Comparative Histopathology of Mice Infected with the 17xl and 17xnl Strains of Plasmodium Yoelii.Journal of Parasitology, 2012,98(2): 310–315
Xu, W.,Wang, X., Qi, J., Duan, J., Huang. F. The influence of kupffer cell immune modulators on the development of Plasmodium liver stage.Experimental Parasitology. 2010;126(2):254-8.
Chen, J., Xu, W., Zhou, T.,Ding, Y.,Duan, J.,and Huang, F. Inhibitory role of toll-like receptors agonists in Plasmodium yoelii liver stage development.Parasite Immunology, 2009, 31, 466–473. (Co-first author)
Xu, W.,Wang, L., Wang, H.,Wang, Y.,Liang,Y., Zhao, T., Wu, Y. TLR2 and TLR4 agonists synergistically up-regulate SR-A in RAW264.7 through p38.Molecular Immunology. 2007; 44, 2315-2323
Xu, W.,Zhang, J.,Zhou, T., Huang, F., Duan, J., Wang, Y., Qiu, Z.,Xia,L. Plasmodium yoelii: Contribution of oocysts melanization to natural refractoriness of Anopheles dirus. Expl Parasitol. 2007,116: 433–439
Xu, W., Huang, F., Hao, H., Duan, J., Qiu, Z. Two serine proteases from Anopheles dirus haemocytes exhibit changes in transcript abundance after infection of an incompatible rodent malaria parasite, Plasmodium yoelii. Veterenary Parasitology. 2006; 94 (139) 93-101.
二、专利
(1) 徐文岳; 朱锋, 疟疾红内期灭活全虫疫苗的新用途, 2015.7.15, 中国, CN201510190955.2
(2) 徐文岳; 卢潇, 一种具有预治作用的新型疟疾全虫灭活疫苗, 2016.2.3, 中国, CN201510882354.8
(3) 徐文岳; 丁艳, 疟原虫环子孢子蛋白抗肿瘤增殖和迁移的新用途 , 2007.11.2,中国, CN200810233209.7
三、项目
(1)国家自然科学基金重点项目：子孢子活化肝细胞内补体及其促进肝期疟原虫发育的机制，2019/01-2023/12，293万，在研，主持
(2)国家自然科学基金面上项目：肝期约氏疟原虫ΔCSP下调自噬相关蛋白在其抑制IFN-γ杀伤EEF中的作用和机制，2017/01-2020/12，57万，在研，主持
(3)国家自然科学基金面上项目：子孢子感染诱导肝细胞自噬并促进其发育的分子机制研究，2015/01-2018/12，72万，已结题，主持
(4)国家自然科学基金面上项目：C5a/C5aR信号在约氏疟原虫减毒子孢子疫苗诱导小鼠产生保护性免疫中的作用和机制，2013/01-2016/12，70万，已结题，主 持
(5)全军十二五重点项目分课题：免疫组学在病原防控中的应用，2011/01-2015/12, 65万，已结题，主持
(6)国家自然科学基金面上项目：致死株17XL疟原虫TLR5激动剂的分离和鉴定及其功能的初步研究，2010/01-2012/12，32万，已结题，主持
(7)国家科技部973项目子课题：疟原虫感染的免疫应答及调控机制，2009/01-2011/12，30万，已结题，主持
(8)国家自然科学基金面上项目：Toll-like receptor及其胞内主要信号子的下调与疟原虫成份诱导DC耐受的研究，2008/01-2010/12，35万，已结题，主持
(9)重庆市自然科学基金重点项目：基于活化TLR受体的新型靶向DC疟疾脂质体疫苗的实验研究,，2008/01-2010/12，10万，已结题，主持。
(10)国家自然科学基金青年科学基金项目：疟原虫逃避或抑制按蚊黑化包被反应分子机制的研究，2003/01-2005/12，21万，已结题，主持
四、获奖
(1)黄复生;徐文岳; 张健; 张锡林; 王英; 杨松; 郝宏兴; 陈继德; 周桃莉。 不同媒介按蚊对疟原虫易感或抗性分子机制的研究, 2010年，军队科技进步二等奖
(2)黄复生; 杨松;徐文岳; 郝宏兴; 张健; 王英; 周桃莉; 段建华; 邱宗文。疟原虫孢子增殖的影响因素和卵囊黑化机理的研究, 2005年，军队科技进步二等奖
