学习经历
2015/09-2019/06 陆军军医大学 病理与病理生理学博士
2013/09-2015/06 陆军军医大学 药理学硕士
2009/09-2013/06 湖北中医药大学 中药学学士
工作经历
2021/01-至今， 重庆大学医学院
研究方向
白血病的发生发展机制
纳米靶向递送系统在肿瘤治疗方面的应用
成果
一、代表性论文
1. Xiaoye Hu, Shuangnian Xu, Yibiao Chen, Ziyi Gao, Yunong Li, Jinjiao Hu, Xiuning Huang, Yanhao Zhang, Xiuxing Jiang, Lirong Li, Chong Yang, Jieping Chen, Ning Gao. Depletion of Ars2 inhibits cell proliferation and leukemogenesis in acute myeloid leukemia by modulating the miR-6734-3p/p27 axis.
Leukemia 2018 Dec 5. doi:10.1038/s41375-018-0301-z (IF=9.944)
2. Yibiao Chen, Xiaoye Hu, Yunong Li, Hongwei Zhang, Ruoqiu Fu, Yanxia Liu, Jinjiao Hu, Qin Deng, Qingsong Luo, Dunke Zhang, Ning Gao & Hongjuan Cui. Ars2 promotes cell proliferation and tumorigenicity in glioblastoma through regulating miR-6798-3p.
Sci Rep 2018 Oct 22; 8(1):15602.(IF=4.011)
3. Jing Zhou, Guobing Li, Yi Zheng, Han-Ming Shen, Xiaoye Hu, Qian-Liang Ming, Cheng Huang, Peng Li, and Ning Gao. A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission.
Autophagy 2015; 11(8):1259-1279.(IF=11.1).
4. Guobing Li, Hongwei Zhang, Ruoqiu Fu, Xiaoye Hu, Lei Liu, Yunong Li, Yanxia Liu, Xing Liu, Jinjiao Hu, Qin Deng, Qingsong Luo, Rong Zhang and Ning Gao Mitochondrial fission and mitophagy depend on cofilin-mediated actin depolymerization activity at the mitochondrial fission site.
Oncogene.2018;37:1485-1502. (IF=6.854).
5. Yunong Li, Xiuxing Jiang, Yanhao Zhang, Ziyi Gao, Yanxia Liu, Jinjiao Hu, Xiaoye Hu, Lirong Li, Jingshan Shi and Ning Gao. Nuclear accumulation of UBC9 contributes to SUMOylation of lamin A/C and nucleophagy in response to DNA damage.
J Exp Clin Cancer Res 2019 Feb 11; 38(1): 67.(IF=6.217).
6. Yi Zheng, Qin Ouyang, Ruoqiu Fu, Lei Liu, Hongwei Zhang, Xiaoye Hu, Yanxia Liu, Yingchun Chen and Ning Gao. The cyclohexene derivative MC-3129 exhibits antileukemic activity via RhoA/ROCK1/PTEN/PI3K/Akt pathway-mediated mitochondrial translocation of cofilin.
Cell Death Dis 2018 May 29;9(6): 656.(IF=5.638).
7. Ruoqiu Fu, Qin Deng, Hongwei Zhang, Xiaoye Hu, Yunong Li, Yanxia Liu, Jinjiao Hu, QingsongLuo,Yanhao Zhang, Xiuxing Jiang, Lirong Li, Chong Yang and Ning Gao. A novel autophagy inhibitor berbamine blocks SNARE-mediated autophagosomelysosome fusion through upregulation of BNIP3.
Cell Death Dis 2018 Feb 14;9(2):243.(IF=5.638).
8. Lei Liu, Guobing Li, Li Q, Jin Z, Zhang L, Jing Zhou, Xiaoye Hu, Ting Zhou, Jieping Chen and Ning Gao. Triptolide induces apoptosis in human leukemia cells through caspase-3-mediated ROCK1 activation and MLC phosphorylation.
Cell death & disease. 2013;4:e941. (IF=5.638).
9. Guobing Li, Qi Cheng, Lei Liu, Ting Zhou, Chanyu Shan, Xiaoye Hu, Jing Zhou, Ehu Liu , Peng Li and Ning Gao. Mitochondrial translocation of cofilin is required for allylisothiocyanate-mediated cell death via ROCK1/PTEN/PI3K signaling pathway.
Cell Commun Signal. 2013;11:50. (IF=5.324).
二、参与课题
1. 国家自然科学基金：Cofilin线粒体转位通过影响线粒体分裂调控细胞凋亡的分子机制研究，编号31571425，2016.01-2019.12，65万元，（参与人）
