陆军军医大学全军临床病理学研究所副主任医师、副教授，国家级青年人才
学习经历
2010/09-2016/06第三军医大学全军病理学研究所病理学与病理生理学专业 医学博士
2014/04-2016/03美国Cleveland Clinic医学中心Lerner Research Institute干细胞与再生医学系 联合培养博士
2005/09-2010/06第三军医大学病理诊断专业 医学学士
工作经历
2019/10-今，陆军军医大学全军病理学研究所，副教授/副主任医师
2018/10-2019/10，陆军军医大学全军病理学研究所，副教授/主治医师
2016/10-2018/10，陆军军医大学全军病理学研究所，博士后
研究方向、教学课程
时雨，陆军军医大学全军临床病理学研究所副教授、副主任医师、博士生导师，国家自然科学基金优秀青年基金和重庆自然科学基金杰出青年基金获得者，国家重点研发计划首席青年科学家，获中华医学会“中国病理研究杰出青年奖”和重庆市“十佳科技青年奖”。兼任中国抗癌协会青年理事、中国抗癌协会肿瘤转移专业委员会常务委员，中华医学会病理学分会科研工作委员会副组长。
研究方向：主要从事“脑胶质瘤血管免疫微环境调控机制及其诊疗意义”研究，系统研究胶质瘤干细胞（glioma stem cell, GSC）干性表型调控机制，阐明了GSC与肿瘤相关巨噬细胞（TAM）互作特征和调控网络，绘制TAM空间分布图谱，解析TAM表型异质性和调控肿瘤血管正常化新功能，发展了靶向TAM免疫治疗新策略。主持国家重点研发计划青年科学家项目、国家自然科学基金优秀青年基金在内的国家及省部级课题9项。发表论文50余篇，其中以第一或通讯作者发表SCI论文19篇（IF>20论文5篇，IF>10论文6篇），他引3800余次，H-index=31。担任SCI杂志Modern Pathology、Laboratory Investigation、Genes & Diseases编委。授权国家发明专利8件。获中国医师协会脑胶质瘤专业委员会优秀青年科技工作者、中国抗癌协会肿瘤转移研究青年英才奖，曾入选国家博士后创新人才支持计划。
教学课程：作为重庆市高校一流本科课程（病理学）团队骨干，承担本科和研究生病理学和肿瘤学的理论、实训和前沿进展课程授课达1000余课时，深受学生欢迎，评为陆军军医大学“教学标兵”。坚持基础与临床相结合，启发学生科研创新能力，指导学生获得“全国大学生基础医学实验设计比赛特等奖”和“全国高等医药院校第二届大学生形态学绘图大赛二等奖”。加强肿瘤病理学建设和发展，作为导师/导师组成员培养硕士研究生9名和博士研究生8名，被评为“重庆市青年专家工作室领衔专家”。
成果：
一、以通讯(＊)/第一作者(含共同#)发表的代表性SCI收录论文19篇
(1) Wenying Wang#, Tianran Li#, Yue Cheng#, Fei Li#, Shuhong Qi#, Min Mao, Jingjing Wu, Qing Liu, Xiaoning Zhang, Xuegang Li, Lu Zhang, Haoyue Qi, Lan Yang, Kaidi Yang, Zhicheng He, Shuaishuai Ding, Zhongyi Qin, Ying Yang, Xi Yang, Chunhua Luo, Ying Guo, Chao Wang, Xindong Liu, Lei Zhou, Yuqi Liu, Weikai Kong, Jingya Miao, Shuanghui Ye, Min Luo, Lele An, Lujing Wang, Linrong Che, Qin Niu, Qinghua Ma, Xia Zhang, Zhihong Zhang, Rong Hu, Hua Feng, Yi-Fang Ping*, Xiu-Wu Bian*,Yu Shi*. Identification of Hypoxic Macrophages in Glioblastoma with Therapeutic Potential for Vasculature Normalization.Cancer Cell2024, S1535-6108(24)00119-3. doi: 10.1016/j.ccell.2024.03.013 (IF=50.3).
(2) Xiao-Ning Zhang, Kai-Di Yang, Cong Chen, Zhi-Cheng He, Qiang-Hu Wang, Hua Feng, Sheng-Qing Lv, Yan Wang, Min Mao, Qing Liu, Yao-Yao Tan, Wen-Ying Wang, Tian-Ran Li, Lin-Rong Che, Zhong-Yi Qin, Ling-Xiang Wu, Min Luo, Chun-Hua Luo, Yu-Qi Liu, Wen Yin, Chao Wang, Hai-Tao Guo, Qing-Rui Li, Bin Wang, Wei Chen, Shuang Wang,Yu Shi*, Xiu-Wu Bian*, Yi-Fang Ping*. Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling.Cell Research2021, 31:1072-1087 (IF=46.3).
(3) Jian Zhong#, Xujia Wu#, Yixin Gao#,Junju Chen#, Maolei Zhang, Huangkai Zhou, Jia Yang, Feizhe Xiao, Xuesong Yang, Nunu Huang, Haoyue Qi, Xiuxing Wang*, Fan Bai*,Yu Shi*, Nu Zhang*. Circular RNA encoded MET variant promotes glioblastoma tumorigenesis.Nature Communications2023, 14(1):4467 (IF=16.6).
(4)Jian Zhong#, Xuesong Yang#, Junju Chen#, Kejun He#, Xinya Gao, Xujia Wu, Maolei Zhang, Huangkai Zhou, Feizhe Xiao, Lele An, Xiuxing Wang*,Yu Shi*, Nu Zhang*. Circular EZH2-encoded EZH2-92aa mediates immune evasion in glioblastoma via inhibition of surface NKG2D ligands.Nature Communications2022, 13(1):4795(IF=16.6).
(5)Yu Shi, Olga A. Guryanova, Wenchao Zhou, Chong Liu, Zhi Huang, Xiaoguang Fang, Xiuxing Wang, Cong Chen, Qiulian Wu, Zhicheng He, Wei Wang, Wei Zhang, Tao Jiang, Qing Liu, Yaping Chen, Wenying Wang, Jingjing Wu, Leo Kim, Ryan C. Gimple, Hua Feng, Hsiang-Fu Kung, Jennifer S. Yu, Jeremy N. Rich, Yifang Ping*, Xiu-Wu Bian*, Shideng Bao*. Ibrutinib Inactivates BMX-STAT3 in Glioma Stem Cells to Impair Malignant Growth and Radioresistance.Science Translational Medicine2018, 10(443): eaah6816 (IF=17.9).
(6)Wen Yin, Yi-Fang Ping, Fei Li, Sheng-Qing Lv, Xiao-Ning Zhang, Xue-Gang Li, Ying Guo, Qing Liu, Tian-Ran Li, Liu-Qing Yang, Kai-Di Yang, Yu-Qi Liu, Chun-Hua Luo, Tao Luo, Wen-Ying Wang, Min Mao, Min Luo, Zhi-Cheng He, Mian-Fu Cao, Cong Chen, Jing-Ya Miao, Hui Zeng, Chao Wang, Lei Zhou, Ying Yang, Xi Yang, Qiang-Hu Wang, Hua Feng,Yu Shi*, Xiu-Wu Bian*. A map of the spatial distribution and tumour-associated macrophage states in glioblastoma and grade-4 IDH-mutant astrocytoma.Journal of Pathology2022, 258(2):121-135(IF=7.3).
(7) Xiao-Hong Yao#, Tao Luo#,Yu Shi#, Zhi-Cheng He#, Rui Tang#, Pei-Pei Zhang#, Jun Cai, Xiang-Dong Zhou, Dong-Po Jiang, Xiao-Chun Fei, Xue-Quan Huang, Lei Zhao, Heng Zhang, Hai-Bo Wu, Yong Ren, Zhen-Hua Liu, Hua-Rong Zhang, Cong Chen, Wen-Juan Fu, Heng Li, Xin-Yi Xia, Rong Chen, Yan Wang, Xin-Dong Liu, Chang-Lin Yin, Ze-Xuan Yan, Juan Wang, Rui Jing, Tai-Sheng Li, Wei-Qin Li, Chao-Fu Wang, Yan-Qing Ding, Qing Mao, Ding-Yu Zhang, Shu-Yang Zhang*, Yi-Fang Ping*, Xiu-Wu Bian*. A cohort autopsy study defines COVID-19 systemic pathogenesis.Cell Research2021, 31(8):836-846 (IF=46.3).
(8) Qian Liu#,Yu Shi#, Jun Cai#, Yaqi Duan#, Rongshuai Wang#, Hongyan Zhang#, Qiurong Ruan#, Jiansha Li#, Lei Zhao#, Yifang Ping#, Rong Chen#, Liang Ren#, Xiaochun Fei, Heng Zhang, Rui Tang, Xi Wang, Tao Luo, Xindong Liu, Xuequan Huang, Zhenhua Liu, Qilin Ao, Yong Ren, Jing Xiong, Zhicheng He, Haibo Wu, Wenjuan Fu, Pengnan Zhao, Xinwei Chen, Guoqiang Qu, Yunyun Wang, Xi Wang, Jia Liu, Dongfang Xiang, Sanpeng Xu, Xiaowei Zhou, Qingrui Li, Jinghong Ma, Heng Li, Jie Zhang, Sizhe Huang, Xiaohong Yao*, Yiwu Zhou*, Chaofu Wang*, Dingyu Zhang*, Guoping Wang*, Liang Liu*, Xiu-Wu Bian*. Pathological Changes in the Lungs and Lymphatic Organs of 12 COVID-19 Autopsy Cases.National Science Review2020, 7(12): 1868-1878 (IF=17.3).
(9)Yu Shi, Yi-Fang Ping, Wenchao Zhou, Zhi-Cheng He, Cong Chen, Bai-Shi-Jiao Bian, Lin Zhang, Lu Chen, Xun Lan, Xian-Chao Zhang, Kai Zhou, Qing Liu, Hua Long, Ti-Wei Fu, Xiao-Ning Zhang, Mian-Fu Cao, Zhi Huang, Xiaoguang Fang, Xiuxing Wang, Hua Feng, Xiao-Hong Yao, Shi-Cang Yu, You-Hong Cui, Xia Zhang, Jeremy N. Rich, Shideng Bao*, Xiu-Wu Bian*. Tumour-associated Macrophages Secrete Pleiotrophin to Promote PTPRZ1 Signalling in Glioblastoma Stem Cells for Tumour Growth.Nature Communications2017, 8:15080 (IF=14.9).
(110)Yu Shi, Yifang Ping, Xia Zhang, Xiuwu Bian*. Hostile takeover: glioma stem cells recruit TAMs to support tumor progression.Cell Stem Cell2015, 16(3):219-220 (IF=22.4).
(11) Si Wang#, Xiaohong Yao#, Shuai Ma#, Yifang Ping#, Yanling Fan#, Shuhui Sun#, Zhicheng He#,Yu Shi#, Liang Sun#, Shiqi Xiao#, Moshi Song#, Jun Cai, Jiaming Li, Rui Tang, Liyun Zhao, Chaofu Wang, Qiaoran Wang, Lei Zhao, Huifang Hu, Xindong Liu, Guoqiang Sun, Lu Chen, Guoqing Pan, Huaiyong Chen, Qingrui Li, Peipei Zhang, Yuanyuan Xu, Huyi Feng, Guo-Guang Zhao, Tianzi Wen, Yungui Yang, Xuequan Huang, Wei Li, Zhenhua Liu, Hongmei Wang, Haibo Wu, Baoyang Hu, Yong Ren, Qi Zhou*, Jing Qu*, Weiqi Zhang*, Guang-Hui Liu*, Xiu-Wu Bian*. A single-cell transcriptomic landscape of the lungs of patients with COVID-19.Nature Cell Biology2021, 23(12): 1314-1328 (IF=28.8).
(12) Zhi-Cheng He, Qing Liu, Kai-Di Yang, Cong Chen, Xiao-Ning Zhang, Wen-Ying Wang, Hui Zeng, Bin Wang, Yu-Qi Liu, Min Luo, Lei Li, Qin Niu, Hui-Min Lu, Tao Luo, Xiao-Hong Yao, Hai-Tao Guo, Jia-Le Ji, Mian-Fu Cao,Yu Shi*, Yi-Fang Ping*, Xiu-Wu Bian*. HOXA5 is amplified in glioblastoma stem cells and promotes tumor progression by transcriptionally activating PTPRZ1.Cancer Letters2022, 533, 215605. (IF=9.7).
(13)Yu Shi, Wenchao Zhou, Lin Cheng, Cong Chen, Zhi Huang, Xiaoguang Fang, Qiulian Wu, Zhicheng He, Senlin Xu, Justin Lathia, Yifang Ping, Jeremy Rich, Xiu-Wu Bian*, Shideng Bao*. Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells.Cell Death & Differentiation2017, 24(1): 167-180 (IF=15.8).
(14)Yu Shi#, Cong Chen#, Shizhu Yu, Qing Liu, Jun Rao, Huarong Zhang, Hualiang Xiao, Tiwei Fu, Hua Long, Zhicheng He, Kai Zhou, Xiahong Yao, Youhong Cui, Xia Zhang, Yifang Ping*, Xiu-Wu Bian*. miR-663 suppresses oncogenic function of CXCR4 in glioblastoma.Clinical Cancer Research2015, 21(17): 4004-4013 (IF=8.7).
(15)Yu Shi, Cong Chen, Xia Zhang, Qing Liu, Jinling Xu, Huarong Zhang, Xiaohong Yao, Tao Jiang, Zhicheng He, Yong Ren, Wei Cui, Chuan Xu, Ling Liu, Youhong Cui, Shizhu Yu, Yifang Ping*, Xiu-Wu Bian*. Primate specific miR-663 functions as a tumor suppressor by targeting PIK3CD and predicts the prognosis of human glioblastoma.Clinical Cancer Research2014, 20(7):1803-1813 (IF=8.7).
(16) Zhe Wang#, Bin Wang#,Yu Shi#, Chuan Xu, Hualiang Xiao, Leina Ma, Senlin Xu, Lang Yang, Qingliang Wang, Weiqi Dang, Wei Cui, Shicang Yu, Yifang Ping, Youhong Cui, Hsiangfu Kung, Cheng Qian, Xia Zhang*, Xiu-Wu Bian*. Oncogenic miR-20a and miR-106a enhance the invasiveness of human glioma stem cells.Oncogene2015, 34(11):1407-19 (IF=9.8).
(17) Min Luo#, Yu-Qi Liu#, Hua Zhang, Chun-Hua Luo, Qing Liu, Wen-Ying Wang, Zhi-Cheng He, Cong Chen, Xiao-Ning Zhang, Min Mao, Kai-Di Yang, Chao Wang, Xiao-Qing Chen, Wen-Juan Fu, Qin Niu, Xiu-Wu Bian,Yu Shi*, Yi-Fang Ping*. Overexpression of carnitine palmitoyltransferase 1A promotes mitochondrial fusion and differentiation of glioblastoma stem cells. Laboratory Investigation 2022, 102(7):722-730（IF=5.6）.
(18) Kai Zhou, Jun Rao, Zhihua Zhou, Xiaohong Yao, Feng Wu, Jing Yang, Lang Yang, Xia Zhang, Youhong Cui, Xiu-Wu Bian*,Yu Shi*, Yifang Ping*. RAC1-GTP promotes epithelial-mesenchymal transition and invasion of colorectal cancer by activation of STAT3.Laboratory Investigation2018, 98(8):989-998 (IF=3.7).
(19) Kai Zhou, Yue-Liang Yao, Zhi-Cheng He, Cong Chen, Xiao-Ning Zhang, Kai-Di Yang, Yu-Qi Liu, Qing Liu, Wen-Juan Fu, Ya-Ping Chen, Qin Niu, Qing-Hua Ma, Rong Zhou, Xiao-Hong Yao, Xia Zhang, You-Hong Cui, Xiu-Wu Bian*,Yu Shi*, Yi-Fang Ping*. VDAC2 interacts with PFKP to regulate glucose metabolism and phenotypic reprogramming of glioma stem cells.Cell Death & Disease2018, 9(10):988. (IF=8.5).
二、专利
(1)时雨;平轶芳;刘庆;杨莹;安乐乐;齐皓月;一种PTN-PTPRZ1通路的阻断抗体及其在胶质瘤靶向治疗的应用,授权公告日2024-03-26,中国, ZL20231 1015361.9.
(2)时雨;卞修武;杨莹;刘庆;周磊;安乐乐;王路静;抗人PTPRZ1单克隆抗体及其在细胞流式中的应用,授权公告日2024-03-15,中国, ZL202310088884.X.
(3)时雨;平轶芳;卞修武;何志承;陈聪;廖嘉明;靶向干扰肿瘤PTN-PTPRZ1通路的小干扰RNA在肿瘤免疫治疗中的应用, 2019-03-08,中国, ZL201610980647.4.
(4)时雨;王文英；吴晶晶；平轶芳；卞修武; ADM竞争性拮抗剂AMA在胶质瘤免疫治疗中的应用, 2021-05-14,中国, ZL201910250793.5.
(5)张晓宁;易维京;时雨;平轶芳;卞修武;蔡瑞丽;廖嘉明; CD146单克隆抗体在胶质瘤血管周细胞检测及分离鉴定中的应用, 2019-03-15,中国, ZL201611078356.2.
(6)张晓宁;时雨;平轶芳;谭瑶瑶;谭玉环;徐媛媛;卞修武;靶向OTUD7B基因的小干扰RNA在胶质瘤靶向治疗中的应用, 2020-09-29,中国, ZL201910287712.9.
(7)刘庆;时雨;平轶芳;刘宇奇;颜泽萱;卞修武;脑胶质瘤巨噬细胞类配体的体系构建，授权公告日2023-10-27,中国, ZL202111187331.7.
(8)杨凯迪；卞修武；平轶芳；时雨；孔维凯；徐媛媛；钮芹；一种基于核密度函数的量化胶质瘤侵袭性的可视化方法，2020-10-26，中国，ZL 202011157737.6
(9)罗春花；平轶芳；时雨；卞修武；一种压力和气体可调节的细胞培养装置，授权公告日2022-12-27，中国，CN 218146698 U
三、目前承担的代表性科研项目4项
(1)国家重点研发计划干细胞专项青年科学家项目，2021YFA1103000，诱导性多能干细胞（iPSC）源性嵌合抗原受体巨噬细胞（CAR-M）的制备及其在恶性肿瘤免疫治疗中的应用，500万元，2021/12-2026/06，主持。
(2)重庆市自然科学基金杰出青年基金项目，2023NSCQ-JQX0049，胶质瘤血管免疫微环境的细胞互作机制及诊疗意义，100万元，2023/07-2026/06，在研，主持。
(3)国家自然科学基金面上项目，82373191，胶质母细胞瘤新靶向药依鲁替尼抑制肿瘤相关巨噬细胞吞噬的作用机制研究，48万元，2024/01-2027/12，在研，主持。
(4)重庆市人力资源与社会保障局重庆市专家工作室项目，425Z2W32，时雨专家工作室专家资助费，10万元，2022/07-2025/06，在研，主持。
四、代表性奖励和荣誉8项
（1）2022年入选“重庆市青年专家工作室”领衔专家
（2）2021年荣获“重庆市十佳科技青年奖”
（3）2019年被评为“中国医师协会脑胶质瘤专业委员会优秀青年科技工作者”
（4）2017年荣获“中国病理研究杰出青年奖”
（5）2017年荣获“中国抗癌协会肿瘤转移研究青年英才奖”
（6）2017年博士论文被评为“重庆市优秀博士毕业论文”
（7）2017年博士论文被评为“全军优秀博士毕业论文”
（8）2016年入选国家首批“博士后创新人才支持计划”
