许成雄

编辑:dhj 发布时间:2020-09-23 17:04

教授

学习经历

2001-2006 韩国首尔大学博士

1997-2000 延边大学硕士

1993-1997 延边大学学士

工作经历

2020.09-至今,重庆大学医学院,教授

2016.08-2020.08,陆军医科大学大坪医院肿瘤中心,研究员

2015.08-2016.07,陆军医科大学大坪医院肿瘤中心,副研究员

2010.05–2015.07,美国H. Lee墨菲特癌症研究中心,博士后、助理研究员

2009.01–2010.04,美国埃默里大学Winship肿瘤研究所,博士后

2006.08-2008.12,韩国BK21工程,博士后

研究领域

1.肿瘤转移和复发机制研究

2.肿瘤化疗和免疫治疗耐药机制研究

3.非编码RNA在肿瘤中的功能机制研究

4.天然抗癌药物的抗癌分子机制研究

教学课程

1.本科生:人体功能学(生理学)、机能实验学

2.研究生:分子与细胞

近五年论文(通讯)

1.Jiang T, Jin H, Ji X, Zheng X,Xu CX#, Zhang PJ#. Drivers of centrosome abnormalities: senescence progression and tumor immune escape. Semin Cancer Biol. 2025, 110:56-64 (IF:12.1)

2.Luo H, Hu B, Gu XR, Chen J, Fan XQ, Zhang W, Wang RT, He XD, Guo W, Dai N, Jian D, Li Q#,Xu CX#, Jin H#. The miR-23a/27a/24-2 cluster drives immune evasion and resistance to PD-1/PD-L1 blockade in non-small cell lung cancer. Mol Cancer, 2024, 23:285 (IF:27.7)

3.LiQ, Luo H, Dai FQ, Wang RT, Fan XQ, Luo YY, Deng MS, Wang Y, Long T, Guo W, Xu Bo#,Xu CX#, Jin H#. SAMD9 promotes postoperative recurrence of esophageal squamous cell carcinoma by stimulating MYH9-mediated GSK3β/β-signaling. Adv Sci. 2023,10:e2203573 (IF: 17.5)

4.Li Q, Deng MS, Wang RT, Luo H, Luo YY, Zhang DD, Chen KJ, Cao XF, Yang GM, Zhao TM, Xu B,Xu CX#, Wang JM#. PD-L1 upregulation promotes drug-induced pulmonary fibrosis by inhibiting vimentin degradation. Phamacol Res. 2023, 187:106636 (IF:10.3)

5.Luo H, Shan J, Zhang H, Song G, Li Q#,Xu CX#. Targeting the epigenetic processes to enhance antitumor immunity in small cell lung cancer. Semin Cancer Biol. 2022, 86:960-70 (IF:17)

6.Li Q, Luo H, Luo YY, Zhang W, Hong HM, Deng MS, Wang Y, Xu B, Song GB#,Xu CX#. Plumbagin-loaded ZIF-90 nanoparticles suppress gastric cancer progression by targeting the YAP1 signaling. Chem Eng J. 2022, 437:135369 (IF:16.7)

7.Li Q, Zhou ZW, Lu J, Luo H, Wang SN, Peng Y, Deng MS, Song GB, Wang JM, Wei X, Wang JM, Wei X, Wang D#, Westrover KD#,Xu CX#. PD-L1 P146R is prognostic and a negative predictor of response to immunotherapy in gastric cancer. Mol Ther. 2022. 30:621-31(IF:12.9)

8.Li Q, Zhou ZW, Duan W, Qian CY, Wang SN, Zi D, Wang JM, Mao CY, Song G, Wang D#, Westover KD#,Xu CX#. Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT. J Exp Clin Cancer Res. 2021, 40:220 (IF:12.7)

9.Zhou ZW*, Ambrogio C*, Bera AK*, Li Q, Li XX, Li L, Son J, Gondi S, Li J, Campbell E, Jin H, Okoro JJ,Xu CX#, Janne PA#, Westover KD#. KRASQ61 preferentially signals through MAPK in a RAF dimer-dependent manner in non-small cell lung cancer.Cancer Res. 2020 Sep 1, 80:3719-3731 (IF:13.3)

10.Jin H, Jang Y, Cheng N, Li Q, Cui PF, Zhou ZW, Jiang HL, Westover KD, Tan QY, andXu CX. Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression. J Exp Clin Cancer Res.2019, 38(1):165 (IF:12.7)