国家高层次人才，教授、博士生导师，重庆大学“弘深杰出学者”

学习经历

2002.09-2005.06，中国人民解放军第三军医大学，劳动卫生与环境卫生学，博士

1999.09-2002.06，中国人民解放军第三军医大学，劳动卫生与环境卫生学，硕士

1993.09-1998.07，中国人民解放军第三军医大学，检验医学，学士

工作经历

2024.12-至今，重庆大学医学院党委委员、副院长，教授、博导

2023.08-2024.12，重庆大学医学院党总支委员、副院长，教授、博导

2022.05-2023.08，重庆大学医学院，教授、博导

2017.11-2022.05，浙江大学医学院环境医学系主任、“百人计划”特聘研究员、博导

2012.09-2017.11，中国人民解放军第三军医大学预防系劳动卫生学教研室，教授、博导

2009.09-2012.09，中国人民解放军第三军医大学预防系劳动卫生学教研室，副教授、硕导

2012.03-2012.06，法国波尔多第一大学IMS实验室，教育部公派高级访问学者

2006.12-2009.02，美国密西根州立大学公卫学院，博士后

2005.08-2009.08，中国人民解放军第三军医大学预防系劳动卫生学教研室，讲师

学术任职

中国毒理学会（国家一级学会） 理事

中国毒理学会表观遗传毒理专业委员会 副主任委员/常委

中华预防医学会卫生毒理专业委员会 副主任委员/常委

中国环境诱变剂学会生物标志物专业委员会 副主任委员/常委

重庆市神经科学学会 秘书长/常委

研究方向、教学课程

研究方向：

1. 环境与职业有害因素健康危害效应、与疾病的关联和毒理效应机制以及防护新策略

2. 环境与职业有害因素暴露与神经退行性疾病关联机制与防治

教学课程：劳动卫生学、环境卫生学、卫生毒理、医学科研方法

成果（1.文章2.专利3.项目4.获奖）：

近五年发表的部分论文（*通讯作者#第一作者）：

1. Ping Deng, Huadong Zhang, Liting Wang, Sheng Jie, Qi Zhao, Fengqiong Chen, Yang Yue, Hui Wang, Li Tian, Jia Xie, Mengyan Chen, Yan Luo, Zhengping Yu, Huifeng Pi*, Zhou Zhou*. Long-term cadmium exposure impairs cognitive function by activating lnc-Gm10532/m6A/FIS1 axis-mediated mitochondrial fission and dysfunction. Science of the Total Environment. 2023, 858: DOI: 10.1016/j.scitotenv.2022.159950

2. Haotian He, Xiqin Lin, Tong Tong, Yudong Xu, Huihui Hong, Jingjing Zhang, Yongjin Xu, Cong Huang *, Zhou Zhou*. Cadmium exposure impairs skeletal muscle function by altering lipid signature and inducing inflammation in C57BL/6J mice. Ecotoxicology and Environmental Safety. 2023，258：DOI：10.1016/j.ecoenv.2023.114986.

3. Yang Yue, Huadong Zhang, Ping Deng, Miduo Tan, Chengzhi Chen, Bo Tang, Jingdian Li, Fengqiong Chen, Qi Zhao, Ling Li, Rongrong Hao, Hui Wang, Yan Luo, Li Tian, Jia Xie, Mengyan Chen, Zhengping Yu, Zhou Zhou*, Huifeng Pi*. Environmental cadmium exposure facilitates mammary tumorigenesis via reprogramming gut microbiota-mediated lutamine metabolism in MMTV-Erbb2 mice. Science of the Total Environment. 2023,897: DOI：10.1016/j.scitotenv.2023.165348.

4. Yang Yue, Miduo Tan, Yan Luo, Ping Deng, Hui Wang, Jingdian Li, Rongrong Hao, Li Tian, Jia Xie, Mengyan Chen, Zhengping Yu, Zhou Zhou*, Huifeng Pi*. miR-36145-p downregulation promotes cadmium-induced breast cancer cell proliferation and metastasis by targeting TXNRD1. Ecotoxicology and Environmental Safety. 2022, 247: DOI: 10.1016/j.ecoenv.2022.114270

5. Zhixin He, Yajing Zhang, Huijie Zhang, Chao Zhou, Qinlong Ma, Ping Deng, Muxue Lu, Zhenlin Mou, Min Lin, Lingling Yang, Yanqi Li, Yang Yue, Huifeng Pi, Yonghui Lu, Mindi He, Lei Zhang, Chunhai Chen,* Zhou Zhou*, Zhengping Yu*. NAC antagonizes arsenic-induced neurotoxicity through TMEM179 by inhibiting oxidative stress in Oli-neu cells. Ecotoxicology and Environmental Safety. 2022, 223: DOI: 10.1016/j.ecoenv.2021.112554

6. Tong, T, Duan, WX, Xu, YD , Hong, HH, Xu, J, Fu, GY, Wang, X, Yang, LL, Deng, P, Zhang, JJ, He, HT, Mao, GF, Lu, YQ, Lin, XQ, Yu, ZP, Pi, HF, Cheng, Y*, Xu, SC*, Zhou Zhou*. Paraquat exposure induces Parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain. Environment International. 2022, 169: DOI: 10.1016/j.envint.2022.107512

7. Huihui Hong, Xiqin Lin, Yudong Xu, Tong Tong, Jingjing Zhang, Haotian He, Lingling Yang, Yuanqiang Lu*, Zhou Zhou*. Cadmium induces ferroptosis mediated inflammation by activating Gpx4/Ager/p65 axis in pancreatic β-cells. Science of the Total Environment. 2022, 849: DOI: 10.1016/j.scitotenv.2022.157819

8. Zhixin He, Yudong Xu, Qinlong Ma, Chao Zhou, Lingling Yang, Min Lin, Ping Deng, Zhiqi Yang, Mingyue Gong, Huijie Zhang, Muxue Lu, Yanqi Li, Peng Gao, Yonghui Lu, Mindi He, Lei Zhang, Huifeng Pi, Kuan Zhang, Song Qin, Zhengping Yu*, Zhou Zhou*, Chunhai Chen*. SOX2 modulated astrocytic process plasticity is involved in arsenic-induced metabolic disorders. Journal of Hazardous Materials. 2022, 435: DOI: 10.1016/j.jhazmat.2022.128942

9. Tengfei Fan, Xiaoning Wang, Sheng Zhang, Ping Deng, Yi Jiang, Yidan Liang, Sheng Jie, Qing Wang, Chuwen Li, Guocai Tian, Zhen Zhang, Zhenhu Ren, Bo Li, Yanrong Chen, Zhijing He, Yan Luo, Mingliang Chen, Hanjiang Wu, Zhengping Yu, Huifeng Pi*, Zhou Zhou* and Zhiyuan Zhang*. NUPR1 promotes the proliferation and metastasis of oral squamous squamous cell carcinoma cells by activating TFE3-dependent autophagy. Signal Transduction and Targeted Therapy. 2022, 7(1): DOI: 10.1038/s41392-022-00939-7

10. Yang Yue, Ping Deng, Heng Xiao, Miduo Tan, Hui Wang, Li Tian, Jia Xie, Mengyan Chen, Yan Luo, Liting Wang, Yidan Liang, Huifeng Pi*, Zhou Zhou*, Zhengping Yu*. N6-methyladenosine-mediated downregulation of miR-374c-5p promotes cadmium-induced cell proliferation and metastasis by targeting GRM3 in breast cancer cells. Ecotoxicology and Environmental Safety. 2022, 229: DOI: 10.1016/j.ecoenv.2021.113085

11. Huihui Hong, Haotian He, Xiqin Lin, Tali Hayuehashi, Jia Xu, Jingjing Zhang, Yudong Xu, Tong Tong, Yuanqiang Lu*, Zhou Zhou*. Cadmium exposure suppresses insulin secretion through mtROS-mediated mitochondrial dysfunction and inflammatory response in pancreatic beta cells. Journal of Trace Elements in Medicine and Biology. 2022, 71: DOI: 10.1016/j.jtemb.2022.126952

12. Huihui Hong, Jia Xu, Haotian He,Xue Wang, Lingling Yang, Ping Deng, Lu Yang, Miduo Tan, Jingjing Zhang, Yudong Xug, Tong Tong, Xiqin Lin, Huifeng Pi,* Yuanqiang Lu*, Zhou Zhou*. Cadmium perturbed metabolomic signature in pancreatic beta cells correlates with disturbed metabolite profile in human urine. Environment International. 2022, 161: DOI: 10.1016/j.envint.2022.107139

13. Yidan Liang, Huifeng Pi, Lingzhi Liao, Miduo Tan, Ping Deng, Yang Yue, Yu Xi , Li Tian, Jia Xie, Mengyan Chen, Yan Luo, Mingliang Chen, Liting Wang, Zhengping Yu, Zhou Zhou*. Cadmium promotes breast cancer cell proliferation, migration and invasion by inhibiting ACSS2/ATG5-mediated autophagy. Environmental Pollution. 2021, 273: DOI: 10.1016/j.envpol.2021.116504

14. Yidan Liang, Lai Yi, Ping Deng, Liting Wang, Yang Yue, Hui Wang, Li Tian, Jia Xie, Mengyan Chen, Yan Luo, Zhengping Yu, Huifeng Pi*, Zhou Zhou*. Rapamycin antagonizes cadmium-induced breast cancer cell proliferation and metastasis through directly modulating ACSS2. Ecotoxicology and Environmental Safety. 2021, 224: DOI: 10.1016/j.ecoenv.2021.112626

15. Ping Deng, Miduo Tan, Wei Zhou, Chunhai Chen, Yu Xi, Peng Gao, Qinlong Ma, Yidan Liang, Mengyan Chen, Li Tian, Jia Xie, Mengyu Liu, Yan Luo, Yanqi Li, Lei Zhang, Liting Wang, Youlong Zeng, Huifeng Pi*, Zhengping Yu*, Zhou Zhou*. Bisphenol A promotes breast cancer cell proliferation by driving miR-381-3p-PTTG1-dependent cell cycle progression. Chemosphere. 2021, 268: DOI: 10.1016/j.chemosphere.2020.129221

16. Chao Zhou, Mengyu Liu, Xiang Mei, Qian Li, Wenjuan Zhang, Pingeng, Zhixin He, Yu Xi, Tong Tong, Huifeng Pi, Yonghui Lu,hunhaihen, Lei Zhang, Zhengping Yu*, Zhou Zhou*, Mindi He*. Histone hypoacetylation contributes to neurotoxicity induced by chronic nickel exposure in vivo and in vitro. Science of the Total Environment. 2021, 783: DOI: 10.1016/j.scitotenv.2021.147014

17. Huihui Hong, Yudong Xu, Jia Xu, Jingjing Zhang, Yu Xi, Huifeng Pi, Lingling Yang, Zhengping Yu, Qingqian Wu, Zhuoxian Meng, Shuzhen Xu, Yunzhao Ren, Wei-shuyi Ruan, Yuan-qiang Lu*, Zhou Zhou*. Cadmium exposure impairs pancreatic β-cell function and exaggerates diabetes by disrupting lipid metabolism. Environment International. 2021, 149: DOI: 10.1016/j.envint.2021.106406

18. Mengyu Liu, Huifeng Pi, Yu Xi, Liting Wang, Li Tian, Mengyan Chen, Jia Xie, Ping Deng, Tao Zhang, Chao Zhou, Yidan Liang, Lei Zhang, Mindi He, Yonghui Lu, Chunhai Chen, Zhengping Yu* and Zhou Zhou*. KIF5A-dependent axonal transport deficiency disrupts autophagic flux in trimethyltin chloride-induced neurotoxicity. Autophagy. 2021, 17(4): 903-924

19. Qinlong Ma，Ping Deng，Min Lin, Lingling Yang , Le Li, Lu Guo, Lei Zhang, Mindi He, Yonghui Lu, Huifeng Pi, Yanwen Zhang, Zhengping Yu, Chunhai Chen* and Zhou Zhou*. Long-term bisphenol A exposure exacerbates diet-induced prediabetes via TLR4-dependent hypothalamic inflammation. Journal of Hazardous Materials. 2021, 402: DOI: 10.1016/j.hazmat.2020.123926

20. Ping Deng, Qinlong Ma, Yu Xi, Lingling Yang, Min Lin, Zhengping Yu, Chunhai Chen* and Zhou Zhou*. Transcriptomic insight into cadmium-induced neurotoxicity in embryonic neural stem/progenitor cells. Toxicology in Vitro. 2020, 62: DOI: 10.1016/j.tiv.2019.104686

21. Mindi He, Chao Zhou, Yonghui Lu, Ling Mao, Yu Xi, Xiang Mei, Xue Wang, Lei Zhang, Zhengping Yu and Zhou Zhou*. Melatonin Antagonizes Nickel-Induced Aerobic Glycolysis by Blocking ROS-Mediated HIF-1α/miR210 /ISCU Axis Activation. Oxidative Medicine and Cellular Longevity. 2020, 2020: DOI:10.1155/2020/5406284

22. Li Pang, Ping Deng, Yi-Dan Liang, Jing-Yu Qian, Li-Chuan Wu, Ling-Ling Yang, Zheng-Ping Yu, Zhou Zhou*. Lipoic acid antagonizes paraquat-induced vascular endothelial dysfunction by suppressing mitochondrial reactive oxidative stress. Toxicology Research. 2019, 8(6): 918-927

23. Huifeng P, Mengyu Liu, Yu Xi ,Mengyan Chen, Li Tian, Jia Xie, Mingliang Chen, Zhen Wang, Min Yang, Zhengping Yu, Zhou Zhou* and Feng Gao*. Long-term exercise prevents hepatic steatosis: a novel role of FABP1 in regulation of autophagy-lysosomal machinery. FASEB Journal. 2019, 33(11): 11870-11883

24. Yu Xi, Mengyu Liu, Shuzhen Xu, Huihui Hong, Mengyan Chen, Li Tian, Jia Xie, Ping Deng, Chao Zhou, Lei Zhang, Mindi He, Chunhai Chen, Yonghui Lu, Russel J. Reiter, Zhengping Yu, Huifeng Pi, Zhou Zhou*. Inhibition of SERPINA3N-dependent neuroinflammation is essential for melatonin to ameliorate trimethyltin chloride-induced neurotoxicity. Journal of Pineal Research. 2019, 67(3): DOI: 10.1111/jpi.12596

25. Pi H, Li M, Zou L, Yang M, Deng P, Fan T, Liu M, Tian L, Tu M, Xie J, Chen M, Li H, Xi Y, Zhang L, He M, Lu Y, Chen C1, Zhang T, Wang Z, Yu Z, Gao F, Zhou Zhou*. AKT inhibition-mediated dephosphorylation of TFE3 promotes overactive autophagy independent of MTORC1 in cadmium-exposed bone mesenchymal stem cells. Autophagy. 2019, 15(4): 565-582

26. Pi H, Wang Z, Liu M, Deng P, Yu Z, Zhou Zhou* and Gao F*. SCD1 activation impedes foam cell formation by inducing lipophagy in oxLDL-treated human vascular smooth muscle cells. Journal of Cellular and Molecular Medicine. 2019, 23(8): 5259-5269

27. Pi H, Li M, Xie J, Yang Z, Xi Y, Yu Z* and Zhou Zhou*. Transcription factor E3 protects against cadmium-induced apoptosis by maintaining the lysosomal-mitochondrial axis but not autophagic flux in Neuro-2a cells. Toxicology Letters. 2018, 295: 335-350

28. Tengfei Fan, Huifeng Pi, Min Li, Zhenhu Ren, Zhijing He,Feiya Zhu, Li Tian, Manyu Tu, Jia Xie, Mengyu Liu, Yuming Li, Miduo Tan, Gaoming Li, Weijia Qing, Russel J. Reiter, Zhengping Yu*, Hanjiang Wu*, Zhou Zhou*. Inhibiting MT2-TFE3-dependent autophagy enhances melatonin-induced apoptosis in tongue squamous cell carcinoma. Journal of Pineal Research. 2018, 64(2): DOI: 10.1111/jpi.12457

科研项目

1. 国家级基金项目：

主持国家自然科学基金优秀青年基金项目1项、面上项目2项；主持国家重点基础研究计划“973计划”子课题1项；

2. 省或市级基金项目：

主持重庆市杰出青年基金1项，主持中国人民解放军“十三五”后勤科研重大项目1项。

获奖

2017年 中国人民解放军军队科技进步二等奖1项（第二完成人）