弘深青年教师
学习经历
2018.9-2023.6浙江大学劳动卫生与环境卫生学博士
2013.9-2018.6杭州师范大学预防医学学士
工作经历
2023.6-至今重庆大学医学院
学术任职
重庆市神经科学学会副秘书长
研究方向
重金属代谢毒性特征及机制研究
成果：
一、代表性论文（#，第一；*，通讯）
1.Huihui Hong#, Jia Xu, Haotian He,Xue Wang, Lingling Yang, Ping Deng, Lu Yang, Miduo Tan, Jingjing Zhang, Yudong Xug, Tong Tong, Xiqin Lin, Huifeng Pi,* Yuanqiang Lu*, Zhou Zhou*. Cadmium perturbed metabolomic signature in pancreatic beta cells correlates with disturbed metabolite profile in human urine.Environment International.2022, 161: DOI: 10.1016/j.envint.2022.107139
2.Huihui Hong#, Yudong Xu, Jia Xu, Jingjing Zhang, Yu Xi, Huifeng Pi, Lingling Yang, Zhengping Yu, Qingqian Wu, Zhuoxian Meng, Shuzhen Xu, Yunzhao Ren, Wei-shuyi Ruan, Yuan-qiang Lu*, Zhou Zhou*. Cadmium exposure impairs pancreatic β-cell function and exaggerates diabetes by disrupting lipid metabolism.Environment International.2021, 149: DOI: 10.1016/j.envint.2021.1064061.
3.Huihui Hong#, Xiqin Lin, Yudong Xu, Tong Tong, Jingjing Zhang, Haotian He, Lingling Yang, Yuanqiang Lu*, Zhou Zhou*. Cadmium induces ferroptosis mediated inflammation by activating Gpx4/Ager/p65 axis in pancreatic β-cells.Science of the Total Environment.2022, 849: DOI: 10.1016/j.scitotenv.2022.157819
4.Xu Y#,Hong H#, Lin X, Tong T, Zhang J, He H, Yang L, Mao G, Hao R, Deng P, Yu Z, Pi H, Cheng Y, Zhou Z*. Chronic cadmium exposure induces Parkinson-like syndrome by eliciting sphingolipid disturbance and neuroinflammation in the midbrain of C57BL/6J mice.Environ Pollut.2023 Sep 22;337:122606. doi: 10.1016/j.envpol.2023.122606. Epub ahead of print. PMID: 37742865.
5.Lin X, Xu Y, Tong T, Zhang J, He H, Yang L, Deng P, Yu Z, Pi H,Hong H*, Zhou Z*. Cadmium exposure disturbs myocardial lipid signature and induces inflammation in C57BL/6J mice.Ecotoxicol Environ Saf.2023 Oct 15;265:115517. doi: 10.1016/j.ecoenv.2023.115517. Epub 2023 Sep 28. PMID: 37776818.
6.Huihui Hong#, Haotian He, Xiqin Lin, Tali Hayuehashi, Jia Xu, Jingjing Zhang, Yudong Xu, Tong Tong, Yuanqiang Lu*, Zhou Zhou*. Cadmium exposure suppresses insulin secretion through mtROS-mediated mitochondrial dysfunction and inflammatory response in pancreatic beta cells.Journal of Trace Elements in Medicine and Biology.2022, 71: DOI: 10.1016/j.jtemb.2022.126952
7.Tong, T, Duan, WX, Xu, YD ,Hong, HH, Xu, J, Fu, GY, Wang, X, Yang, LL, Deng, P, Zhang, JJ, He, HT, Mao, GF, Lu, YQ, Lin, XQ, Yu, ZP, Pi, HF, Cheng, Y*, Xu, S*C, Zhou Zhou*. Paraquat exposure induces Parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain.Environment International.2022, 169: DOI: 10.1016/j.envint.2022.107512
8.Deng P, Li J, Lu Y, Hao R, He M, Li M, Tan M, Gao P, Wang L,Hong H, Tao J, Lu M, Chen C, Ma Q, Yue Y, Wang H, Tian L, Xie J, Chen M, Luo Y, Yu Z, Zhou Z*, Pi H*. Chronic cadmium exposure triggered ferroptosis by perturbing the STEAP3-mediated glutathione redox balance linked to altered metabolomic signatures in humans.Sci Total Environ.2023 Sep 14;905:167039. doi: 10.1016/j.scitotenv.2023.167039. Epub ahead of print. PMID: 37716689.
9.Xi Y, Liu M, Xu S,Hong H,Chen M, Tian L, Xie J, Deng P, Zhou C, Zhang L, He M, Chen C, Lu Y, Reiter RJ, Yu Z, Pi H*, Zhou Z*. Inhibition of SERPINA3N-dependent neuroinflammation is essential for melatonin to ameliorate trimethyltin chloride-induced neurotoxicity.J Pineal Res.2019 Oct;67(3):e12596. doi: 10.1111/jpi.12596. Epub 2019 Aug 6. PMID: 31332839.
10.He H, Lin X, Tong T, Xu Y,Hong H, Zhang J, Xu Y, Huang C*, Zhou Z*. Cadmium exposure impairs skeletal muscle function by altering lipid signature and inducing inflammation in C57BL/6J mice.Ecotoxicol Environ Saf.2023 Jun 15;258:114986. doi: 10.1016/j.ecoenv.2023.114986. Epub 2023 May 8. PMID: 37163905.
二、科研项目
1.教育部重点实验室开放课题（2020DCKF001；主持；5万）
2.国家自然科学基金面上项目（82173468；参与；55万）
