学习经历
2000-2007 陕西师范大学 本硕
2008-2011 南开大学 博士
2011-2016 美国威斯康星大学麦迪逊分校 博士后
工作经历
2017.1-至今 西安交通大学第二附属医院 教授
2024.7-至今 重庆大学附属涪陵医院 教授
学术任职
中国生理学会血液生理专业委员会委员
中国病理生理学会实验血液学专业委员会委员
中国医药质量管理协会细胞治疗质量控制与研究专业委员会委员
中国医药生物技术协会科研实验室建设与管理分会常委
研究方向、教学课程
血液肿瘤发病机制及靶向治疗、肿瘤分子生物学
成果：
科研项目
82370146 在幼年型粒单核细胞白血病中鉴定CD69作为其白血病干细胞新表面标记的实验研究 国家自然科学基金面上项目 主持
82170140 基于造血干祖细胞异质性研究幼年型粒单核细胞白血病对MEK抑制剂耐药的新机制 国家自然科学基金面上项目 主持
81922003 骨髓异常增生/骨髓增殖性肿瘤 国家自然科学基金优秀青年科学基金项目主持
2019YFA0801804 跨器官通讯影响病理状态下造血稳态的作用和机理 国家重点研发计划课题 课题负责人
81770127 Runx1在慢性粒单核细胞白血病中的作用及其机制研究 国家自然科学基金面上项目 主持
81600100 Notch信号通路在幼年型粒单核细胞白血病中细胞自主性和非细胞自主性作用的研究 国家自然科学基金青年项目 主持
发表文章
1. Yin M, Liu L, Yan Y, Wang H, Li W, Dong Y, Kong G#. A targeting nanoplatform for chemo-photothermal synergistic therapy of small-cell lung cancer. Int J Cancer. 2024 Jul 10.
2. Liu J, Li L, He S, Zheng X, Zhu D, Kong G#, Li P#. EXPLORING THE PROGNOSTIC NECROPTOSIS-RELATED GENES AND UNDERLYING MECHANISM IN SEPSIS USING BIOINFORMATICS. Shock. 2024 Sep 1;62(3):363-374
3. Zhong F, He S, Guo N, Shi L, Zhang L, Jin H, Kong G#. A novel immunogenic cell death-related classification indicates the immune landscape and predicts clinical outcome and treatment response in acute myeloid leukemia. Cancer Cell Int. 2024 Apr 16;24(1):139.
4. Jia Y, Liu R, Shi L, Feng Y, Zhang L, Guo N, He A, Kong G#. Integrative analysis of the prognostic value and immune microenvironment of mitophagy-related signature for multiple myeloma. BMC Cancer. 2023 Sep 12;23(1):859.
5. Jia Y, Yu X, Liu R, Shi L, Jin H, Yang D, Zhang X, Shen Y, Feng Y, Zhang P, Yang Y, Zhang L, Zhang P, Li Z#, He A#, Kong G#. PRMT1 methylation of WTAP promotes multiple myeloma tumorigenesis by activating oxidative phosphorylation via m6A modification of NDUFS6. Cell Death &Disease, 2023 Aug 9;14(8):512.
6. Li Z, He Z, Wang J, Kong G#. RNA splicing factors in normal hematopoiesis and hematologic malignancies: novel therapeutic targets and strategies. J Leukoc Biol, 2023 Feb 1;113(2):149-163.
7. Zhongqiang Zheng, Huan Wang, Liang Li, Shaoying Zhang, Chunyan Zhang, Hailong Zhang, Fanpu Ji, Xi Liu, Kai Zhu, Guangyao Kong#, Zongfang Li#. Splenectomy enhances the Ly6Clow phenotype in hepatic macrophages by activating the ERK1/2 pathway during liver fibrosis. Int Immunopharmacol. 2020
8. Li J, Li R, Jiang W, Sun J, Li J, Guo Y, Zhu K, Zhang C, Kong G#, Li Z#. Splenic serum from portal hypertensive patients enhances liver stem cell proliferation and self-renewal via the IGF-II/ERK signaling pathway. Dig Liver Dis. 2020
9. Zhang H, Zhang S, Zhang J, Zhou R, Nie Y, Ren S, Li J, Feng K, Ji F, Kong G#, Li Z#. Improvement of human platelet aggregation post-splenectomy with paraesophagogastric devascularization in chronic hepatitis B patients with cirrhotic hypersplenism. Platelets. 2019
10. Zhu K, Li J, Li J, Sun J, Guo Y, Tian H, Li L, Zhang C, Shi M, Kong G#, Li Z#. Ring1 promotes the transformation of hepatic progenitor cells into cancer stem cells through the Wnt/β-catenin signaling pathway. J Cell Biochem. 2019
11. Sun J, Guo Y, Bie B, Zhu M, Tian H, Tian J, Li J, Yang Y, Ji F, Kong G#, Li Z#. Silencing of long noncoding RNA HOXD-AS1 inhibits proliferation, cell cycle progression, migration and invasion of hepatocellular carcinoma cells through MEK/ERK pathway. J Cell Biochem. 2019
12. You X, Wen Z, Chang YI, Ranheim EA, Zhou Y, Zhou L, Kong G#, Zhang J#. Systemic Notch downregulation promotes KrasG12D -induced myeloproliferative neoplasm. Br J Haematol. 2019
13. Kong G*#, You X*, Wen Z, Chang YI, Qian S, Ranheim EA, Letson C, Zhang X, Zhou Y, Liu Y, Rajagopalan A, Zhang J, Stieglitz E, Loh M, Hofmann I, Yang D, Zhong X, Padron E, Zhou L, Pear WS, Zhang J.#. Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. Leukemia. 2019
14. Lu Z*, Hong CC*, Kong G*, Assumpção ALFV#, Ong IM, Bresnick EH, Zhang J, Pan X. Polycomb Group Protein YY1 Is an Essential Regulator of Hematopoietic Stem Cell Quiescence. Cell Rep. 22(6):1545-1559. 2018
15. Li Y, Jiang W, Li ZZ, Zhang C, Huang C, Yang J, Kong GY#, Li ZF#. Repetitive restraint stress changes spleen immune cell subsets through glucocorticoid receptor or β-adrenergic receptor in a stage dependent manner. Biochem Biophys Res Commun. 2018
16. Wang P, Li Z, Ren S, Li J, Yang J, Kong G#, Jiang A#, Li Z#.Spleen Regulates Hematopoietic Stem/Progenitor Cell Functions Through Regulation of EGF in Cirrhotic Hypersplenism.Dig Dis Sci.2018
17. Jiang W, Li Y, Sun J, Li L, Li JW, Zhang C, Huang C, Yang J, Kong GY#, Li ZF#. Spleen contributes to restraint stress induced changes in blood leukocytes distribution. Sci Rep. 2017
18. Zhang J*, Kong G*, Rajagopalan A, Lu L, Song J, Hussaini M, Zhang X, Ranheim EA, Liu Y, Wang J, Gao X, Chang YI, Johnson KD, Zhou Y, Yang D, Bhatnagar B, Lucas DM, Bresnick EH, Zhong X, Padron E, Zhang J. p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia. Blood. 2017
19. Kong G, Chang YI, You X, Ranheim EA, Zhou Y, Burd CE, Zhang J. The ability of endogenous Nras oncogenes to initiate leukemia is codon-dependent. Leukemia. 2016
20. Kong G*, Chang Y-I*, Damnernsawad A*, You X*, Du J, Ranheim E, Lee W, Ryu M, Zhou Y, Xing Y, Chang Q, Burd C, Zhang J. Loss of wild-type Kras promotes activation of all Ras isoforms in oncogenic Kras-induced leukemogenesis. Leukemia. 2016
21. Johnson, K. D.*, Kong, G*, Gao, X., Chang, Y-I., Hewitt, K. J., Sanalkumar, R., Sanalkumar, P., Ranheim, R. A., Dewey, C. N., Zhang, J., and Bresnick, E. H. Cis-regulatory Mechanisms Governing Stem and Progenitor Cell Transitions. Science Advances. Science Advances 2015
22. Kong G, Wunderlich M, Yang D, Ranheim EA, Young KH, Wang J, Chang YI, Du J, Liu Y, Tey SR, Zhang X, Juckett M, Mattison R, Damnernsawad A, Zhang J, Mulloy JC, Zhang J. Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm. The Journal of Clinical Investigation. 2014
23. Wang J*, Kong G*, Liu Y, Du J, Chang YI, Tey SR, Zhang X, Ranheim EA, Saba-El-Leil MK, Meloche S, Damnernsawad A, Zhang J, Zhang J. NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions. Blood. 2013
24. Kong G*, Du J*, Liu Y, Meline B, Chang YI, Ranheim EA, Wang J, Zhang J. Notch1 mutations target Kras G12D CD8+ cells and contribute to their leukemogenic transformation. J Biol Chem. 2013
25. Zhang W*, Kong G*, Zhang J, Wang T, Ye L, Zhang X. MiR-520b inhibits growth of hepatoma cells by targeting cyclin D1 and MEKK2. PLoS ONE, 2012
26. Kong G, Zhang J, Zhang S, Shan C, Ye L, Zhang X. Upregulated MicroRNA-29a by Hepatitis B Virus X Protein Enhances Hepatoma Cell Migration by Targeting PTEN in Cell Culture Model. PLoS ONE. 2011
27. Kong G, Zhang J, Zhang S, Shan C, Ye L, Zhang X. Hepatitis B Virus x protein promotes proliferation of hepatoma cells via upregulation of MEKK2. Acta Pharmacologica Sinica, 2011.
