陆军军医大学基础医学教学实验中心主任、兼任研究生导师、教授
邮箱：lihongli@tmmu.edu.cn
学习经历
1、1986/09-1992/06，第三军医大学临床医学6年制毕业，获学士学位。
2、1994/09-1997/06，第三军医大学硕士研究生，获医学硕士学位
3、2000/09-2003/06，第三军医大学博士研究生，获医学博士学位。
4、2008/02-2009/10，美国哈佛大学医学院、波士顿布莱根妇女医院麻醉系，博士后。
5、2015/01-2016/01，受教育部“青年骨干教师计划”资助在美国德克萨斯A&M大学、生物技术研究院，访问学者。
工作经历
1、1992/07-2019/04，陆军军医大学组织胚胎学教研室，历任助教、讲师、副教授、副主任/教授/博士生导师；
2、2019/05-今，陆军军医大学基础医学教学实验中心主任、教授、博士生导师；
3、2021-今，重庆大学医学院兼聘硕士研究生导师
研究方向、教学课程
专业方向为：基础医学、人体解剖与组织胚胎学。
研究方向为神经系统早期发育与干细胞分化调控：围绕神经系统胚胎早期发育与相关疾病防治，探讨钙离子通道相关蛋白时空表达及其作用，以深入阐明脑发育的细胞分子过程和相关疾病的发生机制。关注纳米钙信号变化在调控神经干细胞/少突前体细胞的增殖分化所涉及的下游信号通路及细胞凋亡等的相关机制。实验室仪器设备齐全，能够完成适用于培养细胞、活细胞成像、切片/组织标本、胚胎的光学成像、电生理等相关研究。
从事教学科研工作30年，一贯坚持“高标准、高质量”实施理念。是《组织学与胚胎学》、《基础医学综合实验》的主讲教员。获得军队院校“育才银奖”、获原总后勤部和重庆市“优秀教师”称号。是大学“教学明星”和“教学标兵”。注重教学经验总结，获得包括军队、重庆市和大学各级教学成果一等奖、二等奖等奖项。2021年作为课程负责人申报课程被评为“军队精品课程”。2016年入选国家科技部和教育部评审专家，并参加科技部“干细胞研究重大专项”“国家重点研发计划政府间重点专项”、“政府间国际合作重大项目”等评审。近年已获得国家自然科学基金等各级研究基金项目共9项。代表性论著发表在Cell Chemistry Biology，Journal of Biological Chemistry，Proc Natl Acad Sci ，ACS Chemical neuroscience, Brain Research等国际杂志。获得发明专利授权1项。
成果
一、文章
Ø 1. Chuncha Bao, Chengqi He, Bin Shu, Tao Meng, Qiyan Cai, Baichuan Li, Guangyan Wu, Bin Wu, Hongli Li*. (2021) Aerobic exercise training decreases cognitive impairment caused by demyelination by regulating ROCK signaling pathway in aging mice. Brain Res Bull 168:52-622.
Ø 2. Hongyu Zhong, Xiang Li , Wanqi Zhang, Xiaoxiao Shen, Yuangang Lu* and Hongli Li *. (2021) Efficacy of a New Non-drug Acne Therapy: Aloe Vera Gel Combined With Ultrasound and Soft Mask for the Treatment of Mild to Severe Facial Acne. Frontiers in Medicine 8 :662640
Ø 3.Zhen-zhen Liu, Xiao-ning Liu, Rui-cheng Fan, Yu-ping Jia, Qing-ke Zhang, Xin-qing Gao, Yu-qing Wang, Meng-qing Yang, Li-zhen Ji, Yong-qing Zhou, Hong-li Li*, Ping Li* and Bo Tang*. (2021) Identifification of pimavanserin tartrate as a potent Ca2+-calcineurin-NFAT pathway inhibitor for glioblastoma therapy. Acta Pharmacol Sin. 42(11):1860-1874.
Ø 4. Baichuan Li, Yang Xu, Yong Quan, Qiyan Cai, Yifan Le, Teng Ma, Zhi Liu, Guangyan Wu, Fei Wang, Chuncha Bao, and Hongli Li*. (2020) Inhibition of RhoA/ROCK Pathway in the Early Stage of Hypoxia Ameliorates Depression in Mice via Protecting Myelin Sheath. ACS Chem Neurosci 11(17): 2705-2716
Ø 5. Chuncha Bao, Zhong Yang, Qian Li,1 Qiyan Cai, Hongli Li* and Bin Shu*(2020) Aerobic Endurance Exercise Ameliorates Renal Vascular Sclerosis in Aged Mice by Regulating PI3K/AKT/mTOR Signaling Pathway. DNA AND CELL BIOLOGY 39(2): 1–11
Ø 6. Ruicheng Fan, Heng Wang, Liyuan Zhang, Teng Ma, Yanping Tian*and Hongli Li*. (2020) Nanocrystallized Oleanolic Acid Better Inhibits Proliferation, Migration and Invasion in Intracranial Glioma via Caspase-3 Pathway. journal of cancer 11(7): 1949-1958
Ø 7. Yi Yang , Jiaxiang Xiong , Jiangjun Wang , Yan Ruan , Junlei Zhang ,Yanping Tian , Jiali Wang , Lianlian Liu , Yuda Cheng , Xueyue Wang , Yixiao Xu ,Jiaqi Wang , Meng Yu , Bingyu Zhao , Yue Zhang , Hongli Li*, Rui Jian*. (2020) Novel alternative splicing variants of Klf4 display different capacities for self-renewal and pluripotency in mouse embryonic stem cells. Biochemical and Biophysical Research Communications 377-384
Ø 8. Chuncha Bao, Zhong Yang, Qiyan Cai, Qian Li, Hongli Li* and Bin Shu*. (2019) Incremental load training improves renal fibrosis by regulating the TGF‑β1/TAK1/MKK3/p38MAPK signaling pathway and inducing the activation of autophagy in aged mice. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE1677-1686
Ø 9. Teng Ma, Baichuan Li, Yifan Le, Yang Xu, Fei Wang, Yanping Tian, Qiyan Cai, Zhi Liu, Lan Xiao, Hongli Li*. (2019) Demyelination contributes to depression comorbidity in a rat model of chronic epilepsy via dysregulation of Olig2/LINGO-1 and disturbance of calcium homeostasis. Experimental Neurology 321: 113034
Ø 10. Zhenzhen Liu#, Hongli Li#, Lian He#, Yu Xiang, Chengsen Tian, Can Li, Peng Tan, Ji Jing, Yanpin Tian, Lupei Du, Yun Huang, Leng Han*, Minyong Li*, and Yubin Zhou*.(2019) Discovery of Small-Molecule Inhibitors of the HSP90-Calcineurin-NFAT Pathway against Glioblastoma. Cell Chemical Biology 26(3): 352-365
Ø 11. Ting Cao, Teng Ma, Yang Xu, Yanping Tian, Qiyan Cai, Baichuan Li, Hongli Li*. (2019) Caffeine Treatment Promotes Differentiation and Maturation of Hypoxic Oligodendrocytes via Counterbalancing Adenosine 1 Adenosine Receptor-Induced Calcium Overload. Med Sci Monit.25:1729-1739
Ø 12. Qiyan Cai, Teng Ma,Yanping Tian, ,Chengren Li and Hongli Li*. (2018) Catalpol Inhibits Ischemia-Induced Premyelinating Oligodendrocyte Damage through Regulation of Intercellular Calcium Homeostasis via Na⁺/Ca2+ Exchanger 3. Int. J. Mol. Sci.19(7):1925
Ø 13. Jintao Li, Ji Zhang, Hongxia Guo, Shimin Yang, Weiping Fan, Nan Ye1, Zhiqiang Tian, Tiantian Yu, Guoping Ai, Zigang Shen, Haiyang He, Ping Yan, Hui Lin, Xue Luo, Hongli Li* and Yuzhang Wu*. (2018) Critical Role of Alternative M2 Skewing in miR-155 Deletion-Mediated Protection of Colitis. Front Immunol 9:904.
Ø 14. Tao Li, Lingyun Wang, Teng Ma, Shouyu Wang, Jianqin Niu, Hongli Li*, Lan Xiao*. (2018) Dynamic Calcium Release from Endoplasmic Reticulum Mediated by Ryanodine Receptor 3 is Crucial for Oligodendroglial Differentiation. Frontiers in Molecular Neuroscience. Front Mol Neurosci 11:162
Ø 15. Fei Wang, Yu-Jian Yang, Nian Yang, Xian-Jun Chen, Nan-Xin Huang, Jun Zhang, Yi Wu, Zhi Liu, Xing Gao, Tao Li, Guang-Qiang Pan, Shu-Bao Liu, Hong-Li Li, Stephen P J Fancy, Lan Xiao*, Jonah R Chan*, Feng Mei*. (2018) Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia. Neuron 99(4): 689–701.e5.
Ø 16. Feixiang He, Yuchen Peng, Zhi Yang, Zilu Ge, Yanping Tian, Teng Ma, Hongli Li*. (2017) Activated ClC-2 Inhibits p-Akt to Repress Myelination in GDM Newborn Rats, Int. J. Biol. Sci 13(2): 179-188
Ø 17. Qiyan Cai, Teng Ma, Chengren Li, Yanping Tian, Hongli Li*. (2016) Catalpol Protects Pre-Myelinating Oligodendrocytes against Ischemia-induced Oxidative Injury through ERK1/2 Signaling Pathway, Int. J. Biol. Sci 12(12): 1415-1426
Ø 18. Hanzhi Wang, Shubao Liu, Yanping Tian, Xiyan Wu, Yangtao He, Chengren Li, Michael Namaka, Jiming Kong, Hongli Li*, Lan Xiao*. (2015) Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1-Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repair in a Cuprizone-Induced Mouse Model of Demyelination, Front Cell Neurosci 21(9): 492
Ø 19. Teng Ma, Xiyan Wu, Qiyan Cai, Yun Wang, Lan Xiao, Yanping Tian*, Hongli Li*. (2015) Lead Poisoning Disturbs Oligodendrocytes Differentiation Involved in Decreased Expression of NCX3 Inducing Intracellular Calcium Overload, Int. J. Mol. Sci 16(8):19096-110
Ø 20. Baixiong Zhao, Hongyu Quan, Teng Ma, Yanping Tian, Qiyan Cai, Hongli Li*. (2015) 4,4'-Diisothiocyanostilbene-2,2' -disulfonic Acid (DIDS) Ameliorates Ischemia-Hypoxia-Induced White Matter Damage in Neonatal Rats through Inhibition of the Voltage-Gated Chloride Channel ClC-2, Int. J. Mol. Sci 16(5): 10457-10469
Ø 21. Qiyan Cai, Zhongxiang Yao, Hongli Li*.(2014) Catalpol Promotes Oligodendrocyte Survival and Oligodendrocyte Progenitor Differentiation via the Akt Signaling Pathway in Rats with Chronic Cerebral Hypoperfusion, Brain research 29(1560): 27-35
Ø 22. Hongyu Quan, Xiyan Wu, Yanping Tian, Yun Wang, Chengren Li, Hongli Li*. (2014) Overexpression of CDK5 in neural stem cells facilitates maturation of embryonic neurocytes derived from rats in vitro, Cell Biochem Biophys 69(3):445-453
Ø 23. Hongyu Quan, Teng Ma, Xianxian Zhao, Baixiong Zhao, Yunlai Liu, Hongli Li*. (2014) Vinyl chloride monomer (VCM) induces high occurrence of neural tube defects in embryonic mouse brain during neurulation, Cellular and Molecular Neurobiology 34(4): 619-630
Ø 24. Hongyu Quan, Hao Tang, Li Fang, Jianjun Bi, Yunsheng Liu*, Hongli Li*. (2014) IGF1(CA)19 and IGFBP-3-202A/C Gene Polymorphism and Cancer Risk: A Meta-analysis, Cell Biochem Biophys 69: 169-178
Ø 25.José Miguel Eltit, Hongli Li, Christopher W. Wardb , Tadeusz Molinskic , Isaac N. Pessahd , Paul D. Allen and José R. Lopez. (2011) Orthograde dihydropyridine receptor signal regulates ryanodine receptor passive leak. Proc Natl Acad Sci U S A. 108(17): 7046-51.
Ø 26. Hongli Li, Xudong Ding, Jose R. Lopez, Hiroshi Takeshima, Jianjie Ma*, Paul D. Allen, Jose M. Eltit. (2010) Impaired Orai1-mediated resting Ca2+ entry reduces the cytosolic [Ca2+] and sarcoplasmic reticulum Ca2+ loading in quiescent junctophilin 1 knock-out myotubes, J Biol Chem 285(50): 39171-39179
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二、专利
获得国家发明专利授权1项。梓醇和维甲酸药物组合在制备预防或治疗脑白质损伤的药物中的应用 ZL 2013 1 0223326.6 2015.2
三、研究课题
先后主持国家自然基金面上项目、重庆市自然科学基金面上项目、重庆市人口与计划生育研究基金项目；以及军队专项、陆军军医大学科技创新能力提升专项前沿探索项目和陆军军医大学基础医学院转型预研项目等课题9项。
