张燕燕

编辑:王昌林 发布时间:2024-08-29 11:32

研究员/PI,硕士生导师

学习经历

(1) 2008-09至2014-07,中国科学院-上海生命科学研究院,生物学,博士

(2) 2003-09至2007-07,西南大学-生物技术学院,生物技术,学士

科研与学术工作经历

(1) 2021-09至今,中国科学院大学重庆学院,巴渝学者双聘PI

(2) 2021-07至今,重庆大学附属人民医院(重庆医学科学院),研究员/PI

(3) 2017-07至2021-06,陆军军医大学,国家免疫学重点实验室,副研究员/博士后

(4)2014-09至2017-03,美国MDAnderson Cancer Centre,研究学者/博士后

研究方向、教学课程

1.基础研究方面

1)感染免疫机制研究;

2)肿瘤免疫机制研究。

2.转化研究方面

1)感染免疫中的疫苗研发、免疫治疗与免疫诊断;

2)肿瘤免疫中的疫苗研发、免疫治疗与免疫诊断。

成果:1.文章2.项目3.获奖4.学术影响

(一)相关代表性论著情况

1.Yanyan Zhang*#; Baohua Li*; Qiang Bai*; Pengcheng Wang; Gang Wei; Zhirong Li; Li Hu; Qin Tian; Jing Zhou; Qizhao Huang; Zhiming Wang; Shuai Yue; Jialin Wu; Liuqing Yang; Xinyuan Zhou; Lubin Jiang; Ting Ni; Lilin Ye#; Yuzhang Wu# (2021).The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8establishmentvia regulating the dual effects of IL-7 signaling.Signal Transduction and Targeted Therapy126(6).(5Y-IF37.2,Lead Author & Lead Contact, Citation 22, JCR-Q1)

2.Zhen Xing*;YanyanZhang*; Ke Liang*; Liang Yan; Yu Xiang; Chunlai Li; Qingsong Hu; Leng Han; Feng Jin; Vasanta Putluri; Nagireddy Putluri; Cristian Coarfa; Arun Sreekumar; Peter K. Park; Tina K. Nguyen; Shouyu Wang; Jianwei Zhou; Yan Zhou; Jeffrey R. Marks; David H. Hawke; Mien-Chie Hung; Liuqing Yang; Leng Han; Haoqiang Ying; Chunru Lin(2018).Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer.Cancer Research78(16): 4524-4532.(5Y-IF13.0,First Author of equal-contribution, Citation51, JCR-Q1)

3.Yanyan Zhang; Feifei Mao; Yi Lu; Wenqing Wu; Lei Zhang#; Yun Zhao#(2011).Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus.Cell Research21(10): 1436-1451.(5Y-IF 39.3,Independent First Author, Featured Article, Citation41, JCR-Q1)

4.Yanyan Zhang*; Qiang Bai*; Ting Ni; Liuqing Yang; Lubin Jiang; Lilin Ye#; Yuzhang Wu# (2020).The LncRNA Snhg1 is Essential for Memory CD8 T Cell Establishment.Journal of Immunology204(1).(5Y-IF5.2,Lead Author, AAI-2020, JCR-Q2)

5.Qiang Zhou*; Dan Chen*; Junfeng Zhang; Jifeng Xiang; Tao Zhang; Huaizhi Wang#;YanyanZhang#;Pancreatic ductal adenocarcinoma holds unique features to form an immunosuppressive microenvironment.Journal of Pancreatology, 2022,5(4): 174-185. (Lead Contact, ESCI, CSTPC)

6.Baohua Li*; Qiang Bai*; Pengcheng Wang; Zhirong Li; Li Hu; Xinyuan Zhou; Yuzhang Wu#; Lilin Ye#;Yanyan Zhang#;(2019).The long-non-coding RNA Snhg1 is essencial for memory CD8 T cell establishment.European Journal of Immunology49(SI):242.(5Y-IF5.5,Lead Contact, IUIS-2019, JCR-Q2)

7.Qingsong Hu*; Chunlai Li*; Shouyu Wang*; Yajuan Li*; Bo Wen;Yanyan Zhang; Ke Liang; Jun Yao; Youqiong Ye; Heidi Hsiao; Tina K. Nguyen; Peter K. Park; Sergey D. Egranov; David H. Hawke; Jeffrey R. Marks; Leng Han; Mien-Chie Hung; Bing Zhang; Chunru Lin#; LiuqingYang#(2019).LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition.Cell Research29(4): 286-304.(5Y-IF39.3,ThirdAuthor,Citation 35, JCR-Q1)

8.Aifu Lin*; Chunlai Li*; Zhen Xing*; Qingsong Hu; Ke Liang; Leng Han; Cheng Wang; David H Hawke; Shouyu Wang;YanyanZhang; Yongkun Wei; Guolin Ma; Peter K. Park; Jianwei Zhou; Yan Zhou; Zhibin Hu; Yubin Zhou; Jeffery R. Marks; Han Liang; Mien-Chie Hung; Chunru Lin#; Liuqing Yang#(2016).The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer.Nature Cell Biology18(2): 213-224.(5Y-IF26.6, Co-author, Highly cited paper,Citation 390, JCR-Q1)

9.Lifan Xu*, Qizhao Huang*, Haoqiang Wang*, Yaxing Hao*, Qiang Bai, Jianjun Hu,Yiding Li,Pengcheng Wang,Xiangyu Chen, Ran He, Bingshou Li, Xia Yang, Tingting Zhao,Yanyan Zhang, Yifei Wang, Juanjuan Ou,Houjie Liang, Yuzhang Wu, Xinyuan Zhou, and Lilin Ye(2017).The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells.Immunity47(3).(5Y-IF 36.3, Co-author, Citation 85, JCR-Q1)

10.Minglu Xiao*; Luoyingzi Xie*; Guoshuai Cao*; Shun Lei*; Pengcheng Wang; Zhengping Wei; Yuan Luo; Jingyi Fang; Xingxing Yang; Qizhao Huang; Lifan Xu; Junyi Guo; Shuqiong Wen; Zhiming Wang; Qing Wu; Jianfang Tang; Lisha Wang; Xiangyu Chen; Cheng Chen;Yanyan Zhang;Wei Yao; Jianqiang Ye#; Ran He#; Jun Huang#; Lilin Ye#;CD4+ T-cell epitope-based heterologous prime-boost vaccinationpotentiates anti-tumor immunity and PD-1/PD-L1 immunotherapy.Journal forImmunoTherapy of Cancer, 2022, 1(5): e004022.(5Y-IF 12.6, Co-author, Citation 7, JCR-Q1)

(二)主持科研项目及人才计划项目情况

(1)中共重庆市科学技术局, “重庆英才计划”青年拔尖人才项目, CQYC2021059730,长链非编码RNA在病毒感染及肿瘤免疫中调控T细胞免疫应答与免疫记忆的研究, 2022-01至2024-12, 80万元,在研,主持

(2)国家自然科学基金委员会,青年科学基金项目, 31800763,长链非编码RNA Malat1拮抗记忆CD8 T细胞分化形成的机制研究, 2019-01-01至2021-12-31, 26万元,结题,主持

(3)中共重庆市人力资源和社会保障局,重庆留学人才回国创新支持计划, CX2022081,病毒感染免疫中lncRNA Neat2调控CD8 T细胞免疫应答的效应与记忆研究, 2022-09至2024-08, 5万元,在研,主持

(4)中国博士后科学基金委员会,特别资助项目, 2020T130791,病毒感染免疫中调控记忆性CD8 T细胞建立的lncRNAs研究, 2020-09至2021-08, 36(18+18)万元,结题,主持

(5)中共重庆市人力资源和社会保障局,重庆博士后人才留渝资助项目, 2111012718365225, LncRNAs和T细胞相关的肿瘤免疫学研究, 2022-09至2025-08, 15万元,在研,主持

(三)学术奖励情况

(1)重庆英才奖励计划-青年拔尖人才奖,中共重庆市委组织部,自然科学, 2021

(2)巴渝学者奖励计划-青年学者奖,中共重庆市教育委员会,自然科学,2021

(3)地奥一等奖,中国科学院,自然科学, 2013

(4)辉瑞特等奖,中国科学院,自然科学, 2011

(四)论著之外的学术兼职与学术影响

1.国际国内学术兼职情况

(1)2021年至今,美国Journal of Cancer Immunology学术编委

(2)2021年至今,欧洲European Journal of Clinical and Biomedical Sciences学术编委

(3)2021年至今,德国Wiley旗下期刊(AdvancedSciencesIF17.521)等)邀约审稿人

(4)2021年至今,英国Nature Publishing Group旗下期刊(Signal Transduction and Targeted TherapyIF38.120)等)邀约审稿人;

(5)2021年至今,瑞士Frontiers系列期刊(Frontiers in Immunology, Frontiers in Oncology等)邀约审稿人

(6)2021年至今,中国免疫学会高级会员

(7)2021年至今,中国细胞生物学会会员

(8)2021年至今,中国生物化学与分子生物学会会员

2.国际国内学术报告情况

(1)全国核糖核酸(RNA)青年学术会议,兰州, 2023-04-20至2023-04-23(会议报告)

(2)中国细胞生物学学术大会,苏州, 2023-04-10至2023-04-14 (会议报告)

(3)中国免疫学学术大会,成都, 2021-10-21至2021-10-24 (会议报告)

(4)中科院青年生命科学论坛,北京, 2021-06-04至2021-06-06 (会议报告)

(5)冷泉港亚洲免疫会议,国际线上会议, 2021-04-20至2021-04-22 (会议报告)

(6)国际免疫学学术大会,北京, 2019-10-19至2019-10-23 (会议报告)