易斌*

编辑:gys 发布时间:2020-06-12 12:18

现任陆军军医大学第一附属医院麻醉科副主任、教授、主任医师、博士研究生导师。陆军科技英才计划优先培养对象。重庆市学科带头人后备人选。陆军军医大学优秀研究生导师。


学习经历

1993年入学临床医学首批7年制,导师杨和平教授,获得硕士学位

2007年获得博士学位,导师为全军呼吸研究所钱桂生教授


工作经历

2000年进入西南医院麻醉科,住院医师

2002年获批主治医师、讲师。

2008年获批副教授、副主任医师资格。

2012年资格任命、科室副主任、硕士研究生导师。

2016年获批博士研究生导师。

2017年12月获批教授、主任医师资格。

目前担任中华医学会麻醉学分会全国青年委员、全军麻醉青年委员会副主任委员、中国心胸血管麻醉学会围术期基础与转化医学分会全国委员;中俄医科大学联盟疼痛学术委员会青年委员会常委、重庆市医学会和医师会委员等。


研究方向、教学课程

围术期肺保护


成果:1.文章2.专利3.项目4.获奖

【文章】以第一作者或通讯作者(含共同)发表SCI目录】总共33篇。

1. Chen L(#),Han,Y, Li YJ, Chen B, Bai XH, Belguise K, Wang XB, Chen Y(*),Yi B(*), Lu KZ(*). Hepatocyte-derived exosomal MiR-194 activates PMVECs and promotes angiogenesis in hepatopulmonary syndrome. Cell Death & Disease. 2019 (10): 853.doi:10.1038/s41419-019 -2087-y(SCI article, IF:5.959,2区) (当年IF:5.959,2区)(81870422)

2. Chen Y(#), Yang CW(#), Li YJ, Chen L, Yang Y, Belguise K, Wang XB, Lu KZ(*), Yi B(*).MiR145-5p inhibits proliferation of PMVECs via PAI-1 in experimental hepatopulmonary syndrome rat pulmonary microvascular hyperplasia. Biology Open (2019) 8, bio04800.(SCI article, IF:1.962,3区) (当年IF:1.962,3区)(81870422)

3. Yang YH(#), Yu HP(#), Yang CW, Zhang YF, Ai XF, Wang XB, Lu KZ(*),Yi B(*).Krü ppel-like factor 6 mediates pulmonary angiogenesis in rat experimental hepatopulmonary syndrome and is aggravated by bone morphogenetic protein 9.Biology Open (2019) 8, bio040121. doi:10.1242/bio.040121(SCI article, IF:1.962,3区) (当年IF:1.962,3区)(81870422)

4. Zhang XH(#),Li YJ(#), He WQ, Yang CW, Gu JT, Lu KZ,Yi B(*).Combined ultrasound and nerve stimulator-guided deep nerve block may decrease the rate of local anesthetics systemic toxicity: a randomized clinical trial. BMC Anesthesiology. 2019,19:103.DOI 10.1186/s12871-019-0750-6(SCI article, IF:1.619,4区)(81870422,81670552)(当年IF:1.619,4区),(ISSN:1471-2253

5. Gao J(#), Yu HP(#), Bai XH, Liu C, Chen L, Belguise K, Wang XB, Lu KZ(*), Hu ZY(*),Yi B(*). Loss of cell polarity regulated by PTEN/Cdc42 enrolled in theprocess of Hepatopulmonary Syndrome. Journal of cellular and molecular medicine. 2019, 00:1–11.https ://doi.org/10.1111 /jcmm.14437(SCI article, IF:4.658,2区)(81870422,81670552),(当年IF:4.658,2区),(ISSN:1582-4934

6. Tang X(#), Liu C(#), Chen L, Yang ZY, Belguise K, Wang XB, Lu KZ, Yan H(*), Yi B(*). Cyclooxygenase-2 regulates HPS patient serum induced-directional collective HPMVEC migration via PKC/Rac signaling pathway. Gene, 2019, 692:176-184(SCI article, IF:2.638,3区)(81870422,81670552)(当年IF:2.638,3区;ISSN:0378-1119

7. Chen B(#), Yang Z, Yang CW,Gu JT, Hu C, Chen A, Ning JN(*), Yi B(*), Lu KZ(*).A self-organized actomyosin drives multiple intercellular junction disruption and directly promotes neutrophil recruitment in lipopolysaccharide-induced acute lung injury. FASEB journal(Journal Official Publication of the Federation of American Societies for Experimental Biology), 2018:fj201701506RR.doi: 10.1096/fj.201701506RR(SCI article, IF:5.391,2区)(当年IF:5.391,2区;ISSN:0892-6638)

8. Cheng FJ(#), Yang ZY(#), Zeng J, Gu JT, Ning JN,Yi B(*).Anesthesia Management of ModifiedEx VivoLiver Resection and Autotransplantation. Annals of Transplantation. 2018,23:274-284.DOI: 10.12659/AOT.907796.( SCI article, IF:1.369,4区)(当年IF:1.369,4区;ISSN:1425-9524

9. Qin X(#), Hannezo E, Mangeat T, Liu C, Majumder P, Liu J, Cadamuro V, McDonald J, Liu YY(*),Yi B(*), Wang XB(*).A biochemical network controlling basal myosin oscillation. Nature communications, 2018 Mar 23;9(1):1210. doi: 10.1038/s41467-018-03574-5.(SCI article, IF:11.878,1区)(81670552)(当年IF:12.411区;ISSN:2041-1723

10. Yang CW(#), Lv KY, Chen B, Yang Y, Ai XF, Yu HF, Yang YH,Yi B(*), Lu KZ(*). miR144-3p inhibits PMVECs excessive proliferation in angiogenesis of hepatopulmonary syndrome via Tie2. Experimental Cell Research. 2018;365(1):24-32. doi: 10.1016/j.yexcr.2018.02.009. Epub 2018 Feb 15.( SCI article, IF:3.329,2区)(81670552)(当年IF:3.46,2区;ISSN:0014-4827

11. Shen CC(#), Chen B, Gu JT, Ning JL,Zeng J, Yi B(*), Lu KZ(*). AMD3100 treatment attenuates pulmonary angiogenesis by reducing the c-kit (+) cells and its pro-angiogenic activity in CBDL rat lungs. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2018;1864(3): 676-684.doi: 10.1016/j.bbadis.2017.12.011(SCI article,IF:4.328,2区)(81670552)(当年IF,5.64,2区;ISSN:0925-4439

12. Wei SW, Luo CX, Yu SP, Gao J, Liu C, Wei Z, Zhang Z, Wei L(*),Yi B(*). Erythropoietin ameliorates early brain injury after subarachnoid haemorrhage by modulating microglia polarization via the EPOR/JAK2-STAT3 pathway. Experimental Cell Research. 2017,361(2):342-352. doi: 10.1016/j.yexcr.2017.11.002( SCI article, IF:3.329,2区)(当年IF:3.546,2区;ISSN:0014-4827

13. Liu C(#), Gao J, Chen B, Chen L,Belguise K,Yu WF, Lu K,Wang XB(*),Yi B(*).Cyclooxygenase-2 promotes pulmonary intravascular macrophage accumulation by exacerbating BMP signaling in rat experimental hepatopulmonary syndrome. Biochemical Pharmacology, 2017, 138: 205-215( SCI article,IF:4.825,2区)(当年IF:4.581,2区;ISSN:0006-2952

14. Chen Q(#),Yi B(#),Ma JB, Ning JL, Wu LZ, Ma DQ, Lu KZ(*), Gu JT(*). α2-adrenoreceptor modulated FAK pathway induced by dexmedetomidine attenuates pulmonary microvascular hyper-permeability following kidney injury. Oncotarget, 2016,7(35):55990~56001(剔除SCI),(当年IF:5.008,2区;ISSN:1949-2553

15. Xu D(#), Chen B, Gu JT, Chen L, Belguise K, Wang XB,Yi B(*), Lu KZ(*).Inhibition of autophagy ameliorates pulmonary microvascular dilation and PMVECs excessive proliferation in rat experimental hepatopulmonary syndrome. Scientific reports. 2016, 6:30833. DOI:10.1038/srep30833( SCI article, IF:4.011,3区)(当年IF:5.228,3区;ISSN:2045-2322

16. Shen CC(#), Chen B, Gu JT, Ning JL, Chen L, Zeng J,Yi B(*), Lu KZ(*). The angiogenic related functions of bone marrow mesenchymal stem cells are promoted by CBDL rat serum via the Akt/Nrf2 pathway. Experimental Cell Research. 2016, 344(1):86-94( SCI article, IF:3.329,2区)(当年IF:3.378,2区;ISSN:0014-4827

17. Yang ZY(#),Yi B(*).Patient experience of sexual hallucinations after propofol‑induced painless abortion may lead to violence against medical personnel. Journal of Anesthesia. 2016, 30:486-488( SCI article, IF:1.462,4区)(当年IF:1.343,4区;ISSN:0913-8668

18. Chen Y(#), Wen XR(#), Wang Z, Zeng J, Chen B, Yang Y, Lu KZ, Gu JT(*),Yi B(*).Annexin A2 inhibits the migration of PASMCs stimulated with HPS rat serum by down-regulating the expression of paxillin.Biochemical and Biophysical Research Communications. 2016,469: 70-75( SCI article, IF:2.705,3区)(当年IF:2.371,3区;ISSN:0006-291X

19. Zeng J(#), Chen L(#), Chen B, Lu KZ, Belguise K, Wang XB(*),Yi B(*). MicroRNA-199a-5p Regulates the Proliferation of Pulmonary Microvascular Endothelial Cells in Hepatopulmonary Syndrome. Cellular Physiology and Biochemistry. 2015, 37, 1289-1300当年IF:4.652,2区;ISSN:1015-8987

20. Gao J(#), Chen L(#),Zeng J, Cui J, Ning JL, Wang GS, Belguise K, Wang XB, Qian GS, Lu KZ,Yi B(*). The involvement of aquaporin 1 in the hepatopulmonary syndrome rat serum-induced migration of pulmonary arterial smooth muscle cells via the p38-MAPK pathway.Molecular BioSystems, 2015;11:3041-47.( SCI article, IF:2.855,3区)当年IF:1.752,3区,ISSN:1073-6085

21. Liu C(#), Chen L(#), Zeng J, Cui J, Ning JN, Wang GS, Belguise K, Wang X, Qian GS, Lu KZ,Yi B(*). Bone morphogenic protein-2 regulates the myogenic differentiation of PMVECs in CBDL rat serum-induced pulmonary microvascular remodeling. Experimental Cell Research. 2015,336 (10):109-118.( SCI article, IF:3.329,2区)当年IF:3.378,2区;ISSN:0014-4827

22. Yang Y(#),Chen B,Chen Y,Zu B,Yi B(*),Lu K(*). A comparison of two common bile duct ligation methods to establish hepatopulmonary syndrome animal models.Laboratory animals.2015,49(1):71-79.( SCI article, IF:1.26,4区)当年IF:1.553,4区;ISSN:0023-6772

23. Chen B(#), Ning Jl, Gu JT, Cui J, Yang Y, Wang z,Zeng J,Yi B(*),Lu K(*). Caspase-3 inhibition prevents the development of hepatopulmonary syndrome in CBDL-rats by alleviating pulmonary injury. Liver international,2015;35:1373-1382. ( SCI article, IF:5.542,2区);当年IF:4.47,2区;ISSN:1478-3223

24. Chen Y(#),Yi B(#), Wang Z, Lu K. Paxillin suppresses the proliferation of HPS rat serum treated PASMCs by up-regulating the expression of cytoskeletal proteins. Molecular BioSystems. 2014.10(4):759-66( SCI article, IF:2.855,3区)当年IF:3.21;3区;ISSN:1742-206X

25. Chen L(#), Li YS, Cui J, Ning JL, Wang GX, Qian GS, Lu KZ,Yi B(*).MiR-206 Controls the Phenotypic Modulation of Pulmonary Arterial Smooth Muscle Cells Induced by Serum from Rats with Hepatopulmonary Syndrome by Regulating the Target Gene, Annexin A2.Cellular Physiology and Biochemistry.2014;34:1768-1779(剔除SCI)当年IF:2.875;3区;ISSN:1015-8987

26. Yi B(#), Zeng J, Wang G, Qian G, Lu K.Annexin A1 protein regulated the expression of PMVEC cytoskeletal proteins in CBDL ratserum-induced pulmonary microvascular remodeling. Journal of translational medicine. 2013, 11(1):98( SCI article, IF:4.098,2区)当年IF:3.991,2区;ISSN: 1479-5876

27. Zeng J(#),Yi B(#), Wang Z, Ning J, Wang X, Lu K. Effect of Annexin A2 on hepatopulmonary syndrome rat serum-induced proliferation of pulmonary arterial smooth muscle cells. Respiratory physiology & neurobiology. 2013, 185(2):332-338( SCI article, IF:1.582,4区);当年IF:1.967,4区;ISSN:1569-9048

28. Yi B(#),Cui J, Ning J, Gu J,Wang G, Bai L,Qian G,Lu K.cGMP-dependent protein kinase I(transfecion inhibits hypoxia-induced migration, phenotype modulation and Annexins A1 expression in human pulmonary artery smooth muscle cells.Biochemical and Biophysical Research Communications. 2012,418(4): 598-602( SCI article, IF:2.705,3区)当年IF2.406,3区;ISSN:0006-291X

29. Yi B(#), Cui J, Ning J, Wang G, Qian G,Lu K. Over-expression of PKGIα inhibits hypoxia-induced proliferation, Akt activation, and phenotype modulation of human PASMCs: the role of phenotype modulation of PASMCs in pulmonary vascular remodeling. Gene. 2012,25;492(2):354-360.( SCI article, IF:2.638,3区)2.196,3区;0378-1119

30. Luo CX(#), Yi B(*), Bai L,Xia YZ, Wang GS, Qian GS, Feng H. Suppression of Akt1 phosphorylation by adenoviral transfer of the PTEN gene inhibits hypoxia-induced proliferation of rat pulmonary arterial smooth muscle cells. Biochem Biophys Res Commun. 397(3):486-92. 2010(SCI, article, IF 2.705,3区)当年IF2.595,3区;0006-291X

31. Luo CX(#), Yi B(#), Chen Z, Tang WH, Chen YJ, Hu R, Liu Z, Feng H*, Zhang JH. PKGIα inhibits the proliferation of cerebral arterial smooth muscle cell induced by oxyhemoglobin after subarachnoid hemorrhage.Acta Neurochir Suppl.110(3): 167-171.2011(SCI, article, IF 1.834,4区)当年IF 1.19,4区;ISSN0001-6268

32. Luo C(#),Yi B(#,Tao G,Li M,Chen Z,Tang W,Zhang JH,Feng H*. Adenosine A3 receptor agonist reduces early brain injury in subarachnoid haemorrhage.Neuroreport. 21(13):892-896.2010(SCI, article, IF 1.146,4区),当年 IF1.822,4区;0959-4965

33. Luo C(#), Yi B(#,Tao G,Fan W,Chen K,Gui L,Chen Z,Li L,Feng H*,Chi L. Enhanced angiogenesis and astrocyte activation by ecdysterone treatment in a focal cerebral ischemia rat model. Acta Neurochir Suppl. 110(3): 151-155.2010(SCI, article, IF 1.834,4区)当年IF1.19,4区;ISSN0001-6268

【主持的课题目录】

1. 2019年军委十三五计划项目麻醉军医训练模拟平台建设100万。

2. 2019年重庆市技术创新与应用研究发展专项:cstc2019jscx-msxmX0237基于人工智能算法的术后心血管危重不良事件早期预警研究;(20万,2019.9.1-2021.8.31)

3. 2018年全国医学专业学位研究生教育指导委员会课题:B2-YX20180302-10,基于人工智能的麻醉学专业硕士临床技能培训考核系统的建立和应用研究;(2018.5-2020.4)

4. 国家重点研发计划课题:2018YFC0116702,重症和手术监护临床大数据集支持系统;(400万,2018.8-2021.8)

5. 国家自然科学基金面上项目:81870422;病肝来源BMP9活化ALK1-Endoglin调控病理性血管增生在肝肺综合征重症化中的作用和机制研究;(直接费用:60万;2019.1-2022.12)

6. 国家自然科学基金面上项目:81670552;PTEN/ANXA2-Cdc42调控肺微血管内皮细胞极性丢失在肝肺综合征IPVD中的作用和机制研究;(直接费用:58万;2017.1-2020.12)

7. 国家自然基金面上项目:81170053;AnnexinsA1/A2的膜聚集对肺血管重建中PASMCs表型转换的调控作用和机制研究;(直接费用:50万;2012.1-2015.12)

8. 国家自然科学基金项目青年基金:30700347;蛋白激酶GIa途径调节PASMC表型在低氧肺血管重建中的作用与机制研究;(直接费用:17万;2008.1-2010.12)

9. 中国学位与研究生教育学会教学课题:B-2017Y0503-060;基于改良Mini-CEX的麻醉学专业型硕士研究生临床技能培训SOP设计和应用研究;2017.11.10— 2019.11.08。(直接费用:1.5万)

10. 重庆市基础科学与前沿技术研究cstc2016jcyjA0120;Cdc42调控肺微血管内皮细胞极性丢失在肺血管重建中的作用和机制研究。

11. 中国学位与研究生教育学会教学课题::C-2015Y0403-033;临床教学大数据在提高麻醉专业硕士研究生个体化临床培训质量的探索和应用;2015年08月07日至2017年03月31日

12. 重庆市自然科学基金,蛋白激酶GIa途径调节PASMC表型在低氧肺血管重建中的作用与机制研究,项目编号:CSTC,2007BB5045,2万元,密码串27210174,88771849

13. 军事临床医学教学改革计划;基于Mini-CEX的住培生麻醉学临床技能培训SOP设计和应用研究;2017,SWH2016JG032,6万

14. 军事医学百项临床新技术计划项目;基于CEE的肝肺综合症患者筛选新技术在军队医院的应用;2017,SWH2016JSTSZD-02,20万